scholarly journals Pterostilbene suppresses human endometrial cancer cells in vitro by down-regulating miR-663b

2017 ◽  
Vol 38 (10) ◽  
pp. 1394-1400 ◽  
Author(s):  
Ya-ling Wang ◽  
Yuan Shen ◽  
Jian-ping Xu ◽  
Kun Han ◽  
Yan Zhou ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Cells

Lentivirus-Mediated RNA Interference Targeting the Long Noncoding RNA HOTAIR Inhibits Proliferation and Invasion of Endometrial Carcinoma Cells In Vitro and In Vivo

2014 ◽  
Vol 24 (4) ◽  
pp. 635-642 ◽  
Author(s):  
Jiaming Huang ◽  
Peiqi Ke ◽  
Luyan Guo ◽  
Wei Wang ◽  
Hao Tan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Endometrial Cancer ◽  
Endometrial Carcinoma ◽  
Cancer Cells ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Proliferation And Invasion

ObjectiveThe overexpression of long noncoding RNA HOTAIR is associated with various aggressive solid carcinomas. However, its relationship with endometrial carcinoma has not been reported. The present study aimed to investigate the expression of the long noncoding RNA HOTAIR in endometrial carcinoma, its relationship with the carcinoma’s clinicopathologic features, and the biological function of HOTAIR in regulating endometrial cancer cell proliferation and invasion in vitro and in vivo.MethodsThe expression of HOTAIR was detected in different tissues and cell lines by real-time PCR. Lentivirus-mediated HOTAIR-specific shRNAvectors were transfected into endometrial cancer HEC-1A cells. Cell proliferation and colony formation were examined by CCK-8 assays and colony formation assays, respectively. Invasion and migration were examined by Transwell assays. Flow cytometry assay was used to examine the cell cycle. In addition, xenograft model assays were performed to analyze the growth of endometrial cancer cells in vivo.ResultsOur data showed that HOTAIR expression was higher in endometrial cancer cells and tissues than in normal endometrial tissues. HOTAIR expression was closely related to the tumor stage (P= 0.045), myometrial invasion (P= 0.014), and lymph node metastasis (P= 0.033). The down-regulation of HOTAIR resulted in a significant inhibition of cell proliferation, migration, and invasion and in cell cycle arrest at the G0/G1 phase. Furthermore, HOTAIR depletion significantly suppressed the endometrial cancer tumorigenesis in vivo.ConclusionsThis study is the first to suggest that HOTAIR plays an important role in the carcinogenesis of endometrial cancer. Targeting HOTAIR may be a novel therapeutic strategy for endometrial cancer.

DKK3 as a potential tumor suppressor in endometrial cancer cells in vitro and in a mouse model

2011 ◽  
Vol 123 (2) ◽  
pp. 442
Author(s):  
T. Dellinger ◽  
K. Planutis ◽  
D. Jandial ◽  
X. Zi ◽  
B. Monk ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Tumor Suppressor ◽  
Mouse Model ◽  
Cancer Cells ◽  
Potential Tumor Suppressor

12 In vitro actions of steroids on endometrial cancer cells

1985 ◽  
Vol 23 ◽  
pp. 7
Author(s):  
E. Gurpide ◽  
C.F. Holinka ◽  
H. Hata ◽  
A. Gravanis ◽  
F. Schatz ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Cells

scholarly journals Mitochondrial supercomplex assembly promotes breast and endometrial tumorigenesis by metabolic alterations and enhanced hypoxia tolerance

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Kazuhiro Ikeda ◽  
Kuniko Horie-Inoue ◽  
Takashi Suzuki ◽  
Rutsuko Hobo ◽  
Norie Nakasato ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Tricarboxylic Acid Cycle ◽  
Hypoxia Tolerance ◽  
Breast Cancer Patients ◽  
Cancer Cell Growth

Abstract Recent advance in cancer research sheds light on the contribution of mitochondrial respiration in tumorigenesis, as they efficiently produce ATP and oncogenic metabolites that will facilitate cancer cell growth. Here we show that a stabilizing factor for mitochondrial supercomplex assembly, COX7RP/COX7A2L/SCAF1, is abundantly expressed in clinical breast and endometrial cancers. Moreover, COX7RP overexpression associates with prognosis of breast cancer patients. We demonstrate that COX7RP overexpression in breast and endometrial cancer cells promotes in vitro and in vivo growth, stabilizes mitochondrial supercomplex assembly even in hypoxic states, and increases hypoxia tolerance. Metabolomic analyses reveal that COX7RP overexpression modulates the metabolic profile of cancer cells, particularly the steady-state levels of tricarboxylic acid cycle intermediates. Notably, silencing of each subunit of the 2-oxoglutarate dehydrogenase complex decreases the COX7RP-stimulated cancer cell growth. Our results indicate that COX7RP is a growth-regulatory factor for breast and endometrial cancer cells by regulating metabolic pathways and energy production.

Effects of raloxifene hydrochloride on endometrial cancer cells in vitro

2004 ◽  
Vol 93 (3) ◽  
pp. 642-646 ◽  
Author(s):  
M HIBNER ◽  
J MAGRINA ◽  
S LEFLER ◽  
J CORNELLA ◽  
A PIZARRO ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Cells ◽  
Raloxifene Hydrochloride

Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro

1986 ◽  
Vol 155 (4) ◽  
pp. 857-861 ◽  
Author(s):  
Hiromasa Ikegami ◽  
Naoki Terakawa ◽  
Ikuya Shimizu ◽  
Hideo Kano ◽  
Yoshiaki Tanaka ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Cells ◽  
Progesterone Receptors
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