Novel Blood Biomarkers of Pancreatic Cancer–Associated Diabetes Mellitus Identified by Peripheral Blood–Based Gene Expression Profiles

2010 ◽  
Vol 105 (7) ◽  
pp. 1661-1669 ◽  
Author(s):  
Hai Huang ◽  
Xin Dong ◽  
Mu Xing Kang ◽  
Bin Xu ◽  
Ying Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Pancreatic Cancer ◽  
Peripheral Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Blood Biomarkers

scholarly journals Exploring the Mechanism of Skeletal Muscle in a Tacrolimus-Induced Posttransplantation Diabetes Mellitus Model on Gene Expression Profiles

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Chenlei Zheng ◽  
Cheng Wang ◽  
Tan Zhang ◽  
Ding Li ◽  
Xiao-feng Ni ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Skeletal Muscle ◽  
Muscle Development ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Enrichment Analysis ◽  
Quadriceps Muscle ◽  
Control Group ◽  
Bioinformatics Analyses

Objective. Posttransplantation diabetes mellitus (PTDM) is a known complication of transplantation that affects the prognosis. Tacrolimus (Tac or FK506) is a widely used immunosuppressant that has been reported to be a risk factor for PTDM and to further induce complications in heart and skeletal muscles, but the mechanism is still largely unknown. In our preliminary experiments, we found that after Tac treatment, blood glucose increased, and the weight of skeletal muscle declined. Here, we hypothesize that tacrolimus can induce PTDM and influence the atrophy of skeletal muscle. Methods. We designed preliminary experiments to establish a tacrolimus-induced PTDM model. Gene expression profiles in quadriceps muscle from this rat model were characterized by oligonucleotide microarrays. Then, differences in gene expression profiles in muscle from PTDM rats that received tacrolimus and control subjects were analyzed by using GeneSpring GX 11.0 software (Agilent). Functional annotation and enrichment analysis of differentially expressed genes (DEGs) helped us identify clues for the side effects of tacrolimus. Results. Our experiments found that the quadriceps in tacrolimus-induced PTDM group were smaller than those in the control group. The study identified 275 DEGs that may be responsible for insulin resistance and the progression of PTDM, including 86 upregulated genes and 199 downregulated genes. GO and KEGG functional analysis of the DEGs showed a significant correlation between PTDM and muscle development. PPI network analysis screened eight hub genes and found that they were related to troponin and tropomyosin. Conclusions. This study explored the molecular mechanism of muscle atrophy in a tacrolimus-induced PTDM model by bioinformatics analyses. We identified 275 DEGs and identified significant biomarkers for predicting the development and progression of tacrolimus-induced PTDM.

Comparison of gene expression profiles of T cells in porcine colostrum and peripheral blood

2016 ◽  
Vol 77 (9) ◽  
pp. 961-968 ◽  
Author(s):  
Shohei Ogawa ◽  
Mie Okutani ◽  
Takamitsu Tsukahara ◽  
Nobuo Nakanishi ◽  
Yoshihiro Kato ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Peripheral Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles

scholarly journals Gene expression profiles of pancreatic cancer and stromal desmoplasia

Oncogene ◽  
2001 ◽  
Vol 20 (50) ◽  
pp. 7437-7446 ◽  
Author(s):  
Tatjana Crnogorac-Jurcevic ◽  
Evangelis Efthimiou ◽  
Paola Capelli ◽  
Ekaterina Blaveri ◽  
Antonella Baron ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles
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