scholarly journals Population pharmacokinetics of ciclosporin in Chinese children with aplastic anemia: effects of weight, renal function and stanozolol administration

2013 ◽  
Vol 34 (7) ◽  
pp. 969-975 ◽  
Author(s):  
Shao-qing Ni ◽  
Wei Zhao ◽  
Jue Wang ◽  
Su Zeng ◽  
Shu-qing Chen ◽  
...  
Keyword(s):  
Renal Function ◽  
Aplastic Anemia ◽  
Population Pharmacokinetics ◽  
Chinese Children

scholarly journals Population Pharmacokinetics and Pharmacodynamics of Levofloxacin in Acutely Hospitalized Older Patients with Various Degrees of Renal Function

2016 ◽  
Vol 61 (3) ◽  
Author(s):  
Pier Giorgio Cojutti ◽  
Virginia Ramos-Martin ◽  
Isabella Schiavon ◽  
Paolo Rossi ◽  
Massimo Baraldo ◽  
...  
Keyword(s):  
Renal Function ◽  
Clinical Outcome ◽  
Creatinine Clearance ◽  
Population Pharmacokinetics ◽  
Older Patients ◽  
Classification And Regression Tree ◽  
Therapeutic Drug ◽  
Time Curve ◽  
Content Type ◽  
Cart Analysis

ABSTRACT A retrospective study was conducted in a large sample of acutely hospitalized older patients who underwent therapeutic drug monitoring during levofloxacin treatment. The aim was to assess the population pharmacokinetics (popPK) and pharmacodynamics of levofloxacin among older patients. PopPK and Monte Carlo simulation were performed to define the permissible doses in older patients according to various degrees of renal function. Classification and regression tree (CART) analysis was used to detect the cutoff 24-hour area under the concentration-time curve (AUC24)/MIC ratio that best correlated with the clinical outcome. The probability of target attainment (PTA) of this value was calculated against different pathogens. A total of 168 patients were included, and 330 trough and 239 peak concentrations were used for the popPK analysis. Creatinine clearance (CrCL) was the only covariate that improved the model fit (levofloxacin CL = 0.399 + 0.051 × CrCLCKD-EPI [creatinine clearance estimated by means of the chronic kidney disease epidemiology]). Drug doses ranged between 500 mg every 48 h and 500 mg every 12 h in relation to different renal functions. The identified cutoff AUC24/MIC ratio (≥95.7) was the only covariate that correlated with a favorable clinical outcome in multivariate regression analysis (odds ratio [OR], 20.85; 95% confidence interval [CI], 1.56 to 186.73). PTAs were optimal (>80%) against Escherichia coli and Haemophilus influenzae, borderline against Staphylococcus aureus, and suboptimal against Pseudomonas aeruginosa. The levofloxacin doses defined in our study may be effective for the treatment of infections due to bacterial pathogens, with an MIC of ≤0.5 mg/liter in older patients with various degrees of renal function, while minimizing the toxicity risk. Conversely, the addition of another active antimicrobial should be considered whenever treating infections caused by less susceptible pathogens.

scholarly journals Population pharmacokinetics of valproate in Chinese children with epilepsy

2007 ◽  
Vol 28 (10) ◽  
pp. 1677-1684 ◽  
Author(s):  
De-chun JIANG ◽  
Li WANG ◽  
Yu-qin WANG ◽  
Lin LI ◽  
Wei LU ◽  
...  
Keyword(s):  
Population Pharmacokinetics ◽  
Chinese Children

scholarly journals Population pharmacokinetics modeling of levetiracetam in Chinese children with epilepsy

2012 ◽  
Vol 33 (6) ◽  
pp. 845-851 ◽  
Author(s):  
Ying-hui Wang ◽  
Li Wang ◽  
Wei Lu ◽  
De-wei Shang ◽  
Min-ji Wei ◽  
...  
Keyword(s):  
Population Pharmacokinetics ◽  
Chinese Children

Study on population pharmacokinetics of cyclosporine in children with aplastic anemia

2012 ◽  
Vol 12 (3) ◽  
pp. 212-216
Author(s):  
WenWen ZHANG ◽  
Hua ZHANG ◽  
Ling XUE ◽  
Rao DU ◽  
Cheng WANG ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Population Pharmacokinetics

scholarly journals Population pharmacokinetics of lamotrigine in Chinese children with epilepsy

2012 ◽  
Vol 33 (11) ◽  
pp. 1417-1423 ◽  
Author(s):  
Da-ke He ◽  
Li Wang ◽  
Jiong Qin ◽  
Shen Zhang ◽  
Wei Lu ◽  
...  
Keyword(s):  
Population Pharmacokinetics ◽  
Chinese Children

scholarly journals Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function

2022 ◽  
Vol Volume 15 ◽  
pp. 53-62
Author(s):  
Matthias Gijsen ◽  
Omar Elkayal ◽  
Pieter Annaert ◽  
Ruth Van Daele ◽  
Philippe Meersseman ◽  
...  
Keyword(s):  
Renal Function ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Target Attainment
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