scholarly journals The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia-reperfusion

1997 ◽  
Vol 75 (3) ◽  
pp. 319-323 ◽  
Author(s):  
CS Parkins ◽  
MRL Stratford ◽  
MF Dennis ◽  
M Stubbs ◽  
DJ Chaplin
Keyword(s):  
Murine Tumour ◽  
Tumour Model ◽  
Ischaemia Reperfusion ◽  
Extracellular Lactate ◽  
The Relationship

Magnetic sentinel lymph node biopsy in a murine tumour model

2016 ◽  
Vol 12 (4) ◽  
pp. 1045-1052
Author(s):  
Muneer Ahmed ◽  
Taeseong Woo ◽  
Kaichi Ohashi ◽  
Toshiki Suzuki ◽  
Akiko Kaneko ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Biopsy ◽  
Murine Tumour ◽  
Tumour Model ◽  
Node Biopsy

Quantitative and comparative study of haematoporphyrin-derived photosensitizers on a murine tumour model

1990 ◽  
Vol 5 (3) ◽  
pp. 309-316 ◽  
Author(s):  
Eberhard Unsöld ◽  
Christian Ell ◽  
Dieter Jocham ◽  
Ronald Sroka ◽  
Susanne Stocker
Keyword(s):  
Comparative Study ◽  
Murine Tumour ◽  
Tumour Model

Cdk8 deletion in the ApcMin murine tumour model represses EZH2 activity and accelerates tumourigenesis

2015 ◽  
Vol 237 (4) ◽  
pp. 508-519 ◽  
Author(s):  
Mark L McCleland ◽  
Tim M Soukup ◽  
Scot D Liu ◽  
Jonathan H Esensten ◽  
Felipe de Sousa e Melo ◽  
...  
Keyword(s):  
Murine Tumour ◽  
Tumour Model

scholarly journals Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin

Gut ◽  
1997 ◽  
Vol 41 (6) ◽  
pp. 763-770 ◽  
Author(s):  
A Anthony ◽  
R E Pounder ◽  
A P Dhillon ◽  
A J Wakefield
Keyword(s):  
Reperfusion Injury ◽  
Vascular Anatomy ◽  
Mucosal Injury ◽  
Rat Jejunum ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemic Injury ◽  
Ischaemia Reperfusion ◽  
Vasa Recta ◽  
Dose Study ◽  
The Relationship

Background—Indomethacin induces ulceration in the rat jejunum with sparing of the ileum. The ulcers localise between vasa recta along the mesenteric margin of the bowel, observations that have not been fully explained.Aim—To examine the relationship between the localisation of experimental ulcers and the vascular anatomy of the rat small intestine.Methods—The normal vascular anatomy of the rat jejunum and ileum was studied and compared using arterial carbon ink perfusion. The anatomical localisation of early and advanced lesions induced by indomethacin was examined with particular reference to the vasculature. Mucosal injury induced by feeding vessel ligation for 24 hours or brief ischaemia-reperfusion injury was examined. The existence of anatomically sensitive sites to indomethacin was tested in a two dose study.Results—In the rat jejunum, poorly vascularised sites along the mesenteric margin were highly susceptible to indomethacin induced injury, such sites being absent from the ileum. Villous contraction was a feature of both early indomethacin injury and ischaemia-reperfusion injury in the rat jejunum. Twenty four hour ligation of jejunal vasa brevia selectively induced ischaemic injury along the mesenteric margin. Two doses of indomethacin to rats did not induce greater injury than a single dose.Conclusions—Results support the hypothesis that the rat jejunum possesses vascularly compromised sites along the mesenteric margin that are susceptible to indomethacin induced injury. Indomethacin may cause ischaemia-reperfusion injury selectively at these sites.

In vivo absorption spectrum of disulphonated aluminium phthalocyanine in a murine tumour model

1996 ◽  
Vol 34 (2-3) ◽  
pp. 229-235 ◽  
Author(s):  
Rinaldo Cubeddu ◽  
Gianfranco Canti ◽  
Mario Musolino ◽  
Antonio Pifferi ◽  
Paola Taroni ◽  
...  
Keyword(s):  
Absorption Spectrum ◽  
Murine Tumour ◽  
Tumour Model ◽  
In Vivo Absorption ◽  
Aluminium Phthalocyanine

A method for long duration anaesthesia for a new hindlimb ischaemia-reperfusion model in mice

1997 ◽  
Vol 31 (2) ◽  
pp. 151-156 ◽  
Author(s):  
A. M. Wiersema ◽  
R. Dirksen ◽  
W. J. G. Oyen ◽  
J. A. van der Vliet
Keyword(s):  
Gamma Camera ◽  
Radioactive Tracer ◽  
Multiple Organ ◽  
Ischaemia Reperfusion ◽  
Long Duration ◽  
Ischaemia And Reperfusion ◽  
Inhalational Anaesthesia ◽  
The Relationship ◽  
Good Exposure

To study the relationship between ischaemia-reperfusion and multiple organ dysfunction syndrome (MODS), a new anaesthesia method was required to be applied to C57BL/6 mice. These mice are also used in a well accepted, standardized model for MODS using intraperitoneally administered zymosan (zymosan induced general inflammation, ZIGI). The aim was to develop a new model for ischaemia-reperfusion with 6 h of anaesthesia. This and further specific requirements for the combination of ischaemia-reperfusion and the ZIGI method, made us select inhalational anaesthesia using isoflurane in oxygen. This study evaluates whether long-term anaesthesia confounds the results of ischaemia-reperfusion and the ZIGI model. In addition the benefits of using the analgesic buprenorphine were evaluated. Ischaemia was induced with a tourniquet around the hindlimb. Ischaemia and reperfusion were verified by imaging a radioactive tracer with a gamma-camera. It was established that anaesthesia with isoflurane in oxygen caused little perturbation of body temperature and respiratory rate. A survival rate of 89% without noteworthy influence on organs was obtained. Buprenorphine proved to provide adequate analgesia and had no influence on measured parameters. In our experimental setting, this model with long duration anaesthesia allowed us to induce ischaemia and reperfusion of the hindlimb without perturbation of measurements. It also allowed good exposure of the abdomen and facilitated combination with the ZIGI model.

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