scholarly journals Fasudil regulates T cell responses through polarization of BV-2 cells in mice experimental autoimmune encephalomyelitis

2014 ◽  
Vol 35 (11) ◽  
pp. 1428-1438 ◽  
Author(s):  
Chan Chen ◽  
Yan-hua Li ◽  
Qiong Zhang ◽  
Jie-zhong Yu ◽  
Yong-fei Zhao ◽  
...  
Keyword(s):  
T Cell ◽  
Experimental Autoimmune Encephalomyelitis ◽  
T Cell Responses ◽  
Autoimmune Encephalomyelitis ◽  
Cell Responses ◽  
Experimental Autoimmune

scholarly journals Rituximab Therapy Reduces Organ-Specific T Cell Responses and Ameliorates Experimental Autoimmune Encephalomyelitis

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17103 ◽  
Author(s):  
Nancy L. Monson ◽  
Petra Cravens ◽  
Rehana Hussain ◽  
Christopher T. Harp ◽  
Matthew Cummings ◽  
...  
Keyword(s):  
T Cell ◽  
Experimental Autoimmune Encephalomyelitis ◽  
T Cell Responses ◽  
Autoimmune Encephalomyelitis ◽  
Cell Responses ◽  
Organ Specific ◽  
Experimental Autoimmune

scholarly journals Correction: PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis

2017 ◽  
Vol 199 (8) ◽  
pp. 3004-3004
Author(s):  
Lindsay M. Webb ◽  
Stephanie A. Amici ◽  
Kyle A. Jablonski ◽  
Himanshu Savardekar ◽  
Amanda R. Panfil ◽  
...  
Keyword(s):  
T Cell ◽  
Experimental Autoimmune Encephalomyelitis ◽  
T Cell Responses ◽  
Selective Inhibitors ◽  
Autoimmune Encephalomyelitis ◽  
Cell Responses ◽  
Experimental Autoimmune

scholarly journals Priming of Myelin-Specific T Cells in the Absence of Dendritic Cells Results in Accelerated Development of Experimental Autoimmune Encephalomyelitis

2020 ◽  
Author(s):  
Thaiphi Luu ◽  
Julie F. Cheung ◽  
Hanspeter Waldner
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Experimental Autoimmune Encephalomyelitis ◽  
T Cell Responses ◽  
Proteolipid Protein ◽  
Cell Receptor ◽  
Autoimmune Encephalomyelitis ◽  
Cell Responses ◽  
Experimental Autoimmune

AbstractExperimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), is predominantly mediated by pro-inflammatory CD4+ T cell responses to CNS antigens, including myelin proteolipid protein (PLP). Dendritic cells (DCs) are considered critical for inducing T cell responses against infectious agents, but the importance of DCs in priming self-reactive CD4+ T cells in autoimmune disease such as MS has been unclear.To determine the requirement of DCs in PLP-specific CD4+ T cell responses and EAE, we genetically deleted CD11c+ DCs in PLP T cell receptor (TCR) transgenic SJL mice constitutively. DC deficiency did not impair the development, selection or the pathogenic function of PLP-specific CD4+ T cells in these mice, and resulted in accelerated spontaneous EAE compared to DC sufficient controls. In addition, using a genetic approach to ablate DCs conditionally in SJL mice, we show that CD11c+ DCs were dispensable for presenting exogenous or endogenous myelin antigen to PLP-specific T cells and for promoting pro-inflammatory T cell responses and severe EAE. Our findings demonstrate that constitutive or conditional ablation of CD11c+ DCs diminished self-tolerance to PLP autoantigen. They further show that in the absence of DCs, non-DCs can efficiently present CNS myelin antigens such as PLP to self-reactive T cells, resulting in accelerated onset of spontaneous or induced EAE.

scholarly journals Opposing T cell responses in experimental autoimmune encephalomyelitis

Nature ◽  
2019 ◽  
Vol 572 (7770) ◽  
pp. 481-487 ◽  
Author(s):  
Naresha Saligrama ◽  
Fan Zhao ◽  
Michael J. Sikora ◽  
William S. Serratelli ◽  
Ricardo A. Fernandes ◽  
...  
Keyword(s):  
T Cell ◽  
Experimental Autoimmune Encephalomyelitis ◽  
T Cell Responses ◽  
Autoimmune Encephalomyelitis ◽  
Cell Responses ◽  
Experimental Autoimmune
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