scholarly journals Biological properties of a spontaneous murine tumour (STS) suitable for in vitro-in vivo studies

1985 ◽  
Vol 52 (1) ◽  
pp. 123-126
Author(s):  
T E Wheldon ◽  
H C Walker ◽  
J Burgin ◽  
A S Michalowski ◽  
C Rowlatt
Keyword(s):  
Biological Properties ◽  
In Vivo Studies ◽  
Murine Tumour

scholarly journals Identification of Structurally Similar Phytochemicals to Quercetin with High SIRT1 Binding Affinity and Improving Diabetic Wound Healing by Using In silico Approaches

2021 ◽  
Vol 12 (6) ◽  
pp. 7621-7632
Keyword(s):  
Wound Healing ◽  
In Silico ◽  
Binding Free Energy ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Diabetic Wound ◽  
Binding Modes ◽  
Diabetic Wound Healing

Diabetes Mellitus is the most prevalent metabolic disorder that is increasing at an alarming rate worldwide. The unregulated glucose level leads to various types of health disorders, and one of the major diabetic complications is delayed wound healing. Due to the more side effects of synthetic drugs, there is a need to explore plants and their phytochemicals for medicinal purposes. It was found that Quercetin, a flavonoid, increases the rate of diabetic wound healing by enhancing the expression of SIRT1. This demands more insight towards Quercetin and its similar compounds, as it is hypothesized that similar compounds may have similar biological properties. Thus similarity searching was done to identify the most similar compounds of Quercetin, and then the molecular docking of the screened compounds was performed using AutoDock Vina. The unique ligands were docked into the active site of SIRT1 protein (PDB ID: 4ZZJ). The binding free energy of the interacting ligand with the protein was estimated. Six compounds were identified which possess the maximum structural similarity with Quercetin, and upon docking, it was found that gossypetin and herbacetin have similar binding modes and binding energy as that of Quercetin (-7.5 kcal/mol). Therefore, the hypothesis has been validated by in silico analysis. Our study identified two phytochemicals, Gossypetin, and Herbacetin which can prove beneficial for improving diabetic wound healing but needs to be validated further by in vitro and in vivo studies.

scholarly journals Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials—A Minireview

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3224 ◽  
Author(s):  
Beata Kaczmarek
Keyword(s):  
Physicochemical Properties ◽  
Tannic Acid ◽  
Phenolic Acid ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Biomedical Sciences ◽  
Simplex Virus

As a phenolic acid, tannic acid can be classified into a polyphenolic group. It has been widely studied in the biomedical field of science because it presents unique antiviral as well as antibacterial properties. Tannic acid has been reported to present the activity against Influeneza A virus, Papilloma viruses, noroviruses, Herpes simplex virus type 1 and 2, and human immunodeficiency virus (HIV) as well as activity against both Gram-positive and Gram-negative bacteria as Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Enterococcus faecalis, Pseudomonas aeruginosa, Yersinia enterocolitica, Listeria innocua. Nowadays, compounds of natural origin constitute fundaments of material science, and the trend is called “from nature to nature”. Although biopolymers have found a broad range of applications in biomedical sciences, they do not present anti-microbial activity, and their physicochemical properties are rather poor. Biopolymers, however, may be modified with organic and inorganic additives which enhance their properties. Tannic acid, like phenolic acid, is classified into a polyphenolic group and can be isolated from natural sources, e.g., a pure compound or a component of a plant extract. Numerous studies have been carried out over the application of tannic acid as an additive to biopolymer materials due to its unique properties. On the one hand, it shows antimicrobial and antiviral activity, while on the other hand, it reveals promising biological properties, i.e., enhances the cell proliferation, tissue regeneration and wound healing processes. Tannic acid is added to different biopolymers, collagen and polysaccharides as chitosan, agarose and starch. Its activity has been proven by the determination of physicochemical properties, as well as the performance of in vitro and in vivo studies. This systematics review is a summary of current studies on tannic acid properties. It presents tannic acid as an excellent natural compound which can be used to eliminate pathogenic factors as well as a revision of current studies on tannic acid composed with biopolymers and active properties of the resulting complexes.

scholarly journals Pleiotropic Biological Effects of Dietary Phenolic Compounds and their Metabolites on Energy Metabolism, Inflammation and Aging

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 596 ◽  
Author(s):  
María del Carmen Villegas-Aguilar ◽  
Álvaro Fernández-Ochoa ◽  
María de la Luz Cádiz-Gurrea ◽  
Sandra Pimentel-Moral ◽  
Jesús Lozano-Sánchez ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Phenolic Compounds ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Wide Range ◽  
High Prevalence

Dietary phenolic compounds are considered as bioactive compounds that have effects in different chronic disorders related to oxidative stress, inflammation process, or aging. These compounds, coming from a wide range of natural sources, have shown a pleiotropic behavior on key proteins that act as regulators. In this sense, this review aims to compile information on the effect exerted by the phenolic compounds and their metabolites on the main metabolic pathways involved in energy metabolism, inflammatory response, aging and their relationship with the biological properties reported in high prevalence chronic diseases. Numerous in vitro and in vivo studies have demonstrated their pleiotropic molecular mechanisms of action and these findings raise the possibility that phenolic compounds have a wide variety of roles in different targets.

scholarly journals A Comprehensive Review on Physiological Effects of Curcumin

Drug Research ◽  
2020 ◽  
Vol 70 (10) ◽  
pp. 441-447
Author(s):  
Rabiya Ahsan ◽  
Md Arshad ◽  
Mohammad Khushtar ◽  
Mohd Afroz Ahmad ◽  
Mohammad Muazzam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Curcuma Longa ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Intracellular Signalling Pathways ◽  
Excellent Safety Profile ◽  
Cardiac Disorders ◽  
Indian Food

AbstractTurmeric (Curcuma longa Linn) is an herbal medicine which is traditionally used as a spice, food colouring or flavouring agent and widely used for several diseases such as biliary disorders, cough, hepatic disorders, rheumatism, wound healing, sinusitis, diabetes, cardiac disorders and neurological disorder. It belongs to the Zingiberaceae family. Turmeric is a popular domicile remedy used in Indian food, is mainly a native of south-east Asia, is widely cultivated in India, Sri Lanka, Indonesia, China, Jamaica , Peru, Haiti and Taiwan and it is very less expensive. Curcumin is the main principle of turmeric. Curcumin has shown various biological properties pre-clinically and clinically. Curcumin is a highly pleiotropic molecule which can be modulators of various intracellular signalling pathways that maintain cell growth. It has been reported as anti-inflammatory, anti-angiogenic, antioxidant, wound healing, anti-cancer, anti-Alzheimer and anti-arthritis and possesses an excellent safety profile. All previous review articles on curcumin have collected the biological/pharmacological activities but this review article summarises the most interesting in vitro and in vivo studies of curcumin on most running diseases around the whole world.

Photosensitization by the Near-IR-absorbing Photosensitizer Lutetium Texaphyrin: Spectroscopic, In Vitro and In Vivo Studies

1998 ◽  
Vol 02 (05) ◽  
pp. 383-390 ◽  
Author(s):  
GENADY KOSTENICH ◽  
TANYA BABUSHKINA ◽  
ADINA LAVI ◽  
YAKOV LANGZAM ◽  
ZVI MALIK ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Structural Damage ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Outer Cell ◽  
Lipid Bilayer Membranes ◽  
Photofrin Ii ◽  
Ionic Imbalance

The spectroscopic and biological properties of the new photosensitizer lutetium texaphyrin (Lu-Tex) were assessed in vitro and in vivo on a C26 colon carcinoma model, in comparison with hematoporphyrin (Hp), photofrin II (PII) and chlorin e 6( Chl ). Strong binding of Lu-Tex to lipid bilayer membranes was observed. The results of confocal fluorescence microscopy on C26 cells showed that Lu-Tex was localized in small vesicles in the cytoplasm, possibly in the lysosomes, while Chl and Hp were distributed in larger cytoplasmic vesicles attributed to mitochondria. Scanning electron microscopy and X-ray microanalysis revealed that photodynamic therapy with Lu-Tex induced only slight damage to the cell membrane, leading to a delayed cell response. Chl and Hp caused significant structural damage to the outer cell membrane, resulting in ionic imbalance and fast cell death. The in vitro quantitative assessment of the relative efficiency per absorbed photon of the sensitizers revealed that Lu-Tex was less effective than Chl and Hp . However, the results of our in vivo study showed that at the same light and drug doses the anti-tumor efficiency of the agents was in the following order: Lu-Tex > Chl > PII . The strong in vivo anti-tumor effect of Lu-Tex can be explained by its higher integrated absorption in the long-wavelength range.

scholarly journals Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

2019 ◽  
Vol 17 (3) ◽  
pp. 247-267 ◽  
Author(s):  
Muneeb U. Rehman ◽  
Adil Farooq Wali ◽  
Anas Ahmad ◽  
Sheeba Shakeel ◽  
Saiema Rasool ◽  
...  
Keyword(s):  
Natural Products ◽  
Large Scale ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Preclinical Models ◽  
Neuroprotective Effects ◽  
Neuroprotective Strategies ◽  
Inflammatory Processes

Nature has bestowed mankind with surplus resources (natural products) on land and water. Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. These natural products have been experimentally documented to possess various biological properties such as antioxidant, anti-inflammatory and anti-apoptotic activities. In vitro and in vivo studies have further established the usefulness of natural products in various preclinical models of neurodegenerative disorders. Natural products include phytoconstituents, like polyphenolic antioxidants, found in herbs, fruits, nuts, vegetables and also in marine and freshwater flora. These phytoconstituents may potentially suppress neurodegeneration and improve memory as well as cognitive functions of the brain. Also, they are known to play a pivotal role in the prevention and cure of different neurodegenerative diseases, such as Alzheimer’s disease, epilepsy, Parkinson’s disease and other neuronal disorders. The large-scale neuro-pharmacological activities of natural products have been documented due to the result of either the inhibition of inflammatory processes, or the up-regulation of various cell survival proteins or a combination of both. Due to the scarcity of human studies on neuroprotective effects of natural products, this review focuses on the various established activities of natural products in in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications using the available knowledge in the literature.

Nanocarriers for Vaccine and Gene Delivery Application

2018 ◽  
pp. 381-414 ◽  
Author(s):  
Behiye Şenel ◽  
Gülay Büyükköroğlu
Keyword(s):  
Genetic Material ◽  
Biological Properties ◽  
Target Site ◽  
Inorganic Nanoparticles ◽  
In Vivo Studies ◽  
Polymeric Systems ◽  
Design And Synthesis ◽  
Vaccine Antigens

Nanocarriers with various compositions and biological properties are frequently used systems for in-vitro/in-vivo vaccination and gene transfer. In recent years, developments in nanotechnology have focused on the design and synthesis of nanocarriers that have new properties and can be modified for gene and vaccine delivery. In the favorable results obtained from in-vivo studies performed, they increase interest in these developments and pave the way for their therapeutic use. Nanocarriers have become increasingly important because they can stabilize vaccine antigens and serve as adjuvants, with the advantage of easily transporting genetic material to the target site. In nanocarriers, the molecules involved are adsorbed to the surface or encapsulated in particulates. At the same time, surface modification of nanoparticles allows these systems to carry cargo molecules easily to target site. Among the most studied nanocarriers, lipidic and polymeric systems dendrimers, inorganic nanoparticles, cyclodextrins, cell penetration peptides, and ISCOMs are attracting attention.

Biological properties of terpinolene evidenced by in silico, in vitro and in vivo studies: A systematic review

Phytomedicine ◽  
2021 ◽  
Vol 93 ◽  
pp. 153768
Author(s):  
Isis Oliveira Menezes ◽  
Jackelyne Roberta Scherf ◽  
Anita Oliveira Brito Pereira Bezerra Martins ◽  
Andreza Guedes Barbosa Ramos ◽  
Jullyana de Souza Siqueira Quintans ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Silico ◽  
Biological Properties ◽  
In Vivo Studies

Preclinical assessment of chitosan–polyvinyl alcohol–graphene oxide nanocomposite scaffolds as a wound dressing

2021 ◽  
pp. 096739112110292
Author(s):  
Arash Montazeri ◽  
Fariba Saeedi ◽  
Yaser Bahari ◽  
Ahmad Ahmadi Daryakenari
Keyword(s):  
Graphene Oxide ◽  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Nanocomposite Scaffolds

The present research aimed to examine the biological properties of chitosan (CS)–polyvinyl alcohol (PVA) scaffolds reinforced with graphene oxide (GO) nanosheets, as wound dressings. The scaffolds were characterized by various techniques. The scanning electron microscopy (SEM) and thermogravimetry analyses (TGAs) were used to investigate distribution of the GO within the polymer. The viscoelastic properties were evaluated by dynamic mechanical thermal analysis (DMTA) to examine the quality of a wound dressing. In vitro and in vivo studies were conducted to assess the biocompatibility of the scaffolds as wound dressing. The cell viability and proliferation results indicated that mouse fibroblast cells (L929) could adhere on the 50CS–50PVA/3 wt% GO scaffold. Herewith, the fabricated CS–PVA–GO nanocomposite scaffolds are suggested as promising biomaterials for skin tissue engineering and wound dressing.

scholarly journals Resin matrix ceramics – mechanical, aesthetic and biological properties

2021 ◽  
Vol 69 ◽  
Author(s):  
Mariana ALVES DE LUCENA ◽  
Adriano RELVAS ◽  
Mauro LEFRANÇOIS ◽  
Marcos VENÍCIO AZEVEDO ◽  
Pablo SOTELO ◽  
...  
Keyword(s):  
Glass Ceramics ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Resin Matrix ◽  
Refractory Compounds ◽  
Pubmed Database ◽  
The Us ◽  
Internal Adaptation

ABSTRACT Resin matrix ceramics consist in a polymeric matrix with predominantly inorganic refractory compounds which may include porcelain, glass, ceramics, and glass ceramics, and are divided into three subgroups: Nanoceramics, Vitroceramics, and Zirconia-silica. The aim of this study was to compare, through a literature review, the mechanical and biological properties of resin matrix ceramics, with glass matrix ceramics and polycrystalline ceramics. After reviewing 44 articles found in the US National Library of Medicine (PubMed) database (studies published in English, human clinical studies, in vitro or in vivo studies) that evaluated some properties of this material, such as elasticity modulus, wear resistance, adhesiveness, stain resistance and hardness, this article concluded that, although they belong to the same group, resin matrix ceramics are different from each other due to their microstructures. Moreover, when compared to other ceramic groups, it showed some superior properties, such as flexural strength, fatigue strength and internal adaptation.

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