scholarly journals Ethanol inhibits histaminergic neurons in mouse tuberomammillary nucleus slices via potentiating GABAergic transmission onto the neurons at both pre- and postsynaptic sites

2016 ◽  
Vol 37 (10) ◽  
pp. 1325-1336 ◽  
Author(s):  
Yu Sun ◽  
Shi-yu Jiang ◽  
Jian Ni ◽  
Yan-jia Luo ◽  
Chang-rui Chen ◽  
...  
Keyword(s):  
Gabaergic Transmission ◽  
Tuberomammillary Nucleus ◽  
Histaminergic Neurons

scholarly journals Thyrotropin-releasing hormone-containing axons innervate histaminergic neurons in the tuberomammillary nucleus

2012 ◽  
Vol 1488 ◽  
pp. 72-80 ◽  
Author(s):  
Anna Sárvári ◽  
Erzsébet Farkas ◽  
Andrea Kádár ◽  
Györgyi Zséli ◽  
Tamás Füzesi ◽  
...  
Keyword(s):  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Tuberomammillary Nucleus ◽  
Histaminergic Neurons

scholarly journals α2A adrenoceptor-mediated presynaptic inhibition of GABAergic transmission in rat tuberomammillary nucleus neurons

2013 ◽  
Vol 125 (6) ◽  
pp. 832-842 ◽  
Author(s):  
Michiko Nakamura ◽  
Kyungho Suk ◽  
Maan-Gee Lee ◽  
Il-Sung Jang
Keyword(s):  
Presynaptic Inhibition ◽  
Gabaergic Transmission ◽  
Tuberomammillary Nucleus

scholarly journals Adenosine A1receptors inhibit GABAergic transmission in rat tuberomammillary nucleus neurons

2008 ◽  
Vol 106 (1) ◽  
pp. 361-371 ◽  
Author(s):  
Do-Seop Yum ◽  
Jin-Hwa Cho ◽  
In-Sun Choi ◽  
Michiko Nakamura ◽  
Jong-Ju Lee ◽  
...  
Keyword(s):  
Gabaergic Transmission ◽  
Tuberomammillary Nucleus

scholarly journals Chemogenetic modulation of histaminergic neurons in the tuberomammillary nucleus alters territorial aggression and wakefulness

2021 ◽  
Author(s):  
Fumito Naganuma ◽  
Tadaho Nakamura ◽  
Hiroshi Kuroyanagi ◽  
Masato Tanaka ◽  
Takeo Yoshikawa ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Nrem Sleep ◽  
Cre Recombinase ◽  
Designer Drugs ◽  
Brain Histamine ◽  
Tuberomammillary Nucleus ◽  
Territorial Aggression ◽  
Neuronal Populations ◽  
Histaminergic Neurons ◽  
Aggressive Behaviours

Abstract Designer receptor activated by designer drugs (DREADDs) techniques are widely used to modulate the activities of specific neuronal populations during behavioural tasks. However, DREADDs-induced modulation of histaminergic neurons in the tuberomammillary nucleus (HATMN neurons) has produced inconsistent effects on the sleep–wake cycle, possibly due to the use of Hdc-Cre mice driving Cre recombinase and DREADDs activity outside the targeted region. Moreover, previous DREADDs studies have not examined locomotor activity and aggressive behaviours, which are also regulated by brain histamine levels. In the present study, we investigated the effects of HATMN activation and inhibition on the locomotor activity, aggressive behaviours and sleep–wake cycle of Hdc-Cre mice with minimal non-target expression of Cre-recombinase. Chemoactivation of HATMN moderately enhanced locomotor activity in a novel open field. Activation of HATMN neurons significantly enhanced aggressive behaviour in the resident–intruder test. Wakefulness was increased and non-rapid eye movement (NREM) sleep decreased for an hour by HATMN chemoactivation. Conversely HATMN chemoinhibition decreased wakefulness and increased NREM sleep for 6 hours. These changes in wakefulness induced by HATMN modulation were related to vigilance status transition. These results indicate the influences of HATMN neurons on exploratory activity, territorial aggression, and wake maintenance.

scholarly journals Orexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomammillary Nucleus

2001 ◽  
Vol 21 (23) ◽  
pp. 9273-9279 ◽  
Author(s):  
Krister S. Eriksson ◽  
Olga Sergeeva ◽  
Ritchie E. Brown ◽  
Helmut L. Haas
Keyword(s):  
Tuberomammillary Nucleus ◽  
Histaminergic Neurons
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