scholarly journals Anti-caries DNA vaccine-induced secretory immunoglobulin A antibodies inhibit formation of Streptococcus mutans biofilms in vitro

2012 ◽  
Vol 34 (2) ◽  
pp. 239-246 ◽  
Author(s):  
Li Huang ◽  
Qing-an Xu ◽  
Chang Liu ◽  
Ming-wen Fan ◽  
Yu-hong Li
Keyword(s):  
Streptococcus Mutans ◽  
Dna Vaccine ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Secretory Immunoglobulin

A comparative study of secretory immunoglobulin A and immunoglobulin G in host defense in an in vitro pneumonia model

2006 ◽  
Vol 191 (3) ◽  
pp. 386-390 ◽  
Author(s):  
Lawrence N. Diebel ◽  
David M. Liberati ◽  
Michael T. White ◽  
Clement A. Diglio ◽  
William J. Brown
Keyword(s):  
Comparative Study ◽  
Host Defense ◽  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Secretory Immunoglobulin A ◽  
Secretory Immunoglobulin

Interaction of secretory immunoglobulin A antibodies withNaegleria fowleritrophozoites and collagen type I

2003 ◽  
Vol 49 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Mineko Shibayama ◽  
José de Jesús Serrano-Luna ◽  
Saúl Rojas-Hernández ◽  
Rafael Campos-Rodríguez ◽  
Víctor Tsutsumi
Keyword(s):  
Collagen Type ◽  
Immunoglobulin A ◽  
Collagen Type I ◽  
Secretory Iga ◽  
Type I ◽  
Secretory Immunoglobulin A ◽  
Naegleria Fowleri ◽  
Nægleria Fowleri ◽  
Secretory Immunoglobulin

In this work, we analyzed the in vitro interaction of human secretory immunoglobulin A (sIgA) antibodies with Naegleria fowleri trophozoites and the capacity of these antibodies to inhibit amoeba adherence to collagen type I. We also studied N. fowleri antigens that are recognized by sIgA, using immunoblot assays. Immunocytochemical analysis of the interaction showed a redistribution of antigens on the surface of trophozoites by sIgA antibodies. Ultrastructural analysis of antibody–amoeba interaction showed that besides the patching and cap formation, parasites were capable of eliminating the antigen–antibody complex produced on the surface. sIgA antibodies were capable of inhibiting the in vitro adhesion of trophozoites to collagen type I. We suggest that nonsymptomatic infections by N. fowleri may stimulate a local specific immunity that prevents trophozoite adhesion and invasion of nasal mucosa.Key words: Naegleria fowleri, free-living amoebae, human antibodies, secretory IgA, mucosal immunity.

scholarly journals Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Secretory Immunoglobulin A Antibodies Reactive withStreptococcus mitis biovar 1, Streptococcus oralis, Streptococcus mutans, andEnterococcus faecalis during the First Two Years of Life

1999 ◽  
Vol 67 (4) ◽  
pp. 1878-1886 ◽  
Author(s):  
Michael F. Cole ◽  
Stacey Bryan ◽  
Mishell K. Evans ◽  
Cheryl L. Pearce ◽  
Michael J. Sheridan ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Immunoglobulin A ◽  
Oral Bacteria ◽  
Secretory Immunoglobulin A ◽  
Oral Streptococci ◽  
Human Infants ◽  
Whole Cells ◽  
Streptococcus Oralis ◽  
Salivary Secretory Immunoglobulin A ◽  
Secretory Immunoglobulin

ABSTRACT Secretory immunoglobulin A (SIgA) antibodies reactive with the pioneer oral streptococci Streptococcus mitis biovar 1 andStreptococcus oralis, the late oral colonizerStreptococcus mutans, and the pioneer enteric bacteriumEnterococcus faecalis in saliva samples from 10 human infants from birth to age 2 years were analyzed. Low levels of salivary SIgA1 and SIgA2 antibodies reactive with whole cells of all four species were detected within the first month after birth, even thoughS. mutans and E. faecalis were not recovered from the mouths of the infants during the study period. Although there was a fivefold increase in the concentration of SIgA between birth and age 2 years, there were no differences between the concentrations of SIgA1 and SIgA2 antibodies reactive with the four species over this time period. When the concentrations of SIgA1 and SIgA2 antibodies reactive with all four species were normalized to the concentrations of SIgA1 and SIgA2 in saliva, SIgA1 and SIgA2 antibodies reactive with these bacteria showed a significant decrease from birth to 2 years of age. Adsorption of each infant’s saliva with cells of one species produced a dramatic reduction of antibodies recognizing the other three species. Sequential adsorption of saliva samples removed all SIgA antibody to the bacteria, indicating that the SIgA antibodies were directed to antigens shared by all four species. The induction by the host of a limited immune response to common antigens that are likely not involved in adherence may be among the mechanisms that commensal streptococci employ to persist in the oral cavity.

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