scholarly journals Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition

2016 ◽  
Vol 37 (10) ◽  
pp. 1381-1390 ◽  
Author(s):  
Yi-ming Ma ◽  
Yan-min Peng ◽  
Qiong-hua Zhu ◽  
An-hui Gao ◽  
Bo Chao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells

2016 ◽  
Vol 35 (5) ◽  
pp. 2606-2614 ◽  
Author(s):  
SHAOMIN SHI ◽  
PING TAN ◽  
BINGDI YAN ◽  
RONG GAO ◽  
JIANJUN ZHAO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals Tanshinone IIA induces TRAIL sensitization of human lung cancer cells through selective ER stress induction

2016 ◽  
Vol 48 (5) ◽  
pp. 2205-2212 ◽  
Author(s):  
EUN-OK KIM ◽  
SHI EUN KANG ◽  
CHANG RAK IM ◽  
JUN-HEE LEE ◽  
KWANG SEOK AHN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Human Lung ◽  
Tanshinone Iia ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Stress Induction ◽  
Human Lung Cancer Cells

Acid-induced autophagy protects human lung cancer cells from apoptosis by activating ER stress

2015 ◽  
Vol 339 (2) ◽  
pp. 270-279 ◽  
Author(s):  
Wen-Yue Xie ◽  
Xiang-Dong Zhou ◽  
Qi Li ◽  
Ling-Xiu Chen ◽  
Dan-Hua Ran
Keyword(s):  
Lung Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Lingyan Wang ◽  
Jiayun Hou ◽  
Minghuan Zheng ◽  
Lin Shi
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Retinoic Acid Receptor ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
The Core ◽  
Human Lung Cancer Cells ◽  
Receptor Beta

Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the anti-tumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

EFFECTS OF OPIOIDS AND NICOTINE ON APOPTOSIS IN HUMAN LUNG CANCER CELLS

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 548-552
Author(s):  
Rhoda Maneckjee ◽  
Kathleen Dehen ◽  
John D. Minna
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells
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