scholarly journals Micrometastases to axillary lymph nodes from invasive lobular carcinoma of breast: Detection by immunohistochemistry and prognostic significance

1987 ◽  
Vol 56 (6) ◽  
pp. 838-839 ◽  
Author(s):  
M Trojani ◽  
I de Mascarel ◽  
JM Coindre ◽  
F Bonichon
Keyword(s):  
Lymph Nodes ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Prognostic Significance ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

Invasive Lobular Carcinoma Classic Type: Response to Primary Chemotherapy and Survival Outcomes

2005 ◽  
Vol 23 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Massimo Cristofanilli ◽  
Ana Gonzalez-Angulo ◽  
Nour Sneige ◽  
Shu-Wan Kau ◽  
Kristine Broglio ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Nuclear Grade ◽  
Primary Chemotherapy ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Long Term Outcome ◽  
The Impact

Purpose To investigate the impact of histologic type invasive lobular carcinoma (ILC) versus invasive ductal carcinoma (IDC) on response to primary chemotherapy (PC) and long-term outcome. Patients and Methods The study included 1,034 patients with stage II and III breast cancer who participated in six clinical trials of PC at our institution between 1985 and 2002. One hundred twenty-two patients (12%) had ILC and 912 (88%) had IDC. All patients received anthracycline-based PC, and 346 patients (33.5%) also received a taxane as part of PC. Pathologic complete response (pCR) was defined as no evidence of invasive disease in the breast and axillary lymph nodes. Results The median patient age was 48 years (range, 18 to 79 years). Patients with ILC tended to be older (median age, 53 years v 47 years for patients with IDC) and have more hormone-receptor–positive tumors (92% v 62%; P < .001), lower nuclear grade (nuclear grade 3, 16% v 56%; P < .001), and higher stage at diagnosis (10% v 0% with stage IIIB or IIIC disease; P < .001). Patients with ILC were less likely to have a pCR (3% v 15%; P < .001) and had a larger number of involved axillary lymph nodes (41% v 26% had > 3 involved nodes; P = .001). At a median follow-up time of 70 months, ILC patients tended to have longer recurrence-free survival (P = .004) and overall survival (P = .001). Conclusion ILC is characterized by lower rates of pathologic response to PC but better long-term outcomes compared to IDC. pCR might not be a prognostic indicator for this group of patients.

Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis

2021 ◽  
Author(s):  
Guixin Wang ◽  
Shuhao Zhang ◽  
Meiling Wang ◽  
Lin Liu ◽  
Yaqian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Lymph Nodes ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Occult Metastases ◽  
Node Metastases ◽  
Disease Free

Abstract Background: Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases remain controversial. This meta-analysis aimed to evaluate the prognostic significance of occult lymph node metastases in breast cancer.Methods: Studies published published until May, 2020, which retrospectively examined negative lymph nodes by step sectioning and/or immunohistochemistry, were retrieved from MEDLINE, EMBASE, CNKI, and Cochrane Library. The pooled Relative risk (RR) with 95% confidence interval (95% CI) for overall survival (OS) and disease-free survival (DFS) were calculated to appraise the associations between occult metastases and prognosis.Results: The results showed patients with occult metastases in axillary lymph nodes had poorer five-year DFS (RR = 0.930; 95% CI = 0.907–0.954) and OS (RR = 0.972; 95% CI = 0.954–0.990). Furthermore, the DFS (RR = 0.887; 95% CI = 0.810–0.972) and OS (RR = 0.896; 95% CI = 0.856–0.939) of patients with occult metastases were much lower after a ten-year follow-up.Conclusions: Occult metastases in the axillary lymph nodes of patients with breast cancer are associated with poorer disease-free and overall survival. Occult metastases might serve as a predictive factor of survival outcomes in patients with breast cancer.

Prognostic Significance of the Number of Negative Axillary Lymph Nodes in Patients with pT1-2 N0 M0 Breast Cancer: A Population-Based Study

2010 ◽  
pp. no-no
Author(s):  
David Martinez-Ramos ◽  
Javier Escrig-Sos ◽  
Ana Torrella-Ramos ◽  
Miguel Alcalde-Sanchez ◽  
Jose Luis Salvador-Sanchis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Prognostic Significance ◽  
Population Based ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Population Based Study

scholarly journals Prognostic Significance of Ki-67 and p53 Immunoexpression in Breast Carcinoma Patients with Positive Axillary Lymph Nodes

2019 ◽  
Vol 6 (10) ◽  
pp. A487-495
Author(s):  
Lalit Sharma ◽  
◽  
Kafil Akhtar ◽  
Syed Shamshad Ahmad ◽  
Atia Zakaur Rab ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Lymph Nodes ◽  
Prognostic Significance ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Ki 67

scholarly journals Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Guixin Wang ◽  
Shuhao Zhang ◽  
Meiling Wang ◽  
Lin Liu ◽  
Yaqian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Occult Metastases ◽  
Node Metastases

Abstract Background Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases have shown controversial results. This meta-analysis aimed to evaluate the prognostic significance of occult lymph node metastases in breast cancer. Methods Studies published until May, 2020, which retrospectively examined negative lymph nodes by stepsectioning and/or immunohistochemistry, were retrieved from MEDLINE, EMBASE, CNKI, and Cochrane Library databases. The pooled Relative Risk (RR) with 95% confidence interval (95% CI) for overall survival (OS) and disease-free survival (DFS) were calculated to examine the associations between occult metastases and prognosis. Results Patients with occult metastases in axillary lymph nodes had poorer five-year DFS (RR = 0.930; 95% CI = 0.907–0.954) and OS (RR = 0.972; 95% CI = 0.954–0.990). Furthermore, the DFS (RR = 0.887; 95% CI = 0.810–0.972) and OS (RR = 0.896; 95% CI = 0.856–0.939) of patients with occult metastases were significantly lower after a ten-year follow-up. Conclusions Occult metastases in the axillary lymph nodes are associated with poorer DFS andOS of patients with breast cancer. Occult metastases might serve as a predictive factor of survival outcomes in patients with breast cancer.

scholarly journals Malignant phyllodes tumor in the right breast and invasive lobular carcinoma within fibroadenoma in the other: case report

2000 ◽  
Vol 118 (2) ◽  
pp. 46-48 ◽  
Author(s):  
Luiz Henrique Gebrim ◽  
Júlio Roberto de Macedo Bernardes Júnior ◽  
Afonso Celso Pinto Nazário ◽  
Cláudio Kemp ◽  
Geraldo Rodrigues de Lima
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Invasive Lobular Carcinoma ◽  
Hormone Replacement ◽  
Lobular Carcinoma ◽  
Phyllodes Tumor ◽  
Left Breast ◽  
Axillary Lymph ◽  
Axillary Lymphadenectomy ◽  
The Right

CONTEXT: The malignant variety of the phyllodes tumor is rare. The occurrence of invasive lobular carcinoma within fibroadenoma is rare as well. DESIGN: Case report. CASE REPORT: A 58-year-old black female patient was referred to the Mastology unit of the Department of Gynecology, Federal University of São Paulo / Escola Paulista de Medicina, in February 1990, presenting an ulcerated tumor in the right breast with fast growth over the preceding six months. She was a virgin, with meno-pause at the age of 45 years and had not undergone hormone replacement treatment. The physical examination showed, in her right breast, an ulcerated tumor of 20 x 30 cm which was not adher-ent to the muscle level, multilobular and with fibroelastic consistency. The axillary lymph nodes were not palpable. The left breast showed a 2 x 3 cm painless, movable nodule, with well-defined edges, and fibroelastic consistency. We performed left-breast mammography, which showed several nodules with well-defined edges, the largest being 2 x 3 cm and exhibiting rough calcification and grouped microcalcifications within it. The patient underwent a frozen biopsy that showed a malignant variant of the phyllodes tumor in the right breast and fibroadenoma in the left one. After that, we performed a total mastectomy in the right breast and an excision biopsy in the left one. Paraffin study confirmed the frozen biopsy result from the right breast, yet we observed that in the interior of the fibroadenoma that was removed on the left, there was a focal area of invasive lobular carcinoma measuring 0.4 cm. The patient then underwent a modi-fied radical mastectomy with total axillary lymphadenectomy. None of the 21 dissected lymph nodes showed evidence of metastasis. In the follow-up, the patient evolved asymptomatically and with normal physical and laboratory examination results up to July 1997.

scholarly journals Micrometastases to axillary lymph nodes from carcinoma of breast: Detection by immunohistochemistry and prognostic significance

1987 ◽  
Vol 55 (3) ◽  
pp. 303-306 ◽  
Author(s):  
M Trojani ◽  
I de Mascarel ◽  
F Bonichon ◽  
JM Coindre ◽  
G Delsol
Keyword(s):  
Lymph Nodes ◽  
Prognostic Significance ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph
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