scholarly journals IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

2017 ◽  
Vol 38 (3) ◽  
pp. 415-423 ◽  
Author(s):  
Mou-ze Liu ◽  
Hai-yan He ◽  
Yue-li Zhang ◽  
Yong-fang Hu ◽  
Fa-zhong He ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Gene Polymorphisms ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Dose Requirement ◽  
Ctla4 Gene ◽  
Tacrolimus Dose

Pretransplant Tacrolimus Dose Requirements Predict Early Posttransplant Dose Requirements in Blood Group AB0-Incompatible Kidney Transplant Recipients

2016 ◽  
Vol 38 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Nauras Shuker ◽  
Femke M. de Man ◽  
Annelies E. de Weerd ◽  
Madelon van Agteren ◽  
Willem Weimar ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Blood Group ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Tacrolimus Dose

scholarly journals Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction?

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Kinga Krzyżowska ◽  
Aureliusz Kolonko ◽  
Piotr Giza ◽  
Jerzy Chudek ◽  
Andrzej Więcek
Keyword(s):  
Risk Factors ◽  
Dose Reduction ◽  
Kidney Transplant ◽  
Multiple Logistic Regression Analysis ◽  
Hemoglobin Concentration ◽  
Blood Levels ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Related Factors ◽  
Tacrolimus Dose

Background. Observational data suggest that the fixed initial recommended tacrolimus (Tc) dosing (0.2 mg/kg/day) results in supratherapeutic drug levels in some patients during the early posttransplant period. The aim of the study was to analyze a wide panel of patient-related factors and their interactions which increase the risk for first Tc blood level > 15 ng/ml. Materials and Methods. We performed a retrospective analysis of 488 consecutive adult kidney transplant recipients who were initially treated with triple immunosuppressive regimen containing tacrolimus twice daily. The analysis included the first assessment of Tc trough blood levels and several demographic, anthropometric, laboratory, and comedication data. Results. The multiple logistic regression analysis showed that age > 55 years, BMI > 24.6 kg/m2, blood hemoglobin concentration > 9.5 g/dl, and the presence of anti-HCV antibodies independently increased the risk for first Tc level > 15 ng/ml. The relative risk (RR) for first tacrolimus level > 15 ng/ml was 1.88 (95% CI 1.35–2.64, p<0.001) for patients with one risk factor and 2.81 (2.02–3.89, p<0.001) for patients with two risk factors. Conclusions. Initial tacrolimus dose reduction should be considered in older, overweight, or obese kidney transplant recipients and in subjects with anti-HCV antibodies. Moreover, dose reduction of tacrolimus is especially important in patients with coexisting multiple risk factors.

CYP3A5andCYP3A4, but notABCB1polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients

2014 ◽  
Vol 15 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Mateusz Kurzawski ◽  
Justyna Dąbrowska ◽  
Krzysztof Dziewanowski ◽  
Leszek Domański ◽  
Magdalena Perużyńska ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Trough Concentrations ◽  
Tacrolimus Dose

Predictors of reduced tacrolimus dose and trough level through 36 months post-transplant among 578 adult primary kidney transplant recipients

2014 ◽  
Vol 28 (4) ◽  
pp. 470-478 ◽  
Author(s):  
Jeffrey J. Gaynor ◽  
Gaetano Ciancio ◽  
Giselle Guerra ◽  
Junichiro Sageshima ◽  
David Roth ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Trough Level ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Tacrolimus Dose
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