Beneficial Effects of Statins on the Rates of Hepatic Fibrosis, Hepatic Decompensation, and Mortality in Chronic Liver Disease: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 112 (10) ◽  
pp. 1495-1505 ◽  
Author(s):  
Sehrish Kamal ◽  
Muhammad Ali Khan ◽  
Ankur Seth ◽  
George Cholankeril ◽  
Deepansh Gupta ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Hepatic Fibrosis ◽  
Meta Analysis ◽  
Chronic Liver ◽  
Hepatic Decompensation ◽  
Beneficial Effects

scholarly journals Use of anti-platelet agents in the prevention of hepatic fibrosis in patients at risk for chronic liver disease: a systematic review and meta-analysis

2018 ◽  
Vol 13 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Umair Iqbal ◽  
Brittany B. Dennis ◽  
Andrew A. Li ◽  
George Cholankeril ◽  
Donghee Kim ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Hepatic Fibrosis ◽  
Meta Analysis ◽  
Chronic Liver ◽  
Patients At Risk

Statins Decrease the Progression of Fibrosis, Decompensation of Cirrhosis and Mortality in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 152 (5) ◽  
pp. S906-S907
Author(s):  
Sehrish Kamal ◽  
Muhammad Ali Khan ◽  
Ankur Seth ◽  
Faisal Kamal ◽  
George Cholankeril ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Meta Analysis ◽  
Chronic Liver

scholarly journals Chronic Liver Disease in Ethiopia with a Particular Focus on the Etiological Spectrums: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Behailu Terefe Tesfaye ◽  
Temesgen Mulugeta Feyissa ◽  
Azmeraw Bekele Workneh ◽  
Esayas Kebede Gudina ◽  
Mengist Awoke Yizengaw
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
Meta Analysis ◽  
Chronic Liver ◽  
B Virus

Background. In Ethiopia, chronic liver disease (CLD) is the 7th leading cause of death, accounting for about 24 deaths per 100000 populations in 2019. Despite its burden, there is a lack of compiled pieces of evidence on CLD in the country. Thus, this systematic review and meta-analysis is intended to provide the pooled estimates of CLD etiologies and mortality rate in CLD patients in Ethiopia. Method. PubMed, Google Scholar, ScienceDirect, institutional repositories, national digital library, and the bibliography of the eligible articles information were the source of data for the present review. The keywords “hepatitis, chronic” [Mesh], “end-Stage Liver Disease” [Mesh], “chronic liver disease”, “liver cirrhosis” [Mesh], and “Ethiopia” were used for the searches. Overall, we retrieved 199 records and 12 were included in this review. We used the DerSimonian-Laird random-effects models to perform the meta-analysis. We conducted subgroup and meta-regression analyses to account for the heterogeneity of the estimates. Result. Hepatitis B virus, alcohol, and hepatitis C virus are the three most common etiologies of CLD in Ethiopia accounting for a pooled estimate of 40.0% [95% CI: 29.0, 51.0, I2 = 96.3, p < 0.001 ], 17.0% [95% CI: 9.0, 25.0, I2 = 96.7, p < 0.001 ], and 15.0% [95% CI: 9.0, 21.0, I2 = 95.8, p < 0.001 ], respectively. Unidentified etiology report has a substantial contribution accounting for an estimated pooled proportion of 45% [95% CI: 34.0, 56.0%, Q = 32.08, p < 0.001 , I2 = 87.53] of the CLD cases in the country. On the other hand, the overall hospital mortality rate in CLD patients is 25.0% [95% CI: 2.0, 47.0, I2 = 94.6, p < 0.001 ] in Ethiopia. Conclusion. Hepatitis B virus, hepatitis C virus, and alcohol are the three most common contributors to CLD cases in Ethiopia. The authors warrant routine screening and strengthening of preventive and treatment programs for viral hepatitis B and C, further enhancing the alcohol policy of the country.

scholarly journals Systematic Review and Meta-Analysis of the Relative Dose-Response Tests to Assess Vitamin A Status

2020 ◽  
Author(s):  
Jesse Sheftel ◽  
Sherry A Tanumihardjo
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Vitamin A ◽  
Chronic Liver Disease ◽  
Dose Response ◽  
Meta Analysis ◽  
Chronic Liver ◽  
Screening Tests ◽  
Demographic And Health Surveys ◽  
The Impact

ABSTRACT Vitamin A (VA) is an essential nutrient often lacking in the diets of people in developing countries. Accurate biomarkers of VA status are vital to inform public health policy and monitor interventions. The relative dose-response (RDR) and modified-RDR (MRDR) tests are semi-quantitative screening tests for VA deficiency that have been used in Demographic and Health Surveys and VA intervention studies. A systematic review and meta-analysis of sensitivity and specificity were conducted to summarize the physiological evidence to support the RDR tests as methods to assess VA status and investigate the impact of different pathological and physiological states on the tests. A total of 190 studies were screened for inclusion, with 21 studies comparing the RDR tests with the gold-standard biomarker, liver VA concentration (68% and 80% sensitivity and 85% and 69% specificity for the RDR and MRDR, respectively). Nearly all studies with VA interventions in VA-deficient populations demonstrated a response of the tests to VA intake that would be expected to improve VA status. The impacts of chronic liver disease, protein malnutrition, age, pregnancy and lactation, infection and inflammation, and various other conditions were examined in 51 studies. The RDR and MRDR tests were reported to have been used in 39 observational studies, and the MRDR has been used in at least 6 national micronutrient surveys. The RDR and MRDR are sensitive tests for determining population VA status and assessing VA interventions. Although they are robust to most physiological and pathological states, caution may be warranted when using the tests in neonates, individuals with chronic liver disease, and those with protein or iron malnutrition. Research on further improvements to the tests to increase accessibility, such as sampling breast milk instead of blood or using intramuscular doses in subjects with malabsorption, will allow wider adoption. This review was registered with PROSPERO as CRD42019124180.

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