scholarly journals Multichannel polymer scaffold seeded with activated Schwann cells and bone mesenchymal stem cells improves axonal regeneration and functional recovery after rat spinal cord injury

2017 ◽  
Vol 38 (5) ◽  
pp. 623-637 ◽  
Author(s):  
Er-zhu Yang ◽  
Guo-wang Zhang ◽  
Jian-guang Xu ◽  
Shuai Chen ◽  
Hua Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Schwann Cells ◽  
Axonal Regeneration ◽  
Polymer Scaffold ◽  
Rat Spinal Cord ◽  
Bone Mesenchymal Stem Cells ◽  
Cord Injury

Combination of activated Schwann cells with bone mesenchymal stem cells: the best cell strategy for repair after spinal cord injury in rats

2011 ◽  
Vol 6 (6) ◽  
pp. 707-720 ◽  
Author(s):  
De-Xiang Ban ◽  
Guang-Zhi Ning ◽  
Shi-Qing Feng ◽  
Ying Wang ◽  
Xian-Hu Zhou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Schwann Cells ◽  
Bone Mesenchymal Stem Cells ◽  
Cord Injury

Enhanced axonal regeneration by transplanted Wnt3a-secreting human mesenchymal stem cells in a rat model of spinal cord injury

2017 ◽  
Vol 159 (5) ◽  
pp. 947-957 ◽  
Author(s):  
Dong Kwang Seo ◽  
Jeong Hoon Kim ◽  
Joongkee Min ◽  
Hyung Ho Yoon ◽  
Eun-Sil Shin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Axonal Regeneration ◽  
Human Mesenchymal Stem Cells ◽  
Cord Injury

scholarly journals Effects of Magnetically Guided, SPIO-Labeled, and Neurotrophin-3 Gene-Modified Bone Mesenchymal Stem Cells in a Rat Model of Spinal Cord Injury

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Rui-Ping Zhang ◽  
Ling-Jie Wang ◽  
Sheng He ◽  
Jun Xie ◽  
Jian-Ding Li
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Therapeutic Effects ◽  
Magnetic Targeting ◽  
Bone Mesenchymal Stem Cells ◽  
Cord Injury

Despite advances in our understanding of spinal cord injury (SCI) mechanisms, there are still no effective treatment approaches to restore functionality. Although many studies have demonstrated that transplantingNT3gene-transfected bone marrow-derived mesenchymal stem cells (BMSCs) is an effective approach to treat SCI, the approach is often low efficient in the delivery of engrafted BMSCs to the site of injury. In this study, we investigated the therapeutic effects of magnetic targeting ofNT3gene-transfected BMSCs via lumbar puncture in a rat model of SCI. With the aid of a magnetic targeting cells delivery system, we can not only deliver the engrafted BMSCs to the site of injury more efficiently, but also perform cells imaging in vivo using MR. In addition, we also found that this composite strategy could significantly improve functional recovery and nerve regeneration compared to transplantingNT3gene-transfected BMSCs without magnetic targeting system. Our results suggest that this composite strategy could be promising for clinical applications.

scholarly journals Repair of spinal cord injury in rats via exosomes from bone mesenchymal stem cells requires sonic hedgehog

2021 ◽  
Vol 18 ◽  
pp. 309-315
Author(s):  
Yijia Jia ◽  
Jianwen Yang ◽  
Tingsheng Lu ◽  
Xingwei Pu ◽  
Qiling Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Sonic Hedgehog ◽  
Bone Mesenchymal Stem Cells ◽  
Cord Injury

scholarly journals Repair of Spinal Cord Injury; Mesenchymal Stem Cells as an Alternative for Schwann Cells

2018 ◽  
Vol 5 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Mehrdad Moosazadeh Moghaddam ◽  
Shahin Bonakdar ◽  
Mohammad Ali Shokrgozar ◽  
Shahab Faghihi
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Schwann Cells ◽  
Cord Injury
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