scholarly journals The Natural History of Severe Acute Liver Injury

2017 ◽  
Vol 112 (9) ◽  
pp. 1389-1396 ◽  
Author(s):  
David G Koch ◽  
J L Speiser ◽  
V Durkalski ◽  
R J Fontana ◽  
T Davern ◽  
...  
Keyword(s):  
Liver Injury ◽  
Natural History ◽  
Acute Liver Injury ◽  
History Of

scholarly journals Natural history and predictors of poor outcomes in acute liver injury patients in a setting without liver transplant facility

2019 ◽  
Vol 2 (2) ◽  
pp. 6
Author(s):  
Alizeh Abbas
Keyword(s):  
Liver Injury ◽  
Natural History ◽  
Total Bilirubin ◽  
Acute Liver Injury ◽  
High Burden ◽  
Significant Burden ◽  
History Of ◽  
Causes Of Mortality ◽  
Poor Outcomes ◽  
Very High

Hepatitis is one of the leading causes of mortality globally and Pakistan, too, has a very high burden of liver disease and associated morbidity and mortality. Significant burden combined with lack of adequate transplant facilities make it crucial to understand predictors and natural history of more severe stages of liver damage or inflammation, such as acute liver injury, as is the aim of this study. Even though it is known that Acute Liver Injury (ALI) is defined as INR ≥ 2.0, ALT ≥ 10X ULN, and Total Bilirubin ≥ 3 mg/dl, there is a dearth of literature on factors and prognosis associated with ALI.

scholarly journals Bicalutamide-Associated Acute Liver Injury and Migratory Arthralgia: A Rare but Clinically Important Adverse Effect

2018 ◽  
Vol 12 (2) ◽  
pp. 266-270 ◽  
Author(s):  
Helga M. Gretarsdottir ◽  
Elin Bjornsdottir ◽  
Einar S. Bjornsson
Keyword(s):  
Prostate Cancer ◽  
Liver Injury ◽  
Causality Assessment ◽  
Acute Liver Injury ◽  
Assessment Method ◽  
Hepatitis Viruses ◽  
Drug Induced ◽  
History Of ◽  
Upper Abdomen ◽  
Liver Tests

We describe a case of acute liver injury and migratory arthralgia in a patient receiving bicalutamide treatment for prostate cancer. A 67-year-old male with metastatic prostate cancer presented with a 6-day history of migratory arthralgia. He had been undergoing treatment with bicalutamide for 4 months; 3 weeks prior to symptom appearance the bicalutamide dose had been increased. He had no other symptoms. Liver tests and inflammatory markers were markedly elevated. Serology for hepatitis viruses A, B, and C, CMV, and EBV and autoimmune causes were all negative, and an ultrasound of the upper abdomen was normal. There was no history of blood transfusion, intravenous drug abuse, or alcohol abuse. Due to the suspicion of a drug-induced symptomatology, bicalutamide was discontinued and the patient started on 30 mg prednisolone daily. Three weeks later he was symptom free and after 6 weeks his liver tests were almost normal. The Roussel Uclaf Causality Assessment Method (RUCAM) suggested a high probability of liver injury. Bicalutamide has very rarely been reported as a causative agent for liver injury and to our knowledge never for migratory polyarthralgia. The migratory polyarthralgia was attributed to bicalutamide due to the absence of other etiological factors and the disappearance of symptoms after discontinuation of the drug. To our knowledge, this is the first published case report of migratory arthralgia and concomitant liver injury attributed to bicalutamide.

Mo1426 – Natural History and Predictors of Poor Outcome Among Patients with Non-Acetaminophen Induced Acute Liver Injury

2019 ◽  
Vol 156 (6) ◽  
pp. S-1303-S-1304
Author(s):  
Ajeet Kumar ◽  
Shahab Abid ◽  
farheen Lubna ◽  
Maira M. Memon
Keyword(s):  
Liver Injury ◽  
Natural History ◽  
Acute Liver Injury ◽  
Poor Outcome

scholarly journals Acute liver injury and anorexia nervosa: a case report

2019 ◽  
Vol 13 (2) ◽  
pp. 128-131
Author(s):  
Simona Pascolini ◽  
Michele Cevolani ◽  
Federico Lari ◽  
Luigi Muratori ◽  
Marco Lenzi
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Liver Injury ◽  
Parenteral Nutrition ◽  
Nutritional Assessment ◽  
Acute Liver Injury ◽  
Transaminase Level ◽  
Progressive Increase ◽  
Psychiatric Institute ◽  
History Of

Anorexia nervosa is an eating disorder characterized by restriction of energy intake leading to a significant decrease in body weight. While it is primarily a psychiatric disorder, numerous medical complications can occur. In this article we describe a case of a 25-year-old woman with a 12-year history of severe restrictive anorexia nervosa that was referred to the Emergency Service of our Hospital, transferred from a psychiatric institute, for severe weight loss, dehydration, and progressive increase in transaminases. During the hospital stay she developed an acute liver injury with an increase in transaminase level up to 40× the ULN. Infective and immunological causes of acute hepatitis were excluded. In the suspect of severe starvation acute liver injury, we performed a nutritional assessment and started parenteral nutrition. After 15 days of parenteral nutrition, she gained 2.5 kg of body weight and liver tests were drastically reduced and nearly normal.

scholarly journals Diphenhydramine as a Cause of Drug-Induced Liver Injury

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Yunseok Namn ◽  
Yecheskel Schneider ◽  
Isabelle H. Cui ◽  
Arun Jesudian
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Chromosomal Translocation ◽  
Altered Mental Status ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Patient Reported ◽  
History Of ◽  
Concomitant Medications ◽  
Unites States

Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Unites States and accounts for 10% of acute hepatitis cases. We report the only known case of diphenhydramine-induced acute liver injury in the absence of concomitant medications. A 28-year-old man with history of 13/14-chromosomal translocation presented with fevers, vomiting, and jaundice. Aspartate-aminotransferase and alanine-aminotransferase levels peaked above 20,000 IU/L and 5,000 IU/L, respectively. He developed coagulopathy but without altered mental status. Patient reported taking up to 400 mg diphenhydramine nightly, without concomitant acetaminophen, for insomnia. He denied taking other medications, supplements, antibiotics, and herbals. A thorough workup of liver injury ruled out viral hepatitis (including A, B, C, and E), autoimmune, toxic, ischemic, and metabolic etiologies including Wilson’s disease. A liver biopsy was consistent with DILI without evidence of iron or copper deposition. Diphenhydramine was determined to be the likely culprit. This is the first reported case of diphenhydramine-induced liver injury without concomitant use of acetaminophen.

scholarly journals Rifampicin for Treatment of Cholestatic Pruritus Caused by Drug-Induced Acute Liver Injury as Assessed by the RUCAM Classification

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Ali R. Ahmadi ◽  
Maria Chicco ◽  
Marcel van den Berge
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Laboratory Testing ◽  
Acute Liver Injury ◽  
Anabolic Steroids ◽  
Black Market ◽  
Radiographic Imaging ◽  
Drug Induced ◽  
Liver And Kidney ◽  
History Of

A male bodybuilder of 39 years of age developed severe pruritus, nausea, and jaundice after injecting anabolic steroids purchased on the black market. The patient had no history of liver disease and no risk factors for viral hepatitis. Extensive laboratory testing, radiographic imaging, and liver biopsy excluded a majority of potential pathologies. The patient was diagnosed with drug-induced acute liver injury and secondary acute renal failure most likely caused by testosterone purchased on the black market. The pruritus caused insomnia and significant psychological distress. Treatment was initiated with cholestyramine and naltrexone for one week with no effect on the pruritus. Subsequently, all medications were stopped, and rifampicin was started. Pruritus resolved after starting rifampicin, and liver and kidney function improved rapidly and normalized within 5 months.

scholarly journals A natural history of efavirenz drug-induced liver injury

2021 ◽  
Vol 111 (12) ◽  
pp. 1190
Author(s):  
D Maughan ◽  
M Sonderup ◽  
N Gogela ◽  
M Locketz ◽  
H Wainwright ◽  
...  
Keyword(s):  
Liver Injury ◽  
Natural History ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
History Of

scholarly journals Adderall Induced Acute Liver Injury: A Rare Case and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Rohini R. Vanga ◽  
Bikram Bal ◽  
Kevin W. Olden
Keyword(s):  
Liver Injury ◽  
Rare Case ◽  
Acute Liver Injury ◽  
Past History ◽  
English Literature ◽  
Review Of The Literature ◽  
Intensive Monitoring ◽  
Hyperactivity Disorder ◽  
History Of ◽  
Time Of Presentation

Adderall (dextroamphetamine/amphetamine) is a widely prescribed medicine for the treatment of attention-deficit/hyperactivity disorder (ADHD) and is considered safe with due precautions. Use of prescribed Adderall without intention to overdose as a cause of acute liver injury is extremely rare, and to our knowledge no cases have been reported in the English literature. Amphetamine is an ingredient of recreational drugs such as Ecstacy and is known to cause hepatotoxicity. We describe here the case of a 55-year-old woman who developed acute liver failure during the treatment of ADHD with Adderall. She presented to the emergency room with worsening abdominal pain, malaise, and jaundice requiring hospitalization. She had a past history of partial hepatic resection secondary to metastasis from colon cancer which was under remission at the time of presentation. She recovered after intensive monitoring and conservative management. Adderall should be used carefully in individuals with underlying liver conditions.

Natural History and Predictors of Poor Outcome of Non-Acetaminophen Induced Severe Acute Liver Injury

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S1582
Author(s):  
Ajeet Kumar Lohana ◽  
Shahab Abid ◽  
Farheen Lubna Hashmi ◽  
Maira Mustafa
Keyword(s):  
Liver Injury ◽  
Natural History ◽  
Acute Liver Injury ◽  
Poor Outcome
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