Immune suppression and skin cancer development: regulation by NKT cells

10.1038/82782 ◽  
2000 ◽  
Vol 1 (6) ◽  
pp. 521-525 ◽  
Author(s):  
Angus M. Moodycliffe ◽  
Dat Nghiem ◽  
Gavin Clydesdale ◽  
Stephen E. Ullrich
Keyword(s):  
Skin Cancer ◽  
Immune Suppression ◽  
Nkt Cells ◽  
Cancer Development ◽  
Development Regulation

scholarly journals 061 Absence of Adrb2 minimally affects UV-induced immunosuppression and skin cancer development

2021 ◽  
Vol 141 (5) ◽  
pp. S11
Author(s):  
A. Shahid ◽  
M. Huang ◽  
S. Yeung ◽  
C. Parsa ◽  
R. Orlando ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Development

scholarly journals Platelet-activating Factor, a Molecular Sensor for Cellular Damage, Activates Systemic Immune Suppression

2002 ◽  
Vol 195 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Jeffrey P. Walterscheid ◽  
Stephen E. Ullrich ◽  
Dat X. Nghiem
Keyword(s):  
Skin Cancer ◽  
Uv Radiation ◽  
Immune Suppression ◽  
Critical Role ◽  
Platelet Activating Factor ◽  
Cellular Damage ◽  
Uv Exposure ◽  
Delayed Type Hypersensitivity ◽  
Lipid Mediator ◽  
Paf Receptor

Ultraviolet (UV) radiation plays a critical role in the induction of nonmelanoma skin cancer. UV radiation is also immune suppressive, and the immune suppression induced by UV irradiation has been identified as a major risk factor for skin cancer induction. Previously, we showed that UV exposure activates a cytokine cascade involving prostaglandin (PG)E2, interleukin (IL)-4, and IL-10 that induces immune suppression. However, the earliest molecular events that occur immediately after UV exposure, especially those upstream of PGE2, are not well defined. UV-irradiated keratinocytes secrete the inflammatory phospholipid mediator, platelet-activating factor (PAF). Because PAF upregulates the production of immunomodulatory compounds, including PGE2, we tested the hypothesis that UV-induced PAF activates cytokine production and initiates UV-induced immune suppression. Both UV and PAF activated cyclooxygenase (COX)-2 and IL-10 reporter gene construct transcription. PAF mimicked the effects of UV in vivo and suppressed delayed-type hypersensitivity (DTH). Furthermore, immune suppression was blocked when UV-irradiated mice were injected with PAF receptor antagonists. In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression.

Patients with solar keratosis, particularly of the trunk or lower extremities, are at high risk for skin cancer development

2005 ◽  
Vol 30 (6) ◽  
pp. 717-718 ◽  
Author(s):  
G. F. Graham ◽  
F. Camacho ◽  
I. Roseborough ◽  
S. Taylor ◽  
B. Gratton ◽  
...  
Keyword(s):  
High Risk ◽  
Skin Cancer ◽  
Lower Extremities ◽  
Cancer Development ◽  
Solar Keratosis

Effect of hair removal on solar UV transmission into skin and implications for melanoma skin cancer development

2020 ◽  
Vol 37 (5) ◽  
pp. 807
Author(s):  
Xiyong Huang ◽  
Michael D. Protheroe ◽  
Ahmed M. Al-Jumaily ◽  
Sharad P. Paul ◽  
Andrew N. Chalmers
Keyword(s):  
Skin Cancer ◽  
Cancer Development ◽  
Hair Removal ◽  
Solar Uv ◽  
Melanoma Skin

Professional risk for skin cancer development in male mountain guides - a cross-sectional study

2009 ◽  
Vol 24 (7) ◽  
pp. 797-804 ◽  
Author(s):  
V Lichte ◽  
B Dennenmoser ◽  
K Dietz ◽  
H-M Häfner ◽  
B Schlagenhauff ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cross Sectional Study ◽  
Cancer Development ◽  
Sectional Study ◽  
Cross Sectional
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