Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

10.1038/89901 ◽  
2001 ◽  
Vol 7 (7) ◽  
pp. 781-787 ◽  
Author(s):  
David Kirn ◽  
Robert L. Martuza ◽  
James Zwiebel
1990 ◽  
Vol 6 (5) ◽  
pp. 217-233 ◽  
Author(s):  
L. D. Grant ◽  
A. M. Jarabek

This paper has been reviewed by the Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. The U.S. EPA has increasingly relied upon quantitative health risk assessments as the basis for management decisions about public health protection. Full utilization of risk assessment in management applications, however, is limited by uncertainties in the resultant accuracy of the risk estimates. This paper will discuss a research strategy to address the uncertainties in the risk assessment process and describe parallel issues to address in the risk management area. An attendant need for effective communication of complex scientific concepts is also identified.


2008 ◽  
Vol 14 ◽  
pp. 159-164 ◽  
Author(s):  
I. Alcántara-Ayala

Abstract. Landslides disasters in Mexico caused more than 3500 deaths between 1935 and 2006. Such disasters have been mainly associated to intense precipitation events derived from hurricanes, tropical storms and their interactions with cold fronts, although earthquake triggered landslides have also occurred to a lesser extent. The impact of landsliding in Mexico is basically determined by the geomorphic features of mountain ranges and dissected plateaus inhabited by vulnerable communities. The present contribution provides a comprehensive temporal assessment of historical landslide disasters in Mexico. Moreover, it aims at exploring the future directions of risk management and disaster prevention, in order to reduce the impact of landslides on populations as a result of climatic change, urban sprawl, land use change and social vulnerability.


This chapter outlines the future directions for the Risk Management research. Eminent Risk Mangement scholars and practitioners are referenced considering the future direction for Risk Management in general across industries. Also, references to the future directions for specific industries, disciplines and corporate businesses are provided including: 1) Financial Risk Management; 2) Information Systems Security; 3) Energy Sector; 4) Project Management; 5) Construction Industry; 6) Supply Chain; 7) Agriculture; and 8) Six Sigma.


Author(s):  
Jill D. Stinson ◽  
Judith V. Becker

Chapter 16 describes the clinical case of an adult male who meets diagnostic criteria for pedophilia and who has acted on his pedophilic interests on several known occasions. It addresses important historical and clinical characteristics of the case, as well as treatment efforts and indicators of risk. It also discusses the application of empirically supported practices and clinical science to the assessment, treatment, and risk management of this client, highlighting what is known from the scientific literature, and future directions that will aid in the clinical care of individuals with pedophilic diagnoses.


2020 ◽  
Vol 38 (1) ◽  
pp. 78-94 ◽  
Author(s):  
Priscila Ferreira de Araújo Lima ◽  
Maria Crema ◽  
Chiara Verbano

2021 ◽  
Vol 4 (1) ◽  
pp. 43-48
Author(s):  
Luma Mirely de Souza Brandão ◽  
Milson dos Santos Barbosa ◽  
Isabela Nascimento Souza ◽  
Lays Carvalho de Almeida ◽  
Danyelle Andrade Mota ◽  
...  

An option to change partially or completely conventional chemical methods is a biotechnological process. It enables the development of environmentally friendly and innovative means. The safety of this process has not been fully examined, thus, the lack of awareness about risk management is a great concern. This work aims to elucidate the importance of recognizing, assessing, and controlling potential risks, and developing appropriate risk management to develop bioprocesses safely. For this purpose, qualitative research was carried out through scientific studies and current legislation. Safe development of biotechnological procedures allows for occupational safety throughout the processes. It was observed that control measures should be adopted to obtain a safe work environment for everyone. These measures can be carried out through anticipation, recognition, assessment, and control of existing risks or that may exist in the process. Also, it was found that the involvement of all adequate risk management is fundamental. Therefore, biotechnological processes must be developed safely for workers, the environment, and society.  


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