scholarly journals Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry

2009 ◽  
Vol 30 (10) ◽  
pp. 1462-1470 ◽  
Author(s):  
Yu-qi He ◽  
Li Yang ◽  
Yong Liu ◽  
Jiang-wei Zhang ◽  
Jun Tang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Trap ◽  
Quadrupole Mass ◽  
Quadrupole Mass Spectrometry

scholarly journals Application of triple quadrupole mass spectrometry for the characterization of antibody–drug conjugates

2019 ◽  
Vol 411 (12) ◽  
pp. 2569-2576 ◽  
Author(s):  
Malin Källsten ◽  
Matthijs Pijnappel ◽  
Rafael Hartmann ◽  
Fredrik Lehmann ◽  
Lucia Kovac ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometry ◽  
Antibody Drug Conjugates ◽  
Quadrupole Mass Spectrometry ◽  
Drug Conjugates ◽  
Antibody Drug

Characterization of alkylacyl, alk-1-enylacyl and lyso subclasses of glycerophosphocholine by tandem quadrupole mass spectrometry with electrospray ionization

2003 ◽  
Vol 38 (7) ◽  
pp. 752-763 ◽  
Author(s):  
Fong-Fu Hsu ◽  
John Turk ◽  
Arun K. Thukkani ◽  
Maria C. Messner ◽  
Kristin R. Wildsmith ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Quadrupole Mass ◽  
Quadrupole Mass Spectrometry ◽  
Tandem Quadrupole

scholarly journals Pseudo-MS3Approach Using Electrospray Mass Spectrometry (ESI-MS/MS) to Characterize Certain (2E)-2-[3-(1H-Imidazol-1-yl)-1-phenylpropylidene]hydrazinecarboxamide Derivatives

2014 ◽  
Vol 2014 ◽  
pp. 1-10
Author(s):  
Ali S. Abdelhameed ◽  
Adnan A. Kadi ◽  
Mohamed I. Attia ◽  
Rihab F. Angawi ◽  
Mohamed W. Attwa ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Trap ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer ◽  
Fragmentation Mechanisms ◽  
Mass Spectrometer System ◽  
Spectrometer System ◽  
Fragmentation Processes ◽  
Unambiguous Assignment

An approach for the use of in-source fragmentation with electrospray ionization followed by product ion scan in a triple quadrupole mass spectrometer system is described. This approach is based on the elucidation of the various fragmentation pathways by further dissociation of each fragment ion in the ion spectrum. This can be achieved predominately, by combining fragmentor voltage induced dissociation (in-source fragmentation) with subsequent collision-induced dissociation; this process can be referred to as pseudo-MS3scan mode. This technique permitted unambiguous assignment and provided sufficient sensitivity and specificity. It is advantageous for structure elucidation of unknown compounds. We investigate the possibility of using in-source fragmentation with the diverse novel chemical entities encompassing different substituents. This process was intended to improve the qualitative capability of tandem mass spectrometry simulating the MS3of ion trap for studying fragmentation mechanisms. The approach is to implement the investigated technique as a well established tool for the characterization of new pharmacologically important chemical entities. The data presented in this paper provided useful information on the effect of different substituents on the ionization/fragmentation processes and can be used in the characterization of (2E)-2-[3-(1H-imidazol-1-yl)-1-phenylpropylidene]-hydrazinecarboxamide derivatives3a–h.

Sign in / Sign up

Export Citation Format

Share Document