scholarly journals BCR–ABL-specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during second-generation tyrosine-kinase inhibitor therapy

2011 ◽  
Vol 1 (7) ◽  
pp. e30-e30 ◽  
Author(s):  
G Riva ◽  
M Luppi ◽  
C Quadrelli ◽  
P Barozzi ◽  
S Basso ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Acute Lymphoblastic Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Second Generation ◽  
Kinase Inhibitor ◽  
Cytotoxic T Cells ◽  
Lymphoblastic Leukemia ◽  
Tyrosine Kinase Inhibitor Therapy

scholarly journals Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

Blood ◽  
2019 ◽  
Vol 134 (15) ◽  
pp. 1257-1268 ◽  
Author(s):  
Yinghui Zhu ◽  
Xin He ◽  
Yi-Chun Lin ◽  
Haojie Dong ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Tyrosine Kinase ◽  
Cell Survival ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Key Points ◽  
Survival And Growth ◽  
Inhibitor Treatment

Key Points High PRMT1 expression maintains MLL-r ALL cell survival and growth by regulating FLT3 methylation at R972/973. PRMT1 inhibition enhances ablation of MLL-r ALL by tyrosine kinase inhibitor treatment.

Sign in / Sign up

Export Citation Format

Share Document