scholarly journals Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight into future directions

2017 ◽  
Vol 7 (9) ◽  
pp. e603-e603 ◽  
Author(s):  
C A van der Weyden ◽  
S A Pileri ◽  
A L Feldman ◽  
J Whisstock ◽  
H M Prince
Keyword(s):  
Historical Perspective ◽  
Therapeutic Targeting ◽  
Future Directions ◽  
Insight Into

Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead

2019 ◽  
Vol 26 (8) ◽  
pp. 1311-1327 ◽  
Author(s):  
Pala Rajasekharreddy ◽  
Chao Huang ◽  
Siddhardha Busi ◽  
Jobina Rajkumari ◽  
Ming-Hong Tai ◽  
...  
Keyword(s):  
Nanoparticle Synthesis ◽  
Research Field ◽  
Synthesis Methods ◽  
Synthetic Approach ◽  
Future Directions ◽  
The Road ◽  
New Methods ◽  
Recent Developments ◽  
Theranostic Applications ◽  
Insight Into

With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods. In this article, we summarize the recent research progresses related to green synthesized nanoparticles for cancer theranostic applications, and we also conclude with a look at the current challenges and insight into the future directions based on recent developments in these areas.

„Viel Papier beschrieben / Und im Irrtum geblieben“?

Der Staat ◽  
2020 ◽  
Vol 59 (3) ◽  
pp. 451-462
Author(s):  
Reinhard Mehring
Keyword(s):  
Historical Perspective ◽  
Legal Doctrine ◽  
Meaningful Life ◽  
First Time ◽  
Insight Into

Kelsens „reine Rechtslehre“ abstrahiert von metajuristischen Einflüssen. Parallel zur entstehenden Kelsen-Gesamtausgabe liegt nun endlich eine überaus materialreiche, auf umfassenden Recherchen beruhende, ebenso detaillierte wie monumentale Biographie vor, die in knappen und prägnanten Zügen Kelsens umfangreiches Werk und sein schwieriges, in der Karriere wie im Emigrationsschicksal vielfach bedeutsames Leben in seinen Kontexten erschließt. Olechowski historisiert Kelsen ohne psychologisierende oder hagiographische Tendenz. Sein instruktives, nüchternes Gesamtpanorama stellt die Kelsen-Forschung erstmals auf eine solide historisch-biographische Basis. Kelsen’s „absolute legal doctrine“ sets aside any influence that goes beyond the limits of mere jurisdiction. A complete edition of Kelsen’s writings is under progress. Finally also a major biography is available, based on comprehensive and detailed research. It provides concise and accurate insight into Kelsen’s extensive oeuvre. It also contextualizes his often meaningful life as far as his career or his fate as an emigrant are concerned. Olechowski puts Kelsen into a historical perspective without emphasising aspects of psychology or hagiography. His instructive and matter-of-fact overview for the first time puts the research on Kelsen on a firm historical and biographical footing.

scholarly journals Cyber Attacks on Critical Infrastructure

2016 ◽  
pp. 448-465
Author(s):  
Ana Kovacevic ◽  
Dragana Nikolic
Keyword(s):  
Control Systems ◽  
Cyber Security ◽  
Critical Infrastructure ◽  
Cyber Attacks ◽  
Cyber Attack ◽  
Future Directions ◽  
Infrastructure Systems ◽  
Cyber Threats ◽  
Scada Systems ◽  
Insight Into

We are facing the expansion of cyber incidents, and they are becoming more severe. This results in the necessity to improve security, especially in the vulnerable field of critical infrastructure. One of the problems in the security of critical infrastructures is the level of awareness related to the effect of cyberattacks. The threat to critical infrastructure is real, so it is necessary to be aware of it and anticipate, predict, and prepare against a cyber attack. The main reason for the escalation of cyberattacks in the field of Critical Infrastructure (CI) may be that most control systems used for CI do not utilise propriety protocols and software anymore; they instead utilise standard solutions. As a result, critical infrastructure systems are more than ever before becoming vulnerable and exposed to cyber threats. It is important to get an insight into what attack types occur, as this may help direct cyber security efforts. In this chapter, the authors present vulnerabilities of SCADA systems against cyber attack, analyse and classify existing cyber attacks, and give future directions to achieve better security of SCADA systems.

scholarly journals PUBLICATION TREND ON TRAVEL PREFERENCES OF SENIOR TOURISTS FROM 2000 TO 2020

2021 ◽  
Vol 6 (26) ◽  
pp. 172-185
Author(s):  
Nurul Ain Farhana Zainordin ◽  
Syed Muhammad Rafy Syed Jaafar ◽  
Nurul Diyana Md Khairi
Keyword(s):  
Literature Review ◽  
The Other ◽  
Ageing Population ◽  
Market Segment ◽  
Future Directions ◽  
Tourism Research ◽  
Review Analysis ◽  
Future Direction ◽  
Insight Into

The ageing population is the crucial phenomenon that has led to the new market segment in tourism known as 'senior tourists.' A senior tourist is determined as an older traveller or grey tourist. The number of elderly keeps growing throughout time; hence, grey tourists will be relevant preferences, differing from the younger tourists. This paper aims to evaluate the relevant studies regarding travel preferences that involve senior tourists. The objective is to understand the publication trend behind the development of travel preferences for senior tourists. The findings suggest that the overall travel preferences among senior tourists studied include 12 aspects of travel preferences. Researchers tend to focus on the aspect of accommodation among senior tourists compared to the other elements. At the end of the review, this paper is set out to outline the literature review analysis to provide greater insight into the development of travel preferences among grey tourists in tourism research from 2000 to 2020. This paper's output offers future directions to explore the offer trends and future direction in tourism and behaviour literature.

scholarly journals Trends in the development of miRNA bioinformatics tools

2019 ◽  
Vol 20 (5) ◽  
pp. 1836-1852 ◽  
Author(s):  
Liang Chen ◽  
Liisa Heikkinen ◽  
Changliang Wang ◽  
Yang Yang ◽  
Huiyan Sun ◽  
...  
Keyword(s):  
Hot Spots ◽  
Target Prediction ◽  
Future Directions ◽  
Regulate Gene Expression ◽  
Small Noncoding Rnas ◽  
The Past ◽  
Manual Curation ◽  
Bioinformatics Tools ◽  
Insight Into ◽  
Epigenetic Processes

Abstract MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via recognition of cognate sequences and interference of transcriptional, translational or epigenetic processes. Bioinformatics tools developed for miRNA study include those for miRNA prediction and discovery, structure, analysis and target prediction. We manually curated 95 review papers and ∼1000 miRNA bioinformatics tools published since 2003. We classified and ranked them based on citation number or PageRank score, and then performed network analysis and text mining (TM) to study the miRNA tools development trends. Five key trends were observed: (1) miRNA identification and target prediction have been hot spots in the past decade; (2) manual curation and TM are the main methods for collecting miRNA knowledge from literature; (3) most early tools are well maintained and widely used; (4) classic machine learning methods retain their utility; however, novel ones have begun to emerge; (5) disease-associated miRNA tools are emerging. Our analysis yields significant insight into the past development and future directions of miRNA tools.

Electronic Procurement in the Construction Industry

2012 ◽  
pp. 118-161 ◽  
Author(s):  
Robert Eadie ◽  
Srinath Perera ◽  
George Heaney
Keyword(s):  
Construction Industry ◽  
The State ◽  
Future Directions ◽  
Reference Guide ◽  
Electronic Procurement ◽  
Current State ◽  
Informed Decisions ◽  
The Status ◽  
Insight Into

The benefits of e-business have been widely promoted but the Architecture, Engineering, and Construction (AEC) sector has lagged behind other sectors in the adoption of e-procurement. The prospective benefits for the AEC sector are suggested by the proven advantages of general e-procurement where adoption has been faster and deeper. However, several studies indicated that barely 20% of documentation is tendered electronically, suggesting there are barriers to e-procurement. In order to promote adoption of e-procurement in the AEC sector, it is important to establish the status of the industry and identify the drivers as well as barriers to e-procurement. This chapter provides a detailed discussion of the state of the industry and its drivers and barriers while ranking these according to its importance. It acts as a reference guide to allow those implementing e-procurement in construction to make informed decisions as to where to focus their efforts to achieve successful realisation incorporating the benefits and avoiding the pitfalls in the process. The chapter also provides some insight into the current state, trends, and future directions of e-procurement in the construction industry.

Open Universities Australia

2013 ◽  
pp. 83-98
Author(s):  
Michael Crock ◽  
Janet Baker ◽  
Skye Turner-Walker
Keyword(s):  
Higher Education ◽  
Open Access ◽  
Federal Government ◽  
Technological Innovation ◽  
Teaching And Learning ◽  
Student Loans ◽  
Future Directions ◽  
History Of ◽  
Insight Into ◽  
Future Plans

This chapter analyses the history of, and future directions for, higher education studies undertaken through Open Universities Australia (OUA), Australia’s unique higher education conduit. Founded to provide open access to units that allow individuals to undertake individual units or achieve qualifications from leading Australian universities, and supported by a federal government student loans scheme, OUA’s experience and future plans provide significant insight into the potential and pitfalls of the technological innovation in both higher education distance, and increasingly, on-campus, teaching and learning. The need for an ongoing emphasis on innovation, adaptability, and cooperation in an extraordinarily rapidly changing environment is highlighted.

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