scholarly journals Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes

1997 ◽  
Vol 75 (9) ◽  
pp. 1256-1262 ◽  
Author(s):  
Y Hatta ◽  
S Takeuchi ◽  
J Yokota ◽  
HP Koeffler
Keyword(s):  
Ovarian Cancer ◽  
Loss Of Heterozygosity ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes

Infrequent loss of heterozygosity of the major tumour suppressor genes in Indian oral cancers

2002 ◽  
Vol 31 (4) ◽  
pp. 414-418 ◽  
Author(s):  
S. Kannan ◽  
H. Yokozaki ◽  
K. Jayasree ◽  
P. Sebastian ◽  
A. Mathews ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes ◽  
Oral Cancers

scholarly journals Tumour suppressor genes in ovarian cancer.

BMJ ◽  
1993 ◽  
Vol 307 (6910) ◽  
pp. 1009-1009 ◽  
Author(s):  
W Foulkes
Keyword(s):  
Ovarian Cancer ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes

scholarly journals Tumour suppressor genes and risk of metastasis in ovarian cancer.

BMJ ◽  
1993 ◽  
Vol 307 (6903) ◽  
pp. 542-542 ◽  
Author(s):  
W S Lowry ◽  
R J Atkinson
Keyword(s):  
Ovarian Cancer ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes

scholarly journals Tumour suppressor genes in sporadic epithelial ovarian cancer

Reproduction ◽  
2002 ◽  
pp. 341-353 ◽  
Author(s):  
Y Liu ◽  
TS Ganesan
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Positional Cloning ◽  
Tumour Progression ◽  
Tumour Suppressor ◽  
Western World ◽  
Tumour Suppressor Genes ◽  
Genetic Studies ◽  
Suppressor Genes ◽  
The Past

Ovarian cancer is the most frequent cause of death from gynaecological malignancies in the western world, and sporadic epithelial ovarian cancer is its most predominant form. The aetiology of sporadic ovarian cancer remains unknown. Genetic studies have enabled a better understanding of the evolution of tumour progression. A major focus of research has been to identify tumour suppressor genes implicated in sporadic ovarian cancer over the past decade. Several tumour suppressor genes have been identified by strategies such as positional cloning and differential expression display. Further research is warranted to understand fully their contribution to the pathogenesis of sporadic ovarian cancer.

Loss of heterozygosity (LOH) in tumour suppressor genes in benign and malignant mixed odontogenic tumours

2011 ◽  
Vol 41 (5) ◽  
pp. 389-393 ◽  
Author(s):  
Clarice F. Galvão ◽  
Carolina C. Gomes ◽  
Marina G. Diniz ◽  
Pablo A. Vargas ◽  
Alfredo M. B. de Paula ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes ◽  
Odontogenic Tumours

scholarly journals Aberrant Methylation Status of Tumour Suppressor Genes in Ovarian Cancer Tissue and Paired Plasma Samples

2019 ◽  
Vol 20 (17) ◽  
pp. 4119 ◽  
Author(s):  
Dana Dvorská ◽  
Dušan Braný ◽  
Bálint Nagy ◽  
Marián Grendár ◽  
Robert Poka ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Aberrant Methylation ◽  
Potential Candidate ◽  
Plasma Samples ◽  
Cdh1 Gene ◽  
Suppressor Genes ◽  
Non Invasive ◽  
Malignant Lesions

Ovarian cancer is a highly heterogeneous disease and its formation is affected by many epidemiological factors. It has typical lack of early signs and symptoms, and almost 70% of ovarian cancers are diagnosed in advanced stages. Robust, early and non-invasive ovarian cancer diagnosis will certainly be beneficial. Herein we analysed the regulatory sequence methylation profiles of the RASSF1, PTEN, CDH1 and PAX1 tumour suppressor genes by pyrosequencing in healthy, benign and malignant ovarian tissues, and corresponding plasma samples. We recorded statistically significant higher methylation levels (p < 0.05) in the CDH1 and PAX1 genes in malignant tissues than in controls (39.06 ± 18.78 versus 24.22 ± 6.93; 13.55 ± 10.65 versus 5.73 ± 2.19). Higher values in the CDH1 gene were also found in plasma samples (22.25 ± 14.13 versus 46.42 ± 20.91). A similar methylation pattern with positive correlation between plasma and benign lesions was noted in the CDH1 gene (r = 0.886, p = 0.019) and malignant lesions in the PAX1 gene (r = 0.771, p < 0.001). The random forest algorithm combining methylation indices of all four genes and age determined 0.932 AUC (area under the receiver operating characteristic (ROC) curve) prediction power in the model classifying malignant lesions and controls. Our study results indicate the effects of methylation changes in ovarian cancer development and suggest that the CDH1 gene is a potential candidate for non-invasive diagnosis of ovarian cancer.

Sign in / Sign up

Export Citation Format

Share Document