scholarly journals Role of Intrauterine Chronic Hypoxia on Vascular Endothelial Function and Nitric Oxide Synthase Expression in the Aged Rats Offspring

2012 ◽  
Vol 25 (1) ◽  
pp. 133-133
Author(s):  
Z.-h. WANG ◽  
Z.-y. HUANG ◽  
G.-r. LU
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Function ◽  
Chronic Hypoxia ◽  
Vascular Endothelial ◽  
Aged Rats ◽  
Vascular Endothelial Function ◽  
Oxide Synthase

The effect of nitric oxide synthase 4ab gene polymorphism on vascular endothelial function in healthy subjects

2003 ◽  
Vol 12 (2) ◽  
pp. A55
Author(s):  
Bill Bilsborough ◽  
Daniel J. Green ◽  
Cyril D.S. Mamotte ◽  
Frank M. van Bockxmeer ◽  
Gerry O'Driscoll ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gene Polymorphism ◽  
Endothelial Function ◽  
Healthy Subjects ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Oxide Synthase

Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function

2003 ◽  
Vol 169 (1) ◽  
pp. 131-138 ◽  
Author(s):  
William Bilsborough ◽  
Daniel J. Green ◽  
Cyril D.S. Mamotte ◽  
Frank M. van Bockxmeer ◽  
Gerard J. O'Driscoll ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gene Polymorphism ◽  
Endothelial Function ◽  
Endothelial Nitric Oxide Synthase ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Pteridines ◽  
2013 ◽  
Vol 24 (1) ◽  
pp. 13-19
Author(s):  
Benno Cardini ◽  
Rupert Oberhuber ◽  
Sven R. Hein ◽  
Katrin Watschinger ◽  
Martin Hermann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pathological State ◽  
Vascular Endothelial ◽  
Oxide Synthase

AbstractIschemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin. Suboptimal concentrations of tetrahydrobiopterin result in a reduced biosynthesis of nitric oxide leading to vascular endothelial dysfunction. Tetrahydrobiopterin supplementation has been shown to protect from this pathological state in a plethora of cardiovascular diseases including transplant-related ischemia-reperfusion injury. Even though still controversially discussed, there is increasing evidence emerging from both human as well as animal studies that tetrahydrobiopterin-mediated actions rely on its nitric oxide synthase cofactor activity rather than on its antioxidative properties. Herein, we review the current literature regarding the role of tetrahydrobiopterin in ischemia-reperfusion injury including our experience acquired in a murine pancreas transplantation model.

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