scholarly journals Potential role of organic anion transporting polypeptide 1B1 (OATP1B1) in the selective hepatic uptake of hematoporphyrin monomethyl ether isomers

2014 ◽  
Vol 36 (2) ◽  
pp. 268-280 ◽  
Author(s):  
Xiu-li Li ◽  
Zi-tao Guo ◽  
Ye-dong Wang ◽  
Xiao-yan Chen ◽  
Jia Liu ◽  
...  
Keyword(s):  
Potential Role ◽  
Organic Anion ◽  
Monomethyl Ether ◽  
Hepatic Uptake ◽  
Organic Anion Transporting Polypeptide ◽  
Hematoporphyrin Monomethyl Ether

scholarly journals Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

2011 ◽  
Vol 25 (1) ◽  
pp. 1-14 ◽  
Author(s):  
W. Edward Visser ◽  
Edith C. H. Friesema ◽  
Theo J. Visser
Keyword(s):  
Thyroid Hormone ◽  
Organic Anion ◽  
Psychomotor Retardation ◽  
Cellular Level ◽  
Monocarboxylate Transporter ◽  
Causative Role ◽  
Organic Anion Transporting Polypeptide ◽  
Neurological Abnormalities ◽  
Knockout Animals

The effects of thyroid hormone (TH) on development and metabolism are exerted at the cellular level. Metabolism and action of TH take place intracellularly, which require transport of the hormone across the plasma membrane. This process is mediated by TH transporter proteins. Many TH transporters have been identified at the molecular level, although a few are classified as specific TH transporters, including monocarboxylate transporter (MCT)8, MCT10, and organic anion-transporting polypeptide 1C1. The importance of TH transporters for physiology has been illustrated dramatically by the causative role of MCT8 mutations in males with psychomotor retardation and abnormal serum TH concentrations. Although Mct8 knockout animals have provided insight in the mechanisms underlying parts of the endocrine phenotype, they lack obvious neurological abnormalities. Thus, the pathogenesis of the neurological abnormalities in males with MCT8 mutations is not fully understood. The prospects of identifying other transporters and transporter-based syndromes promise an exciting future in the TH transporter field.

scholarly journals Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR

2008 ◽  
Vol 103 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Hong Lu ◽  
Supratim Choudhuri ◽  
Kenichiro Ogura ◽  
Iván L. Csanaky ◽  
Xiaohong Lei ◽  
...  
Keyword(s):  
Essential Role ◽  
Organic Anion ◽  
Hepatic Uptake ◽  
Organic Anion Transporting Polypeptide

Fentanyl Pharmacokinetics is not Dependent on Hepatic Uptake by Organic Anion-Transporting Polypeptide 1B1 in Human Beings

2013 ◽  
Vol 113 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Victoria C. Ziesenitz ◽  
Sonja K. König ◽  
Nina Mahlke ◽  
Ricarda Jantos ◽  
Gisela Skopp ◽  
...  
Keyword(s):  
Organic Anion ◽  
Hepatic Uptake ◽  
Human Beings ◽  
Organic Anion Transporting Polypeptide

scholarly journals Evolutionary Analysis of OAT Gene Family in River and Swamp Buffalo: Potential Role of SLCO3A1 Gene in Milk Performance

Genes ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1394
Author(s):  
Xiaoya Ma ◽  
Shasha Liang ◽  
Aixin Liang ◽  
Hossam Eldin Rushdi ◽  
Tingxian Deng
Keyword(s):  
Candidate Genes ◽  
Potential Role ◽  
Organic Anion ◽  
Comparative Genomic ◽  
Evolutionary Analysis ◽  
River Buffalo ◽  
Anion Transporter ◽  
Milk Performance ◽  
Swamp Buffalo

The organic anion transporter (OAT) family is the subfamily of the solute carrier (SLC) superfamily, which plays a vital role in regulating essential nutrients in milk. However, little is known about the members’ identification, evolutionary basis, and function characteristics of OAT genes associated with milk performance in buffalo. Comparative genomic analyses were performed to identify the potential role of buffalo OAT genes in milk performance in this study. The results showed that a total of 10 and 7 OAT genes were identified in river buffalo and swamp buffalo, respectively. These sequences clustered into three groups based on their phylogenetic relationship and had similar motif patterns and gene structures in the same groups. Moreover, the river-specific expansions and homologous loss of OAT genes occurred in the two buffalo subspecies during the evolutionary process. Notably, the duplicated SLCO3A1 gene specific to river buffalo showed higher expression level in mammary gland tissue than that of swamp buffalo. These findings highlight some promising candidate genes that could be potentially utilized to accelerate the genetic progress in buffalo breeding programs. However, the identified candidate genes require further validation in a larger cohort for use in the genomic selection of buffalo for milk production.

Electroneutral uptake and electrogenic secretion of a fluorescent bile salt by rat hepatocyte couplets

1993 ◽  
Vol 264 (2) ◽  
pp. G220-G230 ◽  
Author(s):  
S. A. Weinman ◽  
J. Graf ◽  
C. Veith ◽  
J. L. Boyer
Keyword(s):  
Bile Salt ◽  
Time Course ◽  
Organic Anion ◽  
Hepatic Uptake ◽  
Membrane Voltage ◽  
Electrogenic Transport ◽  
Anion Secretion ◽  
Uptake Process ◽  
Transmembrane Potential Difference

The role of membrane voltage as a driving force for the hepatic uptake and secretion of fluorescent bile salts has been examined in isolated hepatocyte couplets. The present study demonstrates that the fluorescent bile salt derivative (N-[7-(nitrobenz-2-oxa- 1,3-diazol-4-yl)]-7-amino-3 alpha, 12 alpha-dihydroxy-5-cholan-24-oyl)-2-aminoethanesulfonate (7 beta-NBD-NCT) is taken up into hepatocytes by a saturable process with a Kt of 2.7 microM. Uptake rate was reduced by only 22% after total Na+ replacement and was independent of transmembrane potential difference over a range of -135 to +25 mV. In contrast, secretion into the canalicular space was strongly dependent on membrane voltage over the range from -34 to 0 mV in a manner consistent with electrodiffusion of an anion. Fitting the secretion time course to that predicted by electrodiffusion demonstrated that only approximately 50% of total secretion can result from electrodiffusion. Studies in isolated perfused liver confirmed this observation that depolarization caused a decrease in bile salt secretion rate. These results demonstrate that 7 beta-NBD-NCT is transported by a neutral uptake process at the sinusoidal membrane and is secreted across the canalicular membrane in part by electrogenic transport. This suggests that voltage changes could be a common pathway resulting in impaired organic anion secretion in diverse cholestatic syndromes.

Relationship between biliary lipid and protoporphyrin secretion; potential role of mdr2 P-glycoprotein in hepatobiliary organic anion transport

1996 ◽  
Vol 24 (3) ◽  
pp. 343-352 ◽  
Author(s):  
Gerard J.J. Beukeveld ◽  
Gerda In't Veld ◽  
Rick Havinga ◽  
Albert K. Groen ◽  
Bert G. Wolthers ◽  
...  
Keyword(s):  
Potential Role ◽  
Organic Anion ◽  
Anion Transport ◽  
Biliary Lipid ◽  
Organic Anion Transport ◽  
P Glycoprotein
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