scholarly journals Induction of apoptosis in human cancer cell lines by the novel anthracenyl-amino acid topoisomerase I inhibitor NU/ICRF 505

1996 ◽  
Vol 74 (3) ◽  
pp. 374-379 ◽  
Author(s):  
I Meikle ◽  
J Cummings ◽  
JS Macpherson ◽  
JF Smyth
Keyword(s):  
Amino Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Topoisomerase I ◽  
Human Cancer ◽  
The Novel ◽  
Human Cancer Cell ◽  
Topoisomerase I Inhibitor ◽  
Human Cancer Cell Lines ◽  
Induction Of Apoptosis

Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines

2013 ◽  
Vol 10 (7) ◽  
pp. 1260-1268 ◽  
Author(s):  
Motohiko Ukiya ◽  
Takuma Kawaguchi ◽  
Kenta Ishii ◽  
Eri Ogihara ◽  
Yosuke Tachi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Amino Acid Conjugate ◽  
Acid Conjugate ◽  
Derivatives Of

Synthesis of piperine–amino acid ester conjugates and study of their cytotoxic activities against human cancer cell lines

2010 ◽  
Vol 21 (1) ◽  
pp. 38-46 ◽  
Author(s):  
V. Rama Subba Rao ◽  
G. Suresh ◽  
R. Ranga Rao ◽  
K. Suresh Babu ◽  
G. Chashoo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Acid Ester ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Amino Acid Ester ◽  
Cytotoxic Activities ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Probing for the Pharmacophore of the Cytotoxic Neoclerodane Salvileucalin B

2012 ◽  
Vol 65 (12) ◽  
pp. 1679 ◽  
Author(s):  
Nora Heinrich ◽  
Martin G. Banwell ◽  
Anthony C. Willis ◽  
Ian A. Cade ◽  
Robert J. Capon ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
The Novel ◽  
Structural Elements ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Pentacyclic Core

The novel [4.3.1]propelladiene 2, which embodies the key structural elements of the pentacyclic core of the cytotoxic neoclerodane salvileucalin B (1), has been prepared using a rhodium-catalysed intramolecular Büchner reaction as the key step. Compound 2 and the readily obtained derivatives 12–17 all proved to be essentially inactive when tested against a panel of four human cancer cell lines. Furthermore, not one of these compounds was a P-gp inhibitor.

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