A Comparative Study of Sequential Therapy and Standard Triple Therapy for Helicobacter pylori Infection: A Randomized Multicenter Trial

2014 ◽  
Vol 109 (4) ◽  
pp. 535-541 ◽  
Author(s):  
Liya Zhou ◽  
Jianzhong Zhang ◽  
Minhu Chen ◽  
Xiaohua Hou ◽  
Zhaoshen Li ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Comparative Study ◽  
Triple Therapy ◽  
Sequential Therapy ◽  
Multicenter Trial ◽  
Helicobacter Pylori Infection ◽  
Standard Triple Therapy

Sequential Therapy or Standard Triple Therapy for Helicobacter pylori Infection

2016 ◽  
Vol 23 (3) ◽  
pp. e880-e893 ◽  
Author(s):  
Li Feng ◽  
Mao-Yao Wen ◽  
Yong-Jun Zhu ◽  
Ruo-Ting Men ◽  
Li Yang
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Sequential Therapy ◽  
Helicobacter Pylori Infection ◽  
Standard Triple Therapy

scholarly journals Efficacy of sequential therapy versus standard triple therapy versus quinolone-based triple therapy for eradication of Helicobacter pylori infection

2019 ◽  
Vol 6 (6) ◽  
pp. 1898
Author(s):  
Rishabh Sehgal ◽  
Harsimranjit Singh ◽  
Inderpal Singh ◽  
Jyotisterna Mittal ◽  
Kanwerpreet Kaur
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Therapy Group ◽  
Sequential Therapy ◽  
Helicobacter Pylori Infection ◽  
P Value ◽  
Standard Triple Therapy ◽  
Wide Range ◽  
Urease Test ◽  
Significant Difference

Background: Helicobacter pylori colonization is a risk factor for Adenocarcinomas of the distal (noncardia) stomach. The presence of Helicobacter pylori is strongly associated with primary gastric lymphoma. The urea breath test, the stool antigen test, and biopsy-based tests can all be used to assess the success of treatment. Helicobacter pylori is susceptible to a wide range of antibiotics in vitro, monotherapy is not usually successful, probably because of inadequate antibiotic delivery to the colonization niche. Current regimens consist of a PPI or H2 blocker, bismuth citrate and two or three antimicrobial agents given for 7-14 days. Research on optimizing drug combinations to increase efficacy continues. Efficacy of Sequential Therapy versus Standard Triple Therapy versus Quinolone-based Triple Therapy for eradication of Helicobacter pylori infection is done in this study.Methods: This study had been conducted on 150 patients divided into three groups randomly 50 Patients each and were treated with Sequential, Standard and Quinolone based triple therapy respectively. Patients were followed up no sooner than four weeks of completing therapy by rapid urease test to confirm eradication.Results: There was no significant difference with regards to presence of GERD, Gastric Ulcers, Duodenal Ulcers (p value>0.05) except for presence of erosive gastritis which was significantly higher in patients in quinolone group (p value<0.05). The eradication rate was 90%, 86%, 82% in Sequential therapy group, Triple therapy group and Fluroquinolone group respectively. However, there was no statistically significant difference in eradication rates in these groups (p value>0.05).Conclusions: Sequential therapy group had better eradication rates (90%) as compared to standard triple therapy group (86%) and fluroquinolone therapy group (82%) but results were not statistically significant when all three groups were compared together.

Ten and Eight-day Sequential Therapy in Comparison to Standard Triple Therapy for Eradicating Helicobacter pylori Infection

2010 ◽  
Vol 44 (4) ◽  
pp. 261-266 ◽  
Author(s):  
Omero Alessandro Paoluzi ◽  
Emanuela Visconti ◽  
Fabio Andrei ◽  
Claudio Tosti ◽  
Raffaella Lionetti ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Sequential Therapy ◽  
Helicobacter Pylori Infection ◽  
Standard Triple Therapy
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