scholarly journals Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma

1997 ◽  
Vol 76 (9) ◽  
pp. 1215-1220 ◽  
Author(s):  
R Colomer ◽  
J Aparicio ◽  
S Montero ◽  
C Guzmán ◽  
L Larrodera ◽  
...  
Keyword(s):  
Growth Factor ◽  
Breast Carcinoma ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Poor Prognosis ◽  
Human Breast Carcinoma ◽  
Fibroblast Growth ◽  
Human Breast ◽  
Low Levels

scholarly journals Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells.

1991 ◽  
Vol 2 (9) ◽  
pp. 699-708 ◽  
Author(s):  
N Quarto ◽  
D Talarico ◽  
R Florkiewicz ◽  
D B Rifkin
Keyword(s):  
Molecular Weight ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Molecular Weight ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
3T3 Cells ◽  
Low Levels ◽  
Nih 3T3 ◽  
Nih 3T3 Cells

The phenotypes of NIH 3T3 cells transfected with basic fibroblast growth factor (bFGF) cDNAs that express only the high molecular weight (HMW) forms of bFGF, the 18-kDa form, or all forms were examined. Cells producing the 18 kDa or all forms of bFGF were transformed at high levels of growth factor expression but were nontransformed at low levels. Cell producing low levels of HMW forms of bFGF were growth impaired when compared with the parental cells. These cells tended to form multinucleated giant cells, did not grow in soft agar, were nontumorigenic, had a normal bFGF receptor number, and had a nontransformed morphology. Cells expressing high levels of HMW bFGFs had a transformed morphology and were tumorigenic. These data suggest a specific functional role for HMWbFGF.

The role of basic fibroblast growth factor (bFGF) and it's receptor in human breast cancer

The Breast ◽  
1992 ◽  
Vol 1 (3) ◽  
pp. 152-153
Author(s):  
NJ Bundred ◽  
M Wellington ◽  
RA Walker ◽  
PR Baker ◽  
A Logan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Human Breast Cancer ◽  
Fibroblast Growth ◽  
Human Breast
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