Neorectal Irritability After Short-Term Preoperative Radiotherapy and Surgical Resection for Rectal Cancer

2008 ◽  
Vol 104 (1) ◽  
pp. 133-141 ◽  
Author(s):  
Roel Bakx ◽  
Annemiek Doeksen ◽  
J Frederik M Slors ◽  
Willem A Bemelman ◽  
J Jan B van Lanschot ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Surgical Resection ◽  
Preoperative Radiotherapy ◽  
Short Term

scholarly journals No Downstaging After Short-Term Preoperative Radiotherapy in Rectal Cancer Patients

2001 ◽  
Vol 19 (7) ◽  
pp. 1976-1984 ◽  
Author(s):  
C.A.M. Marijnen ◽  
I.D. Nagtegaal ◽  
E. Klein Kranenbarg ◽  
J. Hermans ◽  
C.J.H. van de Velde ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Tumor Size ◽  
Preoperative Radiotherapy ◽  
Multicenter Trial ◽  
Short Term ◽  
Size Number ◽  
Tumor Node Metastasis Stage ◽  
Poorly Differentiated

PURPOSE: In retrospective studies, total mesorectal excision (TME) surgery has been demonstrated to result in a reduction in the number of local recurrences of rectal cancer. Reports on improved local control after preoperative, hypofractionated radiotherapy have led to the introduction of a randomized multicenter trial to evaluate the effect of TME surgery with and without preoperative radiotherapy. Treatment with preoperative radiotherapy might have an effect on the pathologic characteristics that determine staging of rectal cancer. We investigated the occurrence of downstaging in rectal cancer patients treated with and without preoperative radiotherapy. PATIENTS AND METHODS: We analyzed the differences in tumor size, number of examined lymph nodes, tumor-node-metastasis stage, and histopathologic features in 1,321 patients entered onto a randomized trial. The trial compared preoperative radiotherapy (5 × 5 Gy) followed by TME surgery with TME surgery alone. Patients who had an interval of more than 10 days between the start of radiotherapy and surgery were excluded from analysis. RESULTS: Differences were observed in tumor size (P < .001) and total number of examined lymph nodes (P < .001). No difference in tumor or node classification was detected. The irradiated group demonstrated more poorly differentiated tumors as well as more mucinous tumors. CONCLUSION: In rectal cancer patients, short-term, preoperative radiotherapy with 5 × 5 Gy does not lead to downstaging if the interval between the start of radiotherapy and surgery does not exceed 10 days.

Short-term preoperative radiotherapy interferes with the determination of pathological parameters in rectal cancer

2002 ◽  
Vol 197 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Iris D. Nagtegaal ◽  
Corrie A. M. Marijnen ◽  
Elma Klein Kranenbarg ◽  
Adri Mulder-Stapel ◽  
Jo Hermans ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Preoperative Radiotherapy ◽  
Short Term

Acute Radiation Colitis in Patients Treated With Short-Term Preoperative Radiotherapy for Rectal Cancer

2002 ◽  
Vol 26 (4) ◽  
pp. 498-504 ◽  
Author(s):  
Nicolas Leupin ◽  
Jürgen Curschmann ◽  
Helmut Kranzbühler ◽  
Christoph A. Maurer ◽  
Jean A. Laissue ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Preoperative Radiotherapy ◽  
Acute Radiation ◽  
Short Term ◽  
Radiation Colitis

Short-term preoperative radiotherapy for resectable rectal cancer (RRC)

2013 ◽  
Vol 18 ◽  
pp. S71
Author(s):  
J. Ciria Santos ◽  
S. Cafiero Ballesteros ◽  
I. Diaz de Cerio Martinez ◽  
G. Rodriguez Moreno ◽  
E. Guimon Olaizola ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Preoperative Radiotherapy ◽  
Short Term ◽  
Resectable Rectal Cancer

Impact of Short-Term Preoperative Radiotherapy on Health-Related Quality of Life and Sexual Functioning in Primary Rectal Cancer: Report of a Multicenter Randomized Trial

2005 ◽  
Vol 23 (9) ◽  
pp. 1847-1858 ◽  
Author(s):  
Corrie A.M. Marijnen ◽  
Cornelis J.H. van de Velde ◽  
Hein Putter ◽  
Mandy van den Brink ◽  
Cornelis P. Maas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Sexual Functioning ◽  
Preoperative Radiotherapy ◽  
Health Related Quality ◽  
Short Term ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Background Few prospective studies have been performed about the impact of preoperative radiotherapy (PRT) or total mesorectal excision (TME) on health-related quality of life (HRQL) and sexual functioning in patients with resectable rectal cancer. This report describes the HRQL and sexual functioning of 990 patients who underwent TME and were randomly assigned to short-term PRT (5 × 5 Gy). Patients and Methods The Rotterdam Symptom Check List supplemented with additional items was used with questionnaires before treatment and at 3, 6, 12, 18, and 24 months after surgery. Patients without a recurrence the first 2 years were analyzed (n = 990). Results Few differences were found in HRQL between patients treated with or without PRT. Daily activities were significantly less for PRT patients 3 months postoperatively. Irradiated patients recovered slower from defecation problems than TME-only patients (P = .006). PRT had a negative effect on sexual functioning in males (P = .004) and females (P < .001). Irradiated males had more ejaculation disorders (P = .002), and erectile functioning deteriorated over time (P < .001). PRT had similar effects in patients who underwent a low anterior resection (LAR) versus an abdominoperineal resection (APR). Patients with an APR scored better on the physical (P = .004) and psychologic dimension (P = .007) than LAR patients, but worse on voiding (P = .0007). Conclusion Short-term PRT leads to more sexual dysfunction, slower recovery of bowel function, and impaired daily activity postoperatively. However, this does not seriously affect HRQL. The comparison between LAR and APR patients demonstrates that the existence of a permanent stoma is not the only determinant of HRQL.

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