scholarly journals Occupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case-control study

1998 ◽  
Vol 77 (11) ◽  
pp. 2048-2052 ◽  
Author(s):  
M Nordström ◽  
L Hardell ◽  
A Magnuson ◽  
H Hagberg ◽  
A Rask-Andersen
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Case Control ◽  
Hairy Cell Leukaemia ◽  
Cell Leukaemia ◽  
Hairy Cell ◽  
Animal Exposure ◽  
Control Study

scholarly journals O6E.6 Occupational exposures and ALS: international collaborations and new ways to identify risk factors

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A61.1-A61
Author(s):  
Susan Peters ◽  
Leonard van den Berg ◽  
Jan Veldink ◽  
Roel Vermeulen
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Disease Onset ◽  
Occupational Exposures ◽  
Case Control ◽  
Incidence Density ◽  
Recall Bias ◽  
Case Control Studies ◽  
Incident Cases ◽  
Control Study

BackgroundAssociations between occupational exposures and amyotrophic lateral sclerosis (ALS) have been suggested, but results are inconsistent. Case-control studies are best suited for inclusion of clinically confirmed incident cases, but prone to recall bias. Cohort studies are free from recall bias and may have pre-symptomatic blood stored, to inform about exposures (e.g. lead) well before disease onset.MethodsAn ongoing nation-wide ALS case-control study has been conducted in the Netherlands since 2006 (currently over 3000 cases and 4500 controls) to study risk factors and possible gene-environment interactions. Part of this study has been pooled with case-control studies from Ireland and Italy (Euro-MOTOR), where the same questionnaire was administered.ResultsWithin the Euro-MOTOR study, ∼1300 cases and ∼2600 controls had full job histories available. Occupational exposures to a range of agents were assessed using job-exposure matrices. Analyses were adjusted for age, sex, centre, education, smoking and alcohol. We found significant associations between ALS and exposure to silica (OR 1.73, 95% CI 1.28–2.33), extremely low-frequency magnetic fields (OR 1.16, 95% CI 1.01–1.33) and electric shocks (OR 1.23, 95% CI 1.05–1.43), independent of the other occupational exposures studied.Future perspectivesA nested ALS case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. 219 people who died from ALS have been identified, and pre-symptomatic blood samples from 168 of these cases are available for analyses. Three controls per case were selected by incidence density sampling matched by age at recruitment, sex and study centre. Metal concentrations will be analysed in the erythrocytes. This would be the first prospective study on the association between exposure to metals and ALS.ConclusionEach study design has its strengths and weaknesses, and ALS should be investigated in a range of (occupational) studies to gain better understanding of its aetiology.

Risk factors for esophageal adenocarcinoma: A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
B AVIDAN ◽  
A SONNENBERG ◽  
T SCHNELL ◽  
G CHEJFEC ◽  
A METZ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

RISK FACTORS FOR THE DEVELOPMENT OF HOLOPROSENCEPHALY: A MANITOBA-BASED CASE-CONTROL STUDY

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
S Vaz ◽  
B Chodirker ◽  
J Seabrook ◽  
C Prasad ◽  
A Chudley ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
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