Abnormal Structure and Function of the Esophagogastric Junction and Proximal Stomach in Gastroesophageal Reflux Disease

2014 ◽  
Vol 109 (5) ◽  
pp. 658-667 ◽  
Author(s):  
Jelena Curcic ◽  
Shammodip Roy ◽  
Alexandra Schwizer ◽  
Elad Kaufman ◽  
Zsofia Forras-Kaufman ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Esophagogastric Junction ◽  
Structure And Function ◽  
Proximal Stomach ◽  
Abnormal Structure ◽  
And Function

scholarly journals Diagnosis and Etiological Analysis of Gastroesophageal Reflux Disease by Gastric Filling Ultrasound and GerdQ Scale

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Bo Wang ◽  
Qian Sun ◽  
Yonghong Du ◽  
Kexiao Mu ◽  
Jingxia Jiao
Keyword(s):  
Gastroesophageal Reflux ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Structure And Function ◽  
Youden Index ◽  
Abnormal Structure ◽  
And Function ◽  
Antireflux Barrier ◽  
Ultrasound Parameters

Objective. To investigate the diagnosis and etiological analysis of GERD by gastric filling ultrasound and GerdQ scale. Methods. The clinical data of 100 suspected GERD patients were selected for retrospective analysis. The selection time was from June 2016 to June 2019. According to the gold standard (endoscopy) results, they were divided into the gastroesophageal reflux group (positive, n = 62) and the nongastroesophageal reflux group (negative, n = 38); both gastric filling ultrasound and GerdQ scale examination were performed to compare the positive predictive value and negative predictive value, evaluate the abdominal esophageal length, His angle, and GerdQ scale score, and analyze the AUC value, sensitivity, specificity, and Youden index of His angle, length of abdominal esophagus, combined ultrasound parameters, and GerdQ scale in the diagnosis of GERD. Results. 100 patients with suspected GERD were diagnosed as GERD by endoscopy; in a total of 62 cases, the percentage was 62.00%. Among them, 28 cases were caused by the abnormal structure and function of the antireflux barrier, accounting for 45.16%, 18 cases were caused by the reduction of acid clearance of the esophagus, accounting for 29.03%, and 16 cases were caused by the weakening of the esophageal mucosal barrier, accounting for 25.81%. After ultrasound detection, the positive predictive value was 88.71% and the negative predictive value was 81.58%; after the GerdQ scale was tested, the positive predictive value was 71.43% and the negative predictive value was 54.05%. The length of the abdominal esophagus in the gastroesophageal reflux group was lower than that of the nongastroesophageal reflux group, while the scores of His angle and GerdQ scale were higher than those in the gastroesophageal reflux group ( P < 0.05 ). ROC curve analysis showed that the AUC values of His angle, length of abdominal esophagus, combined ultrasound parameters, and GerdQ scale to diagnose GERD were 0.957, 0.861, 0.996, and 0.931 ( P < 0.05 ), their sensitivity was 93.5%, 98.40%, 98.40%, and 90.30%, and the specificity was 92.10%, 63.20%, 100.00%, and 92.10%, respectively. Conclusion. Both gastric filling ultrasound and GerdQ scale have a certain application value in the diagnosis of GERD, but the former has a higher accuracy rate, and it is more common for gastroesophageal reflux caused by abnormal structure and function of antireflux barrier in etiological analysis.

Diminished Retention of Food in the Proximal Stomach Correlates with Increased Acidic Reflux in Patients with Gastroesophageal Reflux Disease and Dyspeptic Symptoms

2004 ◽  
Vol 49 (5) ◽  
pp. 750-756 ◽  
Author(s):  
José Ruver L. Herculano, Jr. ◽  
Luiz E. A. Troncon ◽  
Lilian R. O. Aprile ◽  
Eder R. Moraes ◽  
Marie Secaf ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Proximal Stomach ◽  
Dyspeptic Symptoms

Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux disease

2008 ◽  
Vol 120 (11-12) ◽  
pp. 350-359 ◽  
Author(s):  
Claudia Ringhofer ◽  
Johannes Lenglinger ◽  
Barbara Izay ◽  
Katharina Kolarik ◽  
Johannes Zacherl ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Esophagogastric Junction

Videoendoscopy and histopathology of the esophagogastric junction in patients with gastroesophageal reflux disease

2007 ◽  
Vol 119 (9-10) ◽  
pp. 283-290 ◽  
Author(s):  
Claudia Ringhofer ◽  
Johannes Lenglinger ◽  
Margit Eisler ◽  
Fritz Wrba ◽  
Roland Sedivy ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Esophagogastric Junction

scholarly journals Patterns of esophageal acidification and impairment of esophageal motility in gastroesophageal reflux disease and Barrett's esophagus

2020 ◽  
Author(s):  
Igor Maev ◽  
Elena Barkalova ◽  
Yuri Kucheryavyy ◽  
Maria Ovsepyan ◽  
Dmitrii Andreev ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Barrett’S Esophagus ◽  
Reflux Disease ◽  
Esophageal Motility ◽  
Barrett's Esophagus ◽  
Control Group ◽  
Control Subjects ◽  
And Function ◽  
And Control

Background: Gastroesophageal reflux disease (GERD) has a high prevalence worldwide and plays a major role in the development of Barrett's esophagus (BЕ) and esophageal adenocarcinoma. Aims: To evaluate the patterns of esophageal acidification and esophageal motility in patients with BЕ in comparison with various GERD phenotypes and control subjects. Materials and methods: 100 patients were examined: 31 patients with nonerosive reflux disease (NERD), 20 patients with erosive reflux disease (ERD), 17 patients with BE, 32 healthy individuals who made up the control group. All patients underwent 24-hours pH-impedance and high-resolution esophageal manometry. Results: According to the 24-hour pH-impedanсe, the total time with pH 4 in the esophagus was 1,9% in control patients, 11.6% in the NERD group, 19.35 in the ERD group and 28% in patients with BE. The average number of acid refluxes was 18.0 in the control group, 58.0 in the group with NERD, 78. in the group with ERD and 89.0 in patients with BE. The number of acidic refluxes was significantly correlated with the time on the acidification of the esophagus (r = 0.5439; p0.05). The analysis of the mean nocturnal baseline impedance (MNBI) revealed a tendency to decrease the values in patients with GERD relative to the control subjects, and there was a decrease in the values of MNBI as the severity of GERD from NERD to ERD and BE (p0.05). Manometric signs of hiatal hernia and/or hypotension of the lower esophageal sphincter were more often registered in the groups of patients with ERD (70%) and BE (65%) than in patients with NERD (32%) and in control group (12%). Conclusions: Increase in level of total time with pH 4, number of acid refluxes, reduced values of MNBI, as well as disorders of the structure and function of the esophagogastric junction and motility of the esophagus are associated with the severity of esophagus diseases.

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