scholarly journals Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes

1995 ◽  
Vol 71 (4) ◽  
pp. 676-683 ◽  
Author(s):  
D-w Shen ◽  
S-i Akiyama ◽  
P Schoenlein ◽  
I Pastan ◽  
MM Gottesman
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Hepatoma Cell ◽  
Resistant Cell ◽  
Cross Resistance ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Adenocarcinoma Cells ◽  
High Level

scholarly journals Induction of plasma protein secretion in a newly established human hepatoma cell line.

1983 ◽  
Vol 3 (6) ◽  
pp. 1133-1137 ◽  
Author(s):  
C Chang ◽  
Y Lin ◽  
T W O-Lee ◽  
C K Chou ◽  
T S Lee ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Plasma Proteins ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
Hepatoma Cell Lines ◽  
Hepatocyte Markers

To study the expression and the regulation of hepatocyte markers, we have undertaken to establish human hepatoma cell lines of various phenotypes. We now report the establishment of a new human hepatoma cell line, HA22T/VGH. This cell line has many of the properties of human hepatocellular carcinoma. Only 5 of 15 plasma proteins investigated were detected in the medium of a 10-day-old HA22T/VGH culture. However, when the HA22T/VGH cells and a clonal derivative, C5, were cultured in an aggregated form, all 15 plasma proteins were found in the culture medium. These results indicate that hepatoma cell lines with different phenotypes can be established, and they provide a good experimental framework to investigate differentiation of human hepatocytes.

Induction of plasma protein secretion in a newly established human hepatoma cell line

1983 ◽  
Vol 3 (6) ◽  
pp. 1133-1137
Author(s):  
C Chang ◽  
Y Lin ◽  
T W O-Lee ◽  
C K Chou ◽  
T S Lee ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Plasma Proteins ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Human Hepatoma Cell Line ◽  
Hepatoma Cell Lines ◽  
Hepatocyte Markers

To study the expression and the regulation of hepatocyte markers, we have undertaken to establish human hepatoma cell lines of various phenotypes. We now report the establishment of a new human hepatoma cell line, HA22T/VGH. This cell line has many of the properties of human hepatocellular carcinoma. Only 5 of 15 plasma proteins investigated were detected in the medium of a 10-day-old HA22T/VGH culture. However, when the HA22T/VGH cells and a clonal derivative, C5, were cultured in an aggregated form, all 15 plasma proteins were found in the culture medium. These results indicate that hepatoma cell lines with different phenotypes can be established, and they provide a good experimental framework to investigate differentiation of human hepatocytes.

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