scholarly journals The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts

2012 ◽  
Vol 33 (12) ◽  
pp. 1488-1494
Author(s):  
Qi Jin ◽  
Ning Zhang ◽  
Jian Zhou ◽  
Chang-jian Lin ◽  
Yang Pang ◽  
...  
1998 ◽  
Vol 31 ◽  
pp. 334 ◽  
Author(s):  
M. Yashima ◽  
S. Armin ◽  
Y.-H. Kim ◽  
T.-J. Wu ◽  
J.-M. Cao ◽  
...  

Heart Rhythm ◽  
2005 ◽  
Vol 2 (5) ◽  
pp. S161
Author(s):  
Mar Gonzalez Vasserot ◽  
Mariana Gnoatto ◽  
José L. Merino ◽  
Ignacio Fernández ◽  
Arcadio García-Alberola ◽  
...  

1991 ◽  
Vol 122 (5) ◽  
pp. 1355-1360 ◽  
Author(s):  
Werner Peters ◽  
Eli S. Gang ◽  
Hidetaka Okazaki ◽  
Simon Solingen ◽  
Yoshinori Kobayashi ◽  
...  

2003 ◽  
Vol 284 (1) ◽  
pp. H249-H255 ◽  
Author(s):  
Masaaki Yashima ◽  
Young-Hoon Kim ◽  
Sean Armin ◽  
Tsu-Juey Wu ◽  
Yasushi Miyauchi ◽  
...  

The probabilistic nature of the ventricular defibrillation threshold (DFT) remains poorly understood. We hypothesized that shock outcome is a function of the amount of myocardium in its vulnerable period (VP). The endocardial surface of five isolated, perfused swine right ventricles was mapped with 477 bipolar electrodes during ventricular fibrillation (VF). Shock parameters and VF cycle length were not significantly different in the successful (S; n = 26) and failed (F; n= 26) trials. At the instant of the shock, the number of sites with 45- to 55-ms recovery was significantly smaller in the S trials than the F trials ( P < 0.04). No significant difference in the number of sites with recovery intervals outside the 45- to 55-ms range was seen in S and F shocks. Endocardial action potential showed that a recovery time of 45–55 ms corresponded to the VP spanning −15 to −60 mV in 92% of the regenerative action potentials. We conclude that the probabilistic nature of the DFT is related to the amount of myocardium in its VP.


1994 ◽  
Vol 24 (4) ◽  
pp. 1069-1072 ◽  
Author(s):  
S.Adam Strickberger ◽  
John D. Hummel ◽  
Laura E. Horwood ◽  
John Jentzer ◽  
Emile Daoud ◽  
...  

2005 ◽  
Vol 28 (2) ◽  
pp. 97-101 ◽  
Author(s):  
MARIA I. ANASTASIOU-NANA ◽  
ELEFTHERIA P. TSAGALOU ◽  
CHRISTOS CHARITOS ◽  
KOSTANTINOS X. SIAFAKAS ◽  
STAVROS DRAKOS ◽  
...  

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