scholarly journals Elevation of Fatty Acid-Binding Protein 4 Is Predisposed by Family History of Hypertension and Contributes to Blood Pressure Elevation

2012 ◽  
Vol 25 (10) ◽  
pp. 1124-1130 ◽  
Author(s):  
Hideki Ota ◽  
Masato Furuhashi ◽  
Shutaro Ishimura ◽  
Masayuki Koyama ◽  
Yusuke Okazaki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acid ◽  
Family History ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Blood Pressure Elevation ◽  
Acid Binding Protein ◽  
History Of ◽  
Family History Of Hypertension

scholarly journals Possitive correlation between adipocyte fatty acid-binding protein and epicardial fat in patients with a family history of cardiovascular disesase

2017 ◽  
Vol 161 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Eliska Sovova ◽  
Milan Sova ◽  
Jana Zapletalova ◽  
David Stejskal ◽  
Marketa Sovova ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Family History ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Epicardial Fat ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
History Of

scholarly journals The T 54 Allele of the Intestinal Fatty Acid-Binding Protein 2 Is Associated with a Parental History of Stroke1

2000 ◽  
Vol 85 (8) ◽  
pp. 2801-2804
Author(s):  
Martin Carlsson ◽  
Marju Orho-Melander ◽  
Jan Hedenbro ◽  
Peter Almgren ◽  
Leif C. Groop
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Parental History ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
History Of

Abstract 389: Elevation of Fatty Acid-Binding Protein 4 is Associated with Left Ventricular Hypertrophy and Diastolic Dysfunction in a General Population

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Tomohiro Mita ◽  
Masato Furuhashi ◽  
Satoshi Yuda ◽  
Atsuko Muranaka ◽  
Shutaro Ishimura ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Fatty Acid ◽  
General Population ◽  
Diastolic Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Left Ventricular ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function. From database of the Tanno-Sobetsu Study, a study with prospective population-based cohort design, all data from female subjects who were on no medication and underwent echocardiography in 2011 (n = 108) were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography. FABP4 level was positively correlated with age, body mass index (BMI), blood pressure, triglycerides, HOMA-R, left ventricular (LV) wall thickness (LVWT; r = 0.39, p < 0.01), and E/e’ (r = 0.32, p < 0.01), an index of impaired LV relaxation, and negatively correlated with the ratio of early diastolic to atrial systolic velocity (E/A) of transmitral flow (r = -0.30, p < 0.01). FABP4 concentration was not significantly correlated with LV ejection fraction or LV diastole diameter. Multiple regression analysis adjusted by age and blood pressure revealed that FABP4 concentration was independently correlated with LVWT and E/e’. However, FABP4 level was not selected as an independent determinant of LVWT or E/e’ when BMI and/or HOMA-R were additionally incorporated into the adjustment. In conclusion, FABP4 may contribute to LV hypertrophy and diastolic dysfunction via facilitation of obesity and insulin resistance in the general population.

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