Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study

2014 ◽  
Vol 109 (9) ◽  
pp. 1417-1423 ◽  
Author(s):  
Virendra Singh ◽  
Arun K Sharma ◽  
Lakshmi R Narasimhan ◽  
Ashish Bhalla ◽  
Navneet Sharma ◽  
...  
Keyword(s):  
Pilot Study ◽  
Alcoholic Hepatitis ◽  
Hepatitis A ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Severe Alcoholic Hepatitis ◽  
Stimulating Factor

Insights into the Role of Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis

2021 ◽  
Author(s):  
Chandan Kumar Kedarisetty ◽  
Anupam Kumar ◽  
Shiv Kumar Sarin
Keyword(s):  
Alcoholic Hepatitis ◽  
Severe Disease ◽  
Unmet Need ◽  
Standard Of Care ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Term Survival ◽  
Dose Monitoring ◽  
Severe Alcoholic Hepatitis ◽  
Stimulating Factor

AbstractAlcohol use disorder is the predominant cause of chronic liver disease globally. The standard of care for the treatment of alcoholic hepatitis, corticosteroids, has been shown to provide a therapeutic response in ∼60% of carefully selected patients with a short-term survival benefit. The patients who do not respond to steroids, or are ineligible due to infections or very severe disease, have little options other than liver transplantation. There is, thus, a large unmet need for new therapeutic strategies for this large and sick group of patients. Granulocyte colony stimulating factor (G-CSF) has been shown to favorably modulate the intrahepatic immune milieu and stimulate the regenerative potential of the liver. Initial studies have shown encouraging results with G-CSF in patients with severe alcoholic hepatitis. It has also been found to help steroid nonresponsive patients. There is, however, a need for careful selection of patients, regular dose monitoring and close observation for adverse events of G-CSF. In this review, we analyze the basis of the potential benefits, clinical studies, cautions and challenges in the use of G-CSF in alcoholic hepatitis.

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