scholarly journals Up-regulation of urokinase-type plasminogen activator in squamous cell carcinoma of human larynx

1996 ◽  
Vol 74 (8) ◽  
pp. 1168-1174 ◽  
Author(s):  
S Parolini ◽  
D Flagiello ◽  
A Cinquetti ◽  
R Gozzi ◽  
S Cristini ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Plasminogen Activator ◽  
Squamous Cell ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Human Larynx

scholarly journals Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue

2018 ◽  
Vol 32 (0) ◽  
Author(s):  
Marianna Sampaio SERPA ◽  
Rodrigo Porpino MAFRA ◽  
Salomão Israel Monteiro Lourenço QUEIROZ ◽  
Leorik Pereira da SILVA ◽  
Lélia Batista de SOUZA ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Plasminogen Activator ◽  
Squamous Cell ◽  
Oral Tongue ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator

Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity

2007 ◽  
Vol 407 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Zonggao Shi ◽  
M. Sharon Stack
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Plasminogen Activator ◽  
Clinical Data ◽  
Squamous Cell ◽  
Serine Proteinase ◽  
Molecular Classification ◽  
Prognostic Indicator ◽  
Type Plasminogen Activator

OSCC (oral squamous cell carcinoma) is the most common oral malignancy and is estimated to affect approx. 350000 new patients worldwide this year. OSCC is characterized by a high degree of morbidity and mortality, as most patients exhibit local, regional and distant metastasis at the time of diagnosis. Recent genome-wide screening efforts have identified the serine proteinase uPA (urinary-type plasminogen activator, also known as urokinase) as a strong biomarker for prediction of poor disease outcome and a key candidate for molecular classification of oral neoplasms using a ‘gene signature’ approach. The proteinase uPA binds a surface-anchored receptor designated uPAR (uPA receptor), focalizing proteolytic activity to the pericellular milieu. Furthermore, uPA–uPAR can interact with transmembrane proteins to modify multiple signal transduction pathways and influence a wide variety of cellular behaviours. Correlative clinical data show elevated uPA–uPAR in oral tumour tissues, with tumours exhibiting high levels of both uPA and uPAR as the most invasive. Combined in vitro, pre-clinical and clinical data support the need for further analysis of uPA–uPAR as a prognostic indicator as well as a potential therapeutic target in OSCC.

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