scholarly journals Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels

2015 ◽  
Vol 36 (12) ◽  
pp. 1497-1502 ◽  
Author(s):  
Yu-qi Luo ◽  
Xiao-jing Ma ◽  
Ya-ping Hao ◽  
Xiao-ping Pan ◽  
Yi-ting Xu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Blood Glucose ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Inverse Relationship ◽  
Chinese Women ◽  
Serum Osteocalcin ◽  
Nonalcoholic Fatty Liver ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Potential Mechanisms Influencing the Inverse Relationship Between Cannabis and Nonalcoholic Fatty Liver Disease: A Commentary

2019 ◽  
Vol 12 ◽  
pp. 117863881984748 ◽  
Author(s):  
Pratima Dibba ◽  
Andrew A Li ◽  
George Cholankeril ◽  
Muhammad Ali Khan ◽  
Donghee Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Inverse Relationship ◽  
Cannabinoid Receptors ◽  
Endocannabinoid System ◽  
The United States ◽  
Inverse Association ◽  
Nonalcoholic Fatty Liver

Nonalcoholic fatty liver disease (NAFLD) develops when the liver is unable to oxidize or export excess free fatty acids generated by adipose tissue lipolysis, de novo lipogenesis, or dietary intake. Although treatment has generally been centered on reversing metabolic risk factors that increase the likelihood of NAFLD by influencing lifestyle modifications, therapeutic modalities are being studied at the cellular and molecular level. The endocannabinoid system has been of recent focus. The agonism and antagonism of cannabinoid receptors play roles in biochemical mechanisms involved in the development or regression of NAFLD. Exocannabinoids and endocannabinoids, the ligands which bind cannabinoid receptors, have been studied in this regard. Exocannabinoids found in cannabis (marijuana) may have a therapeutic benefit. Our recent study demonstrated an inverse association between marijuana use and NAFLD among adults in the United States. This commentary combines knowledge on the role of the endocannabinoid system in the setting of NAFLD with the findings in our article to hypothesize different potential mechanisms that may influence the inverse relationship between cannabis and NAFLD.

Adiponectin is Inversely Associated with Insulin Resistance in Adolescents with Nonalcoholic Fatty Liver Disease

2021 ◽  
Vol 21 ◽  
Author(s):  
Bin Liu ◽  
Huan Zheng ◽  
Guanghui Liu ◽  
Zhiling Li
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Blood Glucose ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Fasting Blood Glucose ◽  
Significant Determinant ◽  
Nonalcoholic Fatty Liver ◽  
Significant Difference

Background: Insulin resistance(IR) is confirmed as a key feature of nonalcoholic fatty liver disease (NAFLD) in children and adolescents. Numerous studies report that adiponectin (APN) levels are inversely associated with the status of IR in adults with NAFLD. This study aimed to investigate the relationship between serum total APNand homeostasis model assessment insulin resistance(HOMA-IR) in adolescents with NAFLD. Methods: 382 newly-diagnosed NAFLD adolescents, aged 9-16 years old, were enrolled and divided into 3 subgroups according to the APNtertile. Simple and multiple linear regression analyses were performed to assess the correlation between HOMA-IR and APN in boys and girls, respectively. Results: The HOMA-IR values tended to decrease in boys according to APN tertiles: 5.6(4.4-7.3) vs. 5.2(4.6-6.9) vs. 4.9(4.1-5.8) (P<0.01), and there was a significant difference in the HOMA-IR values among three APN tertile subgroups in girls(P<0.01).Univariate analysis showed thatbody mass index, waist circumference, weight-to-height ratio, fasting blood glucose, insulin, triglyceride, and APN were significantly associated with HOMA-IR in boys (P<0.05). In girls, body mass index, fasting blood glucose, insulin, total cholesterol, triglyceride, and APN were significantly associated with HOMA-IR (P<0.05).APN was found to be a significant determinant for HOMA-IR only in boys (β=-0.147, P<0.01). Conclusion: Our findings showed that APN was an independent and significant determinant for increased HOMA-IR in boys with NAFLD. Further studies are needed to explore the underlying mechanisms.

scholarly journals Predicting Nonalcoholic Fatty Liver Disease through a Panel of Plasma Biomarkers and MicroRNAs in Female West Virginia Population

2020 ◽  
Vol 21 (18) ◽  
pp. 6698
Author(s):  
Sneha S. Pillai ◽  
Hari Vishal Lakhani ◽  
Mishghan Zehra ◽  
Jiayan Wang ◽  
Anum Dilip ◽  
...  
Keyword(s):  
Liver Disease ◽  
Blood Glucose ◽  
West Virginia ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Mirna Expression ◽  
Fatty Liver Disease ◽  
Fasting Blood Glucose ◽  
The West ◽  
Nonalcoholic Fatty Liver

(1) Background: Nonalcoholic fatty liver disease (NAFLD) is primarily characterized by the presence of fatty liver, hepatic inflammation and fibrogenesis eventually leading to nonalcoholic steatohepatitis (NASH) or cirrhosis. Obesity and diabetes are common risk factors associated with the development and progression of NAFLD, with one of the highest prevalence of these diseased conditions in the West Virginia population. Currently, the diagnosis of NAFLD is limited to radiologic studies and biopsies, which are not cost-effective and highly invasive. Hence, this study aimed to develop a panel and assess the progressive levels of circulatory biomarkers and miRNA expression in patients at risk for progression to NASH to allow early intervention strategies. (2) Methods: In total, 62 female patients were enrolled and blood samples were collected after 8–10 h of fasting. Computed tomography was performed on abdomen/pelvis following IV contrast administration. The patients were divided into the following groups: Healthy subjects with normal BMI and normal fasting blood glucose (Control, n = 20), Obese with high BMI and normal fasting blood glucose (Obese, n = 20) and Obese with high fasting blood glucose (Obese + DM, n = 22). Based on findings from CT, another subset was created from Obese + DM group with patients who showed signs of fatty liver infiltration (Obese + DM(FI), n = 10). ELISA was performed for measurement of plasma biomarkers and RT-PCR was performed for circulating miRNA expression. (3) Results: Our results show significantly increased levels of plasma IL-6, Leptin and FABP-1, while significantly decreased level of adiponectin in Obese, Obese + DM and Obese + DM(FI) group, as compared to healthy controls. The level of CK-18 was significantly increased in Obese + DM(FI) group as compared to control. Subsequently, the expression of miR-122, miR-34a, miR-375, miR-16 and miR-21 was significantly increased in Obese + DM and Obese + DM(FI) group as compared to healthy control. Our results also show distinct correlation of IL-6, FABP-1 and adiponectin levels with the expression of miRNAs in relation to the extent of NAFLD progression. (4) Conclusion: Our results support the clinical application of these biomarkers and miRNAs in monitoring the progression of NAFLD, suggesting a more advanced diagnostic potential of this panel than conventional methods. This panel may provide an appropriate method for early prognosis and management of NAFLD and subsequent adverse hepatic pathophysiology, potentially reducing the disease burden on the West Virginia population.

scholarly journals Serum Osteocalcin Levels in Children With Nonalcoholic Fatty Liver Disease

2018 ◽  
Vol 66 (1) ◽  
pp. 117-121 ◽  
Author(s):  
Saleh Amin ◽  
Doaa El Amrousy ◽  
Shaymaa Elrifaey ◽  
Rasha Gamal ◽  
Hossam Hodeib
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Serum Osteocalcin ◽  
Nonalcoholic Fatty Liver
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