scholarly journals A miRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial–mesenchymal transition

2017 ◽  
Vol 39 (6) ◽  
pp. 1034-1047 ◽  
Author(s):  
Yi-fan Zhao ◽  
Mei-ling Han ◽  
Ya-jie Xiong ◽  
Long Wang ◽  
Yao Fei ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Feedback Loop ◽  
Human Lung ◽  
Epithelial Mesenchymal Transition ◽  
Cathepsin L ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
Paclitaxel Resistance ◽  
Mesenchymal Transition

scholarly journals Chemical Investigation of Diketopiperazines and N-Phenethylacetamide Isolated from Aquimarina sp. MC085 and Their Effect on TGF-β-Induced Epithelial–Mesenchymal Transition

2021 ◽  
Vol 11 (19) ◽  
pp. 8866
Author(s):  
Myong Jin Lee ◽  
Geum Jin Kim ◽  
Myoung-Sook Shin ◽  
Jimin Moon ◽  
Sungjin Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Spectroscopic Data ◽  
Human Lung ◽  
Epithelial Mesenchymal Transition ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
Smad Pathway ◽  
Mesenchymal Transition ◽  
Data Analyses ◽  
Human Lung Cancer Cells

Chemical investigations of Aquimarina sp. MC085, which suppressed TGF-β-induced epithelial–mesenchymal transition (EMT) in A549 human lung cancer cells, led to the isolation of compounds 1–3. Structural characterization using spectroscopic data analyses in combination with Marfey’s analysis revealed that they were two diketopiperazines [cyclo(l-Pro-l-Leu) (1) and cyclo(l-Pro-l-Ile) (2)] and one N-phenethylacetamide (3). Cyclo(l-Pro-l-Leu) (1) and N-phenethylactamide (3) inhibited the TGF-β/Smad pathway and suppressed the metastasis of A549 cells by affecting TGF-β-induced EMT. However, cyclo(l-Pro-l-Ile) (2) downregulated mesenchymal factors via a non-Smad-mediated signaling pathway.

Extract from the Leaves of Toona sinensis Roemor Exerts Potent Antiproliferative Effect on Human Lung Cancer Cells

2002 ◽  
Vol 30 (02n03) ◽  
pp. 307-314 ◽  
Author(s):  
Hui-Chiu Chang ◽  
Wen-Chun Hung ◽  
Ming-Shyan Huang ◽  
Hseng-Kuang Hsu
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Apoptotic Cell ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Lung Fibroblasts ◽  
Human Lung Cancer ◽  
Toona Sinensis

Recent study indicated that the components of Toona sinensis Roemor have potent anti-inflammatory and analgesic effects. These components have also been reported to inhibit the growth of boils in vivo. In this study, we investigated the effect of crude extract from the leaves of Toona sinensis Roemor on the proliferation of A549 lung cancer cells. We found that the extract effectively blocked cell cycle progression by inhibiting the expression of cyclin D1 and E in A549 cells. Additionally, incubation of the extract led to activation of caspase-3-like proteases and apoptotic cell death. Conversely, the extract did not show any significant cytotoxic effect on primarily cultured human foreskin fibroblasts or MRC-5 human lung fibroblasts. Therefore, antiproliferative action of the extract is specific for tumor cells. Our results suggest that the components of Toona sinensis Roemor have potent anticancer effects in vitro and identification of the useful components in the extract may lead to the development of a novel class of anticancer drugs.

scholarly journals Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGF-β signaling

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 5092-5110 ◽  
Author(s):  
Sirichat Kaowinn ◽  
Jeonghyo Kim ◽  
Jaebeom Lee ◽  
Dong Hoon Shin ◽  
Chi-Dug Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Epithelial Mesenchymal Transition ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Mesenchymal Transition ◽  
Human Lung Cancer Cells
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