Poor Outcomes in Hospitalized Patients With Gastrointestinal Bleeding: Impact of Baseline Risk, Bleeding Severity, and Process of Care

2014 ◽  
Vol 109 (10) ◽  
pp. 1603-1612 ◽  
Author(s):  
Vipul Jairath ◽  
J Thompson ◽  
B C Kahan ◽  
R Daniel ◽  
S A Hearnshaw ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Masood Faghih Dinevari ◽  
Mohammad Hossein Somi ◽  
Elham Sadeghi Majd ◽  
Mahdieh Abbasalizad Farhangi ◽  
Zeinab Nikniaz

Abstract Background There are limited number of studies with controversial findings regarding the association between anemia at admission and coronavirus disease 2019 (COVID-19) outcomes. Therefore, in this research, we aimed to investigate the prospective association between anemia and COVID-19 outcomes in hospitalized patients in Iran. Methods In this prospective study, the data of 1274 consecutive patients hospitalized due to COVID-19 were statistically analyzed. All biomarkers, including hemoglobin and high-sensitivity C-reactive protein (hs-CRP) levels were measured using standard methods. Anemia was defined as a hemoglobin (Hb) concentration of less than 13 g/dL and 12 g/dL in males and females, respectively. Assessing the association between anemia and COVID-19 survival in hospitalized patients was our primary endpoint. Results The mean age of the participants was 64.43 ± 17.16 years, out of whom 615 (48.27%) were anemic subjects. Patients with anemia were significantly older (P = 0.02) and had a higher frequency of cardiovascular diseases, hypertension, kidney disease, diabetes, and cancer (P < 0.05). The frequency of death (anemic: 23.9% vs. nonanemic: 13.8%), ICU admission (anemic: 27.8% vs. nonanemic:14.71%), and ventilator requirement (anemic: 35.93% vs. nonanemic: 20.63%) were significantly higher in anemic patients than in nonanemic patients (P < 0.001). According to the results of regression analysis, after adjusting for significant covariate in the univariable model, anemia was independently associated with mortality (OR: 1.68, 95% CI: 1.10, 2.57, P = 0.01), ventilator requirement (OR: 1.74, 95% CI: 1.19, 2.54, P = 0.004), and the risk of ICU admission (OR: 2.06, 95% CI: 1.46, 2.90, P < 0.001). Conclusion The prevalence of anemia in hospitalized patients with COVID-19 was high and was associated with poor outcomes of COVID-19.


2021 ◽  
Vol 93 (6) ◽  
pp. AB29-AB30
Author(s):  
Christopher Nguyen ◽  
Alexander Dang ◽  
Michelle Baliss ◽  
Mohammad Bilal ◽  
Ronak Gandhi ◽  
...  

Author(s):  
Sameer D. Saini ◽  
Akbar K. Waljee

This chapter guides the reader on the general principles, clinical manifestations, and management of acute gastrointestinal bleeding in hospitalized patients.


2020 ◽  
Vol 91 (6) ◽  
pp. AB590-AB591
Author(s):  
Thomas Mules ◽  
Catherine A. Stedman ◽  
Steven Ding ◽  
Michael Burt ◽  
Richard Gearry ◽  
...  

2014 ◽  
Vol 80 (7) ◽  
pp. 669-674 ◽  
Author(s):  
Joseph J. Weber ◽  
Swapnil D. Kachare ◽  
Nasreen A. Vohra ◽  
Timothy F. Fitzgerald ◽  
Jan H. Wong

Mortality from breast cancer in eastern North Carolina (ENC) surpasses the rest of North Carolina (RNC). We sought to identify modifiable factors associated with the increased mortality of women diagnosed with breast cancer in ENC. A retrospective cohort study of women diagnosed with breast cancer in North Carolina between January 1, 2004, and December 31, 2007 (n = 27,631) was studied. There was no difference in the pathologic T ( P = 0.62), N ( P = 0.26), or stage grouping ( P = 0.25) at diagnosis. Women in ENC were less likely to be white ( P < 0.001), estrogen receptor (ER)-positive ( P < 0.001), progesterone receptor (PR)-positive ( P < 0.001), or to receive adjuvant chemotherapy ( P = 0.02). The median survival of ENC patients was worse than RNC patients (39 vs. 43 months, P = 0.003). Improved median survival was associated with ER status ( P < 0.001), PR status ( P < 0.001), race/ethnicity ( P < 0.001), and delivery of timely chemotherapy ( P < 0.0001). ER-negative status ( P = 0.01), black race ( P = 0.03), and adjuvant chemotherapy within 90 days of surgery ( P < 0.001) remained significant predictors of survival. The poor outcomes observed in ENC can be attributed to recognized prognostic primary patient and tumor characteristics. However, a failure in process of care remains significantly associated with poorer outcomes. Improved timing of delivery of chemotherapy could affect breast cancer mortality.


2019 ◽  
Vol 113 (3) ◽  
pp. 117-123
Author(s):  
Elizabeth De Francesco Daher ◽  
Douglas de Sousa Soares ◽  
Gabriela Studart Galdino ◽  
Ênio Simas Macedo ◽  
Pedro Eduardo Andrade de Carvalho Gomes ◽  
...  

2011 ◽  
Vol 33 (11) ◽  
pp. 1225-1233 ◽  
Author(s):  
A. Lanas ◽  
L. Aabakken ◽  
J. Fonseca ◽  
Z. A. Mungan ◽  
G. V. Papatheodoridis ◽  
...  

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