Statins Associated With Decreased Risk of New Onset Inflammatory Bowel Disease

2016 ◽  
Vol 111 (10) ◽  
pp. 1416-1423 ◽  
Author(s):  
Ryan Ungaro ◽  
Helena L Chang ◽  
Justin Cote-Daigneaut ◽  
Saurabh Mehandru ◽  
Ashish Atreja ◽  
...  
1994 ◽  
Vol 24 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Patrick M. Burke ◽  
Deborah Neigut ◽  
Samuel Kocoshis ◽  
Jennifer Sauer ◽  
R. Chandra

2017 ◽  
Vol 31 (8) ◽  
pp. e363-e365 ◽  
Author(s):  
A. Egeberg ◽  
N. Wienholtz ◽  
G.H. Gislason ◽  
L. Skov ◽  
J.P. Thyssen

Gut ◽  
2019 ◽  
Vol 68 (9) ◽  
pp. 1597-1605 ◽  
Author(s):  
Simone N Vigod ◽  
Paul Kurdyak ◽  
Hilary K Brown ◽  
Geoffrey C Nguyen ◽  
Laura E Targownik ◽  
...  

ObjectivePatients with inflammatory bowel disease (IBD) have an elevated risk of mental illness. We determined the incidence and correlates of new-onset mental illness associated with IBD during pregnancy and post partum.DesignThis cohort study using population-based health administrative data included all women with a singleton live birth in Ontario, Canada (2002–2014). The incidence of new-onset mental illness from conception to 1-year post partum was compared between 3721 women with and 798 908 without IBD, generating adjusted HRs (aHR). Logistic regression was used to identify correlates of new-onset mental illness in the IBD group.ResultsAbout 22.7% of women with IBD had new-onset mental illness versus 20.4% without, corresponding to incidence rates of 150.2 and 132.8 per 1000 patient-years (aHR 1.12, 95% CI 1.05 to 1.20), or one extra case of new-onset mental illness per 43 pregnant women with IBD. The risk was elevated in the post partum (aHR 1.20, 95% CI 1.09 to 1.31), but not during pregnancy, and for Crohn’s disease (aHR 1.12, 95% CI 1.02 to 1.23), but not ulcerative colitis. The risk was specifically elevated for a new-onset mood or anxiety disorder (aHR 1.14, 95% CI 1.04 to 1.26) and alcohol or substance use disorders (aHR 2.73, 95% CI 1.42 to 5.26). Predictors of a mental illness diagnosis were maternal age, delivery year, medical comorbidity, number of prenatal visits, family physician obstetrical care and infant mortality.ConclusionWomen with IBD were at an increased risk of new-onset psychiatric diagnosis in the postpartum period, but not during pregnancy. Providers should look to increase opportunities for prevention, early identification and treatment accordingly.


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