scholarly journals Low-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver

1995 ◽  
Vol 72 (1) ◽  
pp. 31-34 ◽  
Author(s):  
DT Griffin ◽  
NJF Dodd ◽  
S Zhao ◽  
BR Pullan ◽  
JV Moore
Keyword(s):  
Hepatic Metastases ◽  
Normal Liver ◽  
Electrical Current ◽  
Current Therapy ◽  
Preclinical Studies ◽  
Low Level ◽  
Direct Electrical Current

Safe control of palmoplantar hyperhidrosis with direct electrical current

2002 ◽  
Vol 41 (9) ◽  
pp. 602-605 ◽  
Author(s):  
Yunus Karakoç ◽  
Ertuğrul H. Aydemir ◽  
M. Tunaya Kalkan ◽  
Gaye Ünal
Keyword(s):  
Electrical Current ◽  
Direct Electrical Current ◽  
Safe Control

Stimulation of bone formation by direct electrical current in an orthopedically expanded suture in the rat

2010 ◽  
Vol 40 (2) ◽  
pp. 106 ◽  
Author(s):  
Tancan Uysal ◽  
Mihri Amasyali ◽  
Huseyin Olmez ◽  
Yildirim Karslioglu ◽  
Omer Gunhan
Keyword(s):  
Bone Formation ◽  
Electrical Current ◽  
Direct Electrical Current ◽  
Stimulation Of

scholarly journals Activity of fixed direct electrical current in experimental Staphylococcus aureus foreign-body osteomyelitis

2019 ◽  
Vol 93 (2) ◽  
pp. 92-95 ◽  
Author(s):  
Suzannah M. Schmidt-Malan ◽  
Cassandra L. Brinkman ◽  
Kerryl E. Greenwood-Quaintance ◽  
Melissa J. Karau ◽  
Jayawant N. Mandrekar ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Foreign Body ◽  
Electrical Current ◽  
Direct Electrical Current

Initial report of treatment of uveal melanoma with hepatic metastases with yttrium90 internal radiation followed by ipilimumab and nivolumab.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 10025-10025 ◽  
Author(s):  
David R. Minor ◽  
Takami Sato ◽  
Marlana M. Orloff ◽  
Jason J. Luke ◽  
David J. Eschelman ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Checkpoint Inhibitors ◽  
Package Insert ◽  
Hepatic Metastases ◽  
Normal Liver ◽  
Hepatic Artery Infusion ◽  
Hepatic Toxicity ◽  
Internal Radiation ◽  
Initial Report ◽  
Grade 3

10025 Background: Hepatic metastases from uveal melanoma have no established therapy, with a median survival of only 6-12 months. To date therapy with checkpoint inhibitors has yielded minimal results. To take advantage of possible synergy between radiation and immunotherapy we treated patients with yttrium90 internal radiation followed by immunotherapy. Methods: Patients received yttrium90 (Sir-Spheres) via hepatic artery infusion in two treatments, one to each lobe 3-4 weeks apart, followed in 3-6 weeks by ipilimumab and nivolumab for 4 doses, then nivolumab maintenance. Results: We are presenting interim results because of the excessive toxicity seen when these FDA-approved modalities were used in sequence with the FDA-approved dosages. Initially dosing of yttrium90 (Y90) followed the package insert “BSA method” but after 8 patients we had 5 cases of grade 3-4 hepatic toxicity; in 4 cases the toxicity was observed after just the Y90. One case of cirrhosis occurred in a patient whose liver received 40-45Gy; her cirrhosis was felt most likely due to the Y90. Y90 dosing was then reduced to limit dosage to normal liver to 35Gy, and none of the next 5 patients have had more than grade 2 hepatic toxicity. Dosage to the normal liver is approximated by the MIRD formula: Actual delivered liver dose [Gy] = 50 * Administered activity [GBq] * (1 – Lung shunt fraction) / kg of treated liver. If calculated dose was > 35GY, dosage in GBq is reduced proportionally. Toxicity in the first 5 patients to receive immunotherapy included one grade 4, two grade 3 and two grade 2 hepatic toxicities, and only 3 of the 5 patients received more than one dose of ipilimumab. We then reduced dosing of ipilimumab from 3mg/kg x 4 to 1mg/kg x 4 because of this excessive autoimmune toxicity. Of 13 patients, 10 received both Y90 and immunotherapy, and 3 had responses (1 CR, 2 PR) with 3 patients stable > 5months. Median progression-free survival for all patients is 27 weeks and median overall survival is greater than 48 weeks. Treatment with Y90 produced an over 50% fall in peripheral blood lymphocytes which was reversed in most patients by the immunotherapy. Conclusions: With dose modifications this therapy appears feasible and objective tumor responses were seen. Sequential therapy with Y90 and immunotherapy appears tolerable if radiation to normal liver is limited to 35Gy and ipilimumab dose is 1mg/kg. Clinical trial information: NCT02913417.

Movement Disorders

2012 ◽  
Author(s):  
Mark Hallett ◽  
Alfredo Berardelli
Keyword(s):  
Movement Disorders ◽  
Electrical Current ◽  
Intracortical Inhibition ◽  
Clinical Results ◽  
Clinical Role ◽  
Direct Electrical Current ◽  
Therapeutic Uses ◽  
Low Levels ◽  
The Brain

This article focuses on the potential therapeutic uses of transcranial magnetic stimulation (TMS) in movement disorders. The brain can be stimulated with low levels of direct electrical current, called direct current polarization (tDCS). High-frequency repetitive TMS might increase brain excitability and be used for therapy in Parkinson's disease. Single sessions with TMS, however, have not proven to be very effective. Treatment with tDCS has been performed in some open studies with some success, but these results need confirmation. Physiological findings in dystonia reveal a decrease in intracortical inhibition. There have been a few studies of patients with Tourette's syndrome with mixed results. To date, clinical results with TMS in movement disorders have been mixed, and more work will be needed to clarify the potential clinical role of TMS.

scholarly journals An Extensive Review of Multilevel Inverters Based on Their Multifaceted Structural Configuration, Triggering Methods and Applications

Electronics ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 433 ◽  
Author(s):  
Suvetha Poyyamani Sunddararaj ◽  
Shriram Srinivasarangan Rangarajan ◽  
Subashini N
Keyword(s):  
Structural Complexity ◽  
Electrical Current ◽  
Sine Wave ◽  
Extensive Review ◽  
Voltage Profile ◽  
Power Electronic Converters ◽  
Multilevel Inverters ◽  
Output Terminal ◽  
Direct Electrical Current ◽  
Asymmetric Hybrid

Power electronic converters are used to transform one form of energy to another. They are classified into four types depending upon the nature of the input and output voltages. The inverter is one among those types; it converts direct electrical current into alternating electrical current at desired frequency. Conventional types of inverters are capable of producing voltage at the output terminal that can only switch between two levels. The range of output voltage generated at the output is low when they are used for high power applications. To improve the voltage profile and efficiency of the overall system, multilevel inverters (MLIs) are introduced. In multilevel inverters the voltage at the output terminal is generated from several DC voltage levels fed at its input. The generated output is more appropriate to a sine wave and the dv/dt rating is also less leading to the reduction in EMI. Though they possess many advantages compared to the conventional inverters, the structural complexity and triggering techniques involved in designing multilevel inverters are high. Many studies are being carried out in defining new topologies of MLI with reduced switch as well as with the implementation of different PWM techniques. This paper will provide an extensive review on variety of MLI configurations based on the parameters such as the number of switches, switching techniques, symmetric, asymmetric, hybrid topologies, configurations based on applications, THD and power quality.

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