scholarly journals A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines

1992 ◽  
Vol 65 (5) ◽  
pp. 684-690 ◽  
Author(s):  
T Rhodes ◽  
PR Twentyman
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Ethacrynic Acid ◽  
Human Lung ◽  
Resistant Cell ◽  
Human Lung Cancer ◽  
Drug Resistant ◽  
Cisplatin Sensitivity ◽  
Drug Resistant Cell

scholarly journals DIFFERENTIATION OF Ca2+ SIGNALLING BETWEEN ADRIAMYCIN-SENSITIVE AND RESISTANT CELL LINES OF HUMAN LUNG CANCER, SBC-3

1996 ◽  
Vol 17 (1) ◽  
pp. 81-86
Author(s):  
TOMIO KANNO ◽  
NAOTO ASADA ◽  
YOSHIAKI HABARA ◽  
TOMOYUKI ISHIDA ◽  
NAGAHIRO SAIJO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Human Lung ◽  
Resistant Cell ◽  
Human Lung Cancer

scholarly journals GLP2-GLP2R signal affects the viability and EGFR-TKIs sensitivity of PC9 and HCC827 cells

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Bin Song ◽  
Hong Ge ◽  
Chenwei Pu ◽  
Ning Li
Keyword(s):  
Lung Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Cell Lines ◽  
Differentially Expressed Genes ◽  
Resistant Cell ◽  
Differentially Expressed ◽  
Drug Resistant ◽  
Drug Resistant Cell ◽  
Egfr Tkis

Abstract Background The resistance to epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitors (TKIs) therapy is currently the major clinical challenge in the treatment of lung cancer. This study aims to reveal the role of glucagon-like peptide (GLP) 2 and GLP-2 receptor (GLP2R) signaling on the EGFR-TKIs and cisplatin resistance of lung cancer cells. Methods The common differentially expressed genes in PC9 and HCC827 cells that were individually resistant to one of the three EGFR-TKIs (dacomitinib, osimertinib and afatinib) were screened. The data were from GSE168043 and GSE163913. The expression of GLP2R in drug-resistant cells was detected by western blot. The effect of GLP2R expression down- or up-regulation on resistance to dacomitinib, osimertinib, afatinib or cisplatin was measured by CCK-8 and flow cytometry assays. The long-acting analog of GLP-2, teduglutide, treated the parental cells. Results A total of 143 common differentially expressed genes were identified. Compared with the parent cells, the GLP2R expression in drug-resistant cell lines was significantly up-regulated. The exogenous expression of GLP2R in parental cells enhanced cell viability, while knockdown of GLP2R levels in drug-resistant cell lines inhibited cell viability. In addition, teduglutide treatment also enhanced the viability of lung cancer cells. Conclusion GLP2-GLP2R signal may change the sensitivity of cells to EGFR-TKIs and cisplatin. The development of GLP-2 or GLP2R inhibitors may be beneficial to the clinical treatment of lung cancer.

scholarly journals Changes of Surface Antigens in Drug-resistant Human Lung Cancer Cell Lines and Their Susceptibility to LAK Cells.

Haigan ◽  
1995 ◽  
Vol 35 (1) ◽  
pp. 35-41
Author(s):  
Keiji Takahashi ◽  
Kazuya Kondo ◽  
Seiya Saito ◽  
Yoshitaka Kamamura ◽  
Toshihiro Ichimori ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Surface Antigens ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Drug Resistant ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom

Toxins ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 38 ◽  
Author(s):  
Irasema Oroz-Parra ◽  
Mario Navarro ◽  
Karla Cervantes-Luevano ◽  
Carolina Álvarez-Delgado ◽  
Guy Salvesen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Synthetic Peptide ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro

1996 ◽  
Vol 14 (4) ◽  
pp. 351-357 ◽  
Author(s):  
Xin-Hai Pei ◽  
Yoichi Nakanishi ◽  
Koichi Takayama ◽  
Jun Yatsunami ◽  
Feng Bai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Lung Cancer Cell ◽  
Stimulating Factor
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