scholarly journals Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis

2016 ◽  
Vol 111 (3) ◽  
pp. 355-365 ◽  
Author(s):  
Jun Pan ◽  
Lei Xin ◽  
Yi-Fei Ma ◽  
Liang-Hao Hu ◽  
Zhao-Shen Li
Keyword(s):  
Colorectal Cancer ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence

scholarly journals Colonoscopic screening is associated with reduced Colorectal Cancer incidence and mortality: a systematic review and meta-analysis

2020 ◽  
Vol 11 (20) ◽  
pp. 5953-5970
Author(s):  
Jiaxin Zhang ◽  
Guang Chen ◽  
Zhiguo Li ◽  
Peng Zhang ◽  
Xiaoke Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence

scholarly journals Efficacy and safety of chemopreventive agents on colorectal cancer incidence and mortality: systematic review and network meta-analysis

2018 ◽  
Vol Volume 10 ◽  
pp. 1433-1445 ◽  
Author(s):  
Sajesh K Veettil ◽  
Peerawat Jinatongthai ◽  
Surakit Nathisuwan ◽  
Nattawat Teerawattanapong ◽  
Siew Mooi Ching ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Chemopreventive Agents ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence

scholarly journals Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e032773 ◽  
Author(s):  
Henriette C Jodal ◽  
Lise M Helsingen ◽  
Joseph C Anderson ◽  
Lyubov Lytvyn ◽  
Per Olav Vandvik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Screening ◽  
Cancer Incidence ◽  
Cancer Mortality ◽  
Meta Analysis ◽  
Randomised Trials ◽  
Incidence And Mortality ◽  
Colorectal Cancer Incidence ◽  
Colorectal Cancer Mortality

ObjectiveEvaluate effectiveness, harms and burdens of faecal blood testing, sigmoidoscopy and colonoscopy screening for colorectal cancer over 15 years.DesignWe performed an update of a Cochrane systematic review, and performed network meta-analysis comparing randomised trials evaluating colorectal cancer screening with guaiac faecal occult blood test (gFOBT) (annual, biennial), faecal immunochemical test (FIT) (annual, biennial), sigmoidoscopy (once-only) or colonoscopy (once-only) in a healthy population, aged 50–79 years. We conducted subgroup analysis on sex. Follow-up >5 years was required for analysis of colorectal cancer incidence and mortality.Results12 randomised trials proved eligible. Compared with no-screening, we found high certainty evidence for sigmoidoscopy screening slightly reducing colorectal cancer incidence (relative risk (RR) 0.76; 95% confidence interval (CI 0.70 to 0.83) and mortality (RR 0.74; 95% CI 0.69 to 0.80), while gFOBT screening had little or no difference on colorectal cancer incidence, but slightly reduced colorectal cancer mortality (annual: RR 0.69; 95% CI 0.56 to 0.86, biennial: RR 0.88; 95% CI 0.82 to 0.93). No screening test reduced mortality nor incidence by more than six per 1000 screened over 15 years. Sigmoidoscopy had a greater effect in men, for both colorectal cancer incidence (women: RR 0.86; 95% CI 0.81 to 0.92, men: RR 0.75, 95% CI 0.71 to 0.79), and mortality (women: RR 0.85; 95% CI 0.71 to 0.96, men: RR 0.67; 95% CI 0.61 to 0.75) (moderate certainty).ConclusionsIn a 15-year perspective, sigmoidoscopy reduces colorectal cancer incidence, while sigmoidoscopy, annual and biennial gFOBT all reduce colorectal cancer mortality. Sigmoidoscopy may reduce colorectal cancer incidence and mortality more in men than in women.PROSPERO registration numberCRD42018093401.

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