Müller glia are a potential source of neural regeneration in the postnatal chicken retina

10.1038/85090 ◽  
2001 ◽  
Vol 4 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Andy J. Fischer ◽  
Thomas A. Reh
Keyword(s):  
Neural Regeneration ◽  
Muller Glia ◽  
Müller Glia ◽  
Potential Source ◽  
Chicken Retina

scholarly journals STAT pathway activation limits the Ascl1-mediated chromatin remodeling required for neural regeneration from Müller glia in adult mouse retina

2019 ◽  
Author(s):  
Nikolas L. Jorstad ◽  
Matthew S. Wilken ◽  
Levi Todd ◽  
Paul Nakamura ◽  
Nick Radulovich ◽  
...  
Keyword(s):  
Adult Mouse ◽  
Neural Regeneration ◽  
Mouse Retina ◽  
Binding Motif ◽  
Muller Glia ◽  
Müller Glia ◽  
Rna Seq ◽  
Transgenic Expression ◽  
Pathway Activation ◽  
Stat Pathway

AbstractMüller glia can serve as a source for retinal regeneration in some non-mammalian vertebrates. Recently we found that this process can be induced in mouse Müller glia after injury, by combining transgenic expression of the proneural transcription factor Ascl1 and the HDAC inhibitor TSA. However, new neurons are only generated from a subset of Müller glia in this model, and identifying factors that limit Ascl1-mediated MG reprogramming could potentially make this process more efficient, and potentially useful clinically. One factor that limits neurogenesis in some non-mammalian vertebrates is the STAT pathway activation that occurs in Müller glia in response to injury. In this report, we tested whether injury induced STAT activation hampers the ability of Ascl1 to reprogram Müller glia into retinal neurons. Using a STAT inhibitor, in combination with our previously described reprogramming paradigm, we found a large increase in the ability of Müller glia to generate neurons, similar to those we described previously. Single-cell RNA-seq showed that the progenitor-like cells derived from Ascl1-expressing Müller glia have a higher level of STAT signaling than those that become neurons. Using Ascl1 ChIP-seq and DNase-seq, we found that developmentally inappropriate Ascl1 binding sites (that were unique to the overexpression context) had enrichment for the STAT binding motif. This study provides evidence that STAT pathway activation reduces the efficiency of Ascl1-mediated reprogramming in Müller glia, potentially by directing Ascl1 to inappropriate targets.

scholarly journals STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina

Cell Reports ◽  
2020 ◽  
Vol 30 (7) ◽  
pp. 2195-2208.e5 ◽  
Author(s):  
Nikolas L. Jorstad ◽  
Matthew S. Wilken ◽  
Levi Todd ◽  
Connor Finkbeiner ◽  
Paul Nakamura ◽  
...  
Keyword(s):  
Adult Mouse ◽  
Neural Regeneration ◽  
Mouse Retina ◽  
Muller Glia ◽  
Chromatin Binding ◽  
Müller Glia ◽  
Stat Signaling

scholarly journals Insulin and Fibroblast Growth Factor 2 Activate a Neurogenic Program in Müller Glia of the Chicken Retina

2002 ◽  
Vol 22 (21) ◽  
pp. 9387-9398 ◽  
Author(s):  
Andy J. Fischer ◽  
Christopher Roger McGuire ◽  
Blair Dorian Dierks ◽  
Thomas A. Reh
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Muller Glia ◽  
Müller Glia ◽  
Chicken Retina

scholarly journals Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1957
Author(s):  
Ahmed Salman ◽  
Michelle McClements ◽  
Robert MacLaren
Keyword(s):  
Cell Types ◽  
Neural Progenitors ◽  
Muller Glia ◽  
Müller Glia ◽  
Regeneration Potential ◽  
Regenerative Capacity ◽  
Structural Support ◽  
Potential Source ◽  
Retinal Photoreceptors ◽  
Mammalian Retina

Müller glia, the major glial cell types in the retina, maintain retinal homeostasis and provide structural support to retinal photoreceptors. They also possess regenerative potential that might be used for retinal repair in response to injury or disease. In teleost fish (such as zebrafish), the Müller glia response to injury involves reprogramming events that result in a population of proliferative neural progenitors that can regenerate the injured retina. Recent studies have revealed several important mechanisms for the regenerative capacity of Müller glia in fish, which may shed more light on the mechanisms of Müller glia reprogramming and regeneration in mammals. Mammalian Müller glia can adopt stem cell characteristics, and in response to special conditions, be persuaded to proliferate and regenerate, although their native regeneration potential is limited. In this review, we consider the work to date revealing the regenerative potential of the mammalian Müller glia and discuss whether they are a potential source for cell regeneration therapy in humans.

Müller Glia-Mediated Retinal Regeneration

2021 ◽  
Author(s):  
Hui Gao ◽  
Luodan A ◽  
Xiaona Huang ◽  
Xi Chen ◽  
Haiwei Xu
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Retinal Regeneration

Müller glia–myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish

Glia ◽  
2021 ◽  
Author(s):  
Annelies Van Dyck ◽  
Ilse Bollaerts ◽  
An Beckers ◽  
Sophie Vanhunsel ◽  
Nynke Glorian ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Myeloid Cell ◽  
Muller Glia ◽  
Müller Glia ◽  
Adult Zebrafish ◽  
Optic Nerve Regeneration ◽  
Cell Crosstalk
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