Identification of the gene that, when mutated, causes the human obesity syndrome BBS4

10.1038/88925 ◽  
2001 ◽  
Vol 28 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Kirk Mykytyn ◽  
Terry Braun ◽  
Rivka Carmi ◽  
Neena B. Haider ◽  
Charles C. Searby ◽  
...  
Keyword(s):  
Human Obesity ◽  
Obesity Syndrome

Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15

1995 ◽  
Vol 4 (1) ◽  
pp. 9-13 ◽  
Author(s):  
R. Carmi ◽  
T. Rokhlina ◽  
A. E. Kwitek-Black ◽  
K. Elbedour ◽  
D. Nishimura ◽  
...  
Keyword(s):  
Chromosome 15 ◽  
Human Obesity ◽  
Dna Pooling ◽  
Pooling Strategy ◽  
Obesity Syndrome

Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome

10.1038/ng935 ◽  
2002 ◽  
Vol 31 (4) ◽  
pp. 435-438 ◽  
Author(s):  
Kirk Mykytyn ◽  
Darryl Y. Nishimura ◽  
Charles C. Searby ◽  
Mythreyi Shastri ◽  
Hsan-jan Yen ◽  
...  
Keyword(s):  
Human Obesity ◽  
Bardet Biedl Syndrome ◽  
Obesity Syndrome

scholarly journals Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome

2010 ◽  
Vol 206 (3) ◽  
pp. 287-296 ◽  
Author(s):  
Andreas Nygaard Madsen ◽  
Gitte Hansen ◽  
Sarah Juel Paulsen ◽  
Kirsten Lykkegaard ◽  
Mads Tang-Christensen ◽  
...  
Keyword(s):  
Animal Model ◽  
Body Weight ◽  
Food Intake ◽  
Glucose Tolerance ◽  
Glucose Homeostasis ◽  
Rat Model ◽  
High Energy ◽  
Human Obesity ◽  
Obesity Syndrome

The availability of useful animal models reflecting the human obesity syndrome is crucial in the search for novel compounds for the pharmacological treatment of obesity. In the current study, we have performed an extensive characterization of the obesity syndrome in a polygenetic animal model, namely the selectively bred diet-induced obese (DIO) and diet-resistant (DR) rat strains. We show that they constitute useful models of the human obesity syndrome. DIO and DR rats were fed either a high-energy (HE) or a standard chow (Chow) diet from weaning to 9 months of age. Metabolic characterization including blood biochemistry and glucose homeostasis was examined at 2, 3, 6, and 9 months of age. Furthermore, in 6-month-old HE-fed DIO rats, the anti-obesity effects of liraglutide and sibutramine were examined in a 28-day study. Only HE-fed DIO rats developed visceral obesity, hyperleptinemia, hyperinsulinemia, and dyslipidemia, and showed a worsening of glucose tolerance over time. In line with the hyperlipidemic profile, a severe hepatic fat infiltration was observed in DIO rats at 6 months of age. The effects of liraglutide and sibutramine were tested in 6-month-old DIO rats. Both compounds effectively reduced food intake and body weight in DIO rats. Liraglutide furthermore improved glucose tolerance when compared with sibutramine. Our data highlights the usefulness of a polygenetic animal model for screening of compounds affecting food intake, body weight, and glucose homeostasis. Furthermore, the results underscore the effectiveness of GLP-1 mimetics both as anti-diabetes and anti-obesity agents.

Association between Emotional Regulation (ER) and Prefrontal Noradrenalin Transporter (NAT) Availability in Human Obesity

2020 ◽  
Author(s):  
S Hesse ◽  
A McLeod ◽  
M Rullmann ◽  
GA Becker ◽  
J Luthardt ◽  
...  
Keyword(s):  
Emotional Regulation ◽  
Human Obesity
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