Narrow Band Imaging, Magnifying Chromoendoscopy, and Gross Morphological Features for the Optical Diagnosis of T1 Colorectal Cancer and Deep Submucosal Invasion: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 112 (1) ◽  
pp. 54-64 ◽  
Author(s):  
Y Backes ◽  
A Moss ◽  
J B Reitsma ◽  
P D Siersema ◽  
L M G Moons
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Meta Analysis ◽  
Morphological Features ◽  
Submucosal Invasion ◽  
Optical Diagnosis ◽  
T1 Colorectal Cancer ◽  
Magnifying Chromoendoscopy

Multicentre prospective evaluation of real-time optical diagnosis of T1 colorectal cancer in large non-pedunculated colorectal polyps using narrow band imaging (the OPTICAL study)

Gut ◽  
2018 ◽  
Vol 68 (2) ◽  
pp. 271-279 ◽  
Author(s):  
Yara Backes ◽  
Matthijs P Schwartz ◽  
Frank ter Borg ◽  
Frank H J Wolfhagen ◽  
John N Groen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Score ◽  
White Light ◽  
Clinical Decision Making ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Colorectal Polyps ◽  
Optical Diagnosis ◽  
Temporal Validation ◽  
T1 Colorectal Cancer

ObjectiveThis study evaluated the preresection accuracy of optical diagnosis of T1 colorectal cancer (CRC) in large non-pedunculated colorectal polyps (LNPCPs).DesignIn this multicentre prospective study, endoscopists predicted the histology during colonoscopy in consecutive patients with LNPCPs using a standardised procedure for optical assessment. The presence of morphological features assessed with white light, and vascular and surface pattern with narrow-band imaging (NBI) were recorded, together with the optical diagnosis, the confidence level of prediction and the recommended treatment. A risk score chart was developed and validated using a multivariable mixed effects binary logistic least absolute shrinkage and selection (LASSO) model.ResultsAmong 343 LNPCPs, 47 cancers were found (36 T1 CRCs and 11 ≥T2 CRCs), of which 11 T1 CRCs were superficial invasive T1 CRCs (23.4% of all malignant polyps). Sensitivity and specificity for optical diagnosis of T1 CRC were 78.7% (95% CI 64.3 to 89.3) and 94.2% (95% CI 90.9 to 96.6), and 63.3% (95% CI 43.9 to 80.1) and 99.0% (95% CI 97.1 to 100.0) for optical diagnosis of endoscopically unresectable lesions (ie, ≥T1 CRC with deep invasion), respectively. A LASSO-derived model using white light and NBI features discriminated T1 CRCs from non-invasive polyps with a cross-validation area under the curve (AUC) of 0.85 (95% CI 0.80 to 0.90). This model was validated in a temporal validation set of 100 LNPCPs (AUC of 0.81; 95% CI 0.66 to 0.96).ConclusionOur study provides insights in the preresection accuracy of optical diagnosis of T1 CRC. Sensitivity is still limited, so further studies will show how the risk score chart could be improved and finally used for clinical decision making with regard to the type of endoresection to be used and whether to proceed to surgery instead of endoscopy.Trial registration numberNTR5561.

scholarly journals Surveillance in inflammatory bowel disease: is chromoendoscopy the only way to go? A systematic review and meta-analysis of randomized clinical trials

2020 ◽  
Vol 08 (05) ◽  
pp. E578-E590
Author(s):  
Ricardo Hannum Resende ◽  
Igor Braga Ribeiro ◽  
Diogo Turiani Hourneaux de Moura ◽  
Facundo Galetti ◽  
Rodrigo Silva de Paula Rocha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Meta Analysis ◽  
Mean Difference ◽  
Procedure Time ◽  
High Definition ◽  
Number Of Patients

Abstract Background and study aims Ulcerative colitis (UC) and Crohn’s disease (CD) have higher risk of colorectal cancer (CRC). Guidelines recommend dysplasia surveillance with dye-spraying chromoendoscopy (DCE). The aim of this systematic review and meta-analysis was to review all randomized clinical trials (RCTs) available and compare the efficacy of different endoscopic methods of surveillance for dysplasia in patients with UC and CD. Methods Databases searched were Medline, EMBASE, Cochrane and SCIELO/LILACS. It was estimated the risk difference (RD) for dichotomous outcomes (number of patients diagnosed with one or more dysplastic lesions, total number of dysplastic lesions diagnosed and number of dysplastic lesions detected by targeted biopsies) and mean difference for continuous outcomes (procedure time). Results This study included 17 RCTs totaling 2,457 patients. There was superiority of DCE when compared to standard-definiton white light endoscopy (SD-WLE). When compared with high-definition (HD) WLE, no difference was observed in all outcomes (number of patients with dysplasia (RD 0.06; 95 % CI [–0.01, 0.13])). Comparing other techniques, no difference was observed between DCE and virtual chromoendoscopy (VCE – including narrow-band imaging [NBI], i-SCAN and flexible spectral imaging color enhancement), in all outcomes except procedure time (mean difference, 6.33 min; 95 % CI, 1.29, 11.33). DCE required a significantly longer procedure time compared with WLE (mean difference, 7.81 min; 95 % CI, 2.76, 12.86). Conclusions We found that dye-spraying chromoendoscopy detected more patients and dysplastic lesions than SD-WLE. Although no difference was observed between DCE and HD-WLE or narrow-band imaging, the main outcomes favored numerically dye-spraying chromoendoscopy, except procedure time. Regarding i-SCAN, FICE and auto-fluorescence imaging, there is still not enough evidence to support or not their recommendation.

Narrow band imaging in head and neck unknown primary carcinoma: A systematic review and meta‐analysis

2019 ◽  
Vol 130 (7) ◽  
pp. 1692-1700 ◽  
Author(s):  
Pasquale Di Maio ◽  
Oreste Iocca ◽  
Armando Virgilio ◽  
Marco Giudice ◽  
Raul Pellini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Meta Analysis ◽  
Primary Carcinoma ◽  
Unknown Primary ◽  
Unknown Primary Carcinoma

Long-term Outcomes of Primary Endoscopic Resection vs Surgery for T1 Colorectal Cancer: A Systematic Review and Meta-analysis

2020 ◽  
Vol 18 (12) ◽  
pp. 2813-2823.e5 ◽  
Author(s):  
Jen-Hao Yeh ◽  
Cheng-Hao Tseng ◽  
Ru-Yi Huang ◽  
Chih-Wen Lin ◽  
Ching-Tai Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Endoscopic Resection ◽  
Meta Analysis ◽  
Long Term Outcomes ◽  
T1 Colorectal Cancer
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