scholarly journals Enhanced Fc receptor expression by a sub-population of murine intra-tumour macrophages following intravenous Corynebacterium parvum therapy

1983 ◽  
Vol 47 (6) ◽  
pp. 797-802 ◽  
Author(s):  
K Moore ◽  
W H McBride
Keyword(s):  
Fc Receptor ◽  
Receptor Expression ◽  
Corynebacterium Parvum

Methods for Studying Fc Receptor Expression

ImmunoMethods ◽  
1994 ◽  
Vol 4 (1) ◽  
pp. 4-16 ◽  
Author(s):  
Matyas Sandor ◽  
Michael Hagen ◽  
Richard G. Lynch
Keyword(s):  
Fc Receptor ◽  
Receptor Expression

Human eosinophils and parasitic diseases — III. β-interferon increases eosinophil IgG-Fc receptor expression and capacity

1986 ◽  
Vol 8 (5) ◽  
pp. 479-485 ◽  
Author(s):  
C. De Simone ◽  
M.C. Salvi ◽  
G. Ferrarelli ◽  
G. De Santis ◽  
G. Mango ◽  
...  
Keyword(s):  
Fc Receptor ◽  
Receptor Expression ◽  
Parasitic Diseases

scholarly journals Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis

mAbs ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 848-860 ◽  
Author(s):  
Dilip K. Challa ◽  
Xiaoli Wang ◽  
Héctor Pérez Montoyo ◽  
Ramraj Velmurugan ◽  
Raimund J. Ober ◽  
...  
Keyword(s):  
Fc Receptor ◽  
Receptor Expression ◽  
Neonatal Fc Receptor

scholarly journals Inhibition of Interleukin 10 Signaling after Fc Receptor Ligation and during Rheumatoid Arthritis

2003 ◽  
Vol 197 (11) ◽  
pp. 1573-1583 ◽  
Author(s):  
Jong-Dae Ji ◽  
Ioannis Tassiulas ◽  
Kyung-Hyun Park-Min ◽  
Ani Aydin ◽  
Ingrid Mecklenbräuker ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Complexes ◽  
Inflammatory Responses ◽  
Fc Receptors ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Fc Receptor ◽  
Receptor Expression ◽  
Inflammatory Factors

Interleukin-10 (IL-10) is a potent deactivator of myeloid cells that limits the intensity and duration of immune and inflammatory responses. The activity of IL-10 can be suppressed during inflammation, infection, or after allogeneic tissue transplantation. We investigated whether inflammatory factors suppress IL-10 activity at the level of signal transduction. Out of many factors tested, only ligation of Fc receptors by immune complexes inhibited IL-10 activation of the Jak-Stat signaling pathway. IL-10 signaling was suppressed in rheumatoid arthritis joint macrophages that are exposed to immune complexes in vivo. Activation of macrophages with interferon-γ was required for Fc receptor–mediated suppression of IL-10 signaling, which resulted in diminished activation of IL-10–inducible genes and reversal of IL-10–dependent suppression of cytokine production. The mechanism of inhibition involved decreased cell surface IL-10 receptor expression and Jak1 activation and was dependent on protein kinase C delta. These results establish that IL-10 signaling is regulated during inflammation and identify Fc receptors and interferon-γ as important regulators of IL-10 activity. Generation of macrophages refractory to IL-10 can contribute to pathogenesis of inflammatory and infectious diseases characterized by production of interferon-γ and immune complexes.

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