Design of Clinical Trials Evaluating Dietary Interventions in Patients With Functional Gastrointestinal Disorders

2013 ◽  
Vol 108 (5) ◽  
pp. 748-758 ◽  
Author(s):  
Chu K Yao ◽  
Peter R Gibson ◽  
Susan J Shepherd
Keyword(s):  
Clinical Trials ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Dietary Interventions

scholarly journals Global Dietary Patterns and Functional Gastrointestinal Disorders

Children ◽  
2020 ◽  
Vol 7 (10) ◽  
pp. 152
Author(s):  
Cara Hannah Axelrod ◽  
Miguel Saps
Keyword(s):  
Clinical Trials ◽  
Treatment Options ◽  
Functional Gastrointestinal Disorders ◽  
The United States ◽  
Gastrointestinal Disorders ◽  
Dietary Interventions ◽  
Nonpharmacological Treatment ◽  
Abdominal Symptoms ◽  
The World ◽  
Consensus View

Functional Gastrointestinal Disorders (FGIDs) are common. In the United States alone, approximately 25 million Americans are estimated to have at least one FGID. Nonpharmacological treatment options include psychological/behavioral approaches, and dietary interventions that can vary across countries. The aim of this review is to evaluate the available evidence for dietary interventions for the treatment of childhood FGIDs amongst various cultures and regions of the world. This review includes clinical trials of dietary therapies for the treatment of FGIDs in children posted on or before 13 July 2020 in PubMed. Overall, the consensus view suggests that the westernization of diets is linked to the development of FGIDs, and diets low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAPs) may reduce abdominal symptoms. However, more work is needed to confirm these findings.

Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children

2015 ◽  
Vol 6 (2) ◽  
pp. 209-217 ◽  
Author(s):  
S. Guandalini ◽  
E. Cernat ◽  
D. Moscoso
Keyword(s):  
Inflammatory Bowel Disease ◽  
Clinical Trials ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Intestinal Microbiota ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Controlled Trials ◽  
Inflammatory Bowel ◽  
Irritable Bowel

Underlying pathophysiological mechanisms of irritable bowel syndrome (IBS), a common disorder characterized by abdominal pain associated to a change in stool consistency or frequency, include low-grade inflammation and intestinal microbiota changes. Few and disappointing data are available for prebiotics. A few controlled trials (RCTs) of probiotics are instead available with favourable effects, although most are limited by suboptimal design and small sample size. A recent report from the Rome foundation group included 32 RCTs of probiotics, most of which showed an overall modest improvement in symptoms, with the patients most benefitting from probiotics being those with predominant diarrhoea and those having a post-infectious IBS. A review focusing only on children with functional gastrointestinal disorders concluded that probiotics are more effective than placebo in the treatment of patients with abdominal pain-related functional gastrointestinal disorders, although no effect on constipation was evident. The role for probiotics in inflammatory bowel disease (IBD) appears logical: the endogenous intestinal microbiota plays a central role in their development, and various probiotics have been found effective in animal models of IBD. However, research in humans has been overall quite limited, and it would seem that after a phase of intense research in the first decade of this century, the pace has slowed down, with fewer clinical trials been published in the past 2-3 years. To summarize current evidence: no probiotic has proven successful in Crohn's disease. In ulcerative colitis, on the other hand, data are more promising, and a very recent meta-analysis, that included 23 randomized controlled trials, concluded that there is evidence of efficacy for the probiotic mixture VSL#3 in helping inducing and maintaining remission, as well as in maintaining remission in patients with pouchitis. It is fair to state that for both IBD and IBS, more well-designed, rigorous, randomized clinical trials must be performed.

scholarly journals Persistent delusions of modern gastroenterology

2017 ◽  
Vol 35 (1) ◽  
pp. 46-54
Author(s):  
Y. S. Tsimmerman
Keyword(s):  
Gastric Cancer ◽  
Clinical Trials ◽  
Helicobacter Pylori ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Ethical Aspects ◽  
Ulcer Disease ◽  
Common Concept ◽  
The Common

The author shares his thoughts about exaggerating the role of infection with Helicobacter pylori in etiology and pathogenesis of chronic gastritis, peptic ulcer disease, gastric cancer. Arguments against the common concept of functional gastrointestinal disorders, formulation of syndromic rather than nosological diagnosis are represented. Particular attention is paid to the moral and ethical aspects of the use of placebo in clinical trials. The shortcomings and errors of the terms that are used in modern gastroenterology are analyzed in detail.

scholarly journals Definition of a responder in clinical trials for functional gastrointestinal disorders: report on a symposium

Gut ◽  
1999 ◽  
Vol 45 (Supplement 2) ◽  
pp. ii78-ii79 ◽  
Author(s):  
W E Whitehead ◽  
E Corazziari ◽  
R Prizont ◽  
J R Senior ◽  
W G Thompson ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Definition Of

scholarly journals Ultrasonic System for Diagnosis of Functional Gastrointestinal Disorders: Development, Verification and Clinical Trials

2007 ◽  
Author(s):  
Q. J. Lee ◽  
W. P. Park ◽  
D. Lim ◽  
D. G. Woo ◽  
C. Y. Ko ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Gastrointestinal Tract ◽  
Research Group ◽  
Functional Gastrointestinal Disorders ◽  
Diagnostic Methods ◽  
Healthy People ◽  
Gastrointestinal Disorders ◽  
Ultrasonic Technique ◽  
Functional Disorders

The number of people who are suffering from Functional gastrointestinal disorders is increasing. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes [1, 2]. Recently our research group identified that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders is more rigid than healthy people. we noticed it with palpating the abdominal regions overlaying the gastrointestinal tract. Therefore we developed a system to detect the rigid organs with ultrasonic technique, which can quantify the characteristic above related to the rigidity of the gastrointestinal tract well.

Families' Perceived Acceptability of Anxiety-Focused CBT for Functional Gastrointestinal Disorders

2012 ◽  
Author(s):  
Erica D. Sood ◽  
Jennifer Shroff Pendley ◽  
Alicia O. Fisher ◽  
Prateek Wali ◽  
Fernando Del Rosario
Keyword(s):  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders
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