Lysosomal ceroid depletion by drugs: Therapeutic implications for a hereditary neurodegenerative disease of childhood

10.1038/86554 ◽  
2001 ◽  
Vol 7 (4) ◽  
pp. 478-484 ◽  
Author(s):  
Zhongjian Zhang ◽  
Jean DeB. Butler ◽  
Sondra W. Levin ◽  
Krystyna E. Wisniewski ◽  
Susan S. Brooks ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Therapeutic Implications

Aluminum and Neurodegenerative Disease: Therapeutic Implications

1985 ◽  
Vol 6 (5) ◽  
pp. 322-329 ◽  
Author(s):  
D.R. Crapper McLachlan ◽  
T.P.A. Kruck ◽  
M.F.A. VanBerkum
Keyword(s):  
Neurodegenerative Disease ◽  
Therapeutic Implications

Memory Processes, Aging, Cognitive Decline, and Neurodegenerative Diseases

2006 ◽  
Vol 11 (4) ◽  
pp. 304-311 ◽  
Author(s):  
Lars-Göran Nilsson
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Neurodegenerative Disease ◽  
Genetic Markers ◽  
Brain Activity ◽  
Memory Performance ◽  
Modeling And Simulations ◽  
Aging And Health ◽  
Explained Variance ◽  
Different Levels

This paper presents four domains of markers that have been found to predict later cognitive impairment and neurodegenerative disease. These four domains are (1) data patterns of memory performance, (2) cardiovascular factors, (3) genetic markers, and (4) brain activity. The critical features of each domain are illustrated with data from the longitudinal Betula Study on memory, aging, and health ( Nilsson et al., 1997 ; Nilsson et al., 2004 ). Up to now, early signs regarding these domains have been examined one by one and it has been found that they are associated with later cognitive impairment and neurodegenerative disease. However, it was also found that each marker accounts for only a very small part of the total variance, implying that single markers should not be used as predictors for cognitive decline or neurodegenerative disease. It is discussed whether modeling and simulations should be used as tools to combine markers at different levels to increase the amount of explained variance.

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