Functional genomics of Neisseria meningitidis pathogenesis

10.1038/81380 ◽  
2000 ◽  
Vol 6 (11) ◽  
pp. 1269-1273 ◽  
Author(s):  
Yao-Hui Sun ◽  
Sharmila Bakshi ◽  
Ronald Chalmers ◽  
Christoph M. Tang
Keyword(s):  
Functional Genomics ◽  
Neisseria Meningitidis

Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens

2004 ◽  
Vol 113 (1-3) ◽  
pp. 15-32 ◽  
Author(s):  
Davide Serruto ◽  
Jeannette Adu-Bobie ◽  
Barbara Capecchi ◽  
Rino Rappuoli ◽  
Mariagrazia Pizza ◽  
...  
Keyword(s):  
Functional Genomics ◽  
Neisseria Meningitidis ◽  
Bacterial Pathogens

scholarly journals Unraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1228 ◽  
Author(s):  
Marco Soriani
Keyword(s):  
Functional Genomics ◽  
Neisseria Meningitidis ◽  
Cell Biology ◽  
Virulence Genes ◽  
Experimental Models ◽  
Commensal Bacterium ◽  
Pathogenic Potential ◽  
Acute Meningitis ◽  
Tissue Models

Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under “privileged” conditions, it adopts a “devious” lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and acute meningitis. Indeed, despite the lack of a classic repertoire of virulence genes in N. meningitidis separating commensal from invasive strains, molecular epidemiology and functional genomics studies suggest that carriage and invasive strains belong to genetically distinct populations characterized by an exclusive pathogenic potential. In the last few years, “omics” technologies have helped scientists to unwrap the framework drawn by N. meningitidis during different stages of colonization and disease. However, this scenario is still incomplete and would benefit from the implementation of physiological tissue models for the reproduction of mucosal and systemic interactions in vitro. These emerging technologies supported by recent advances in the world of stem cell biology hold the promise for a further understanding of N. meningitidis pathogenesis.

Epidemiología de la meningitis producida por Haemophilus influenzae tipo b, Neisseria meningitidis y Streptococcus pneumoniae en niños de la Comunidad Valenciana, España

1998 ◽  
Vol 26 (149) ◽  
pp. 34 ◽  
Author(s):  
Mª Amparo Morant Gimeno ◽  
J. Díez Domingo ◽  
C. Gimeno ◽  
N. de la Muela ◽  
I. Pereiró ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Neisseria Meningitidis
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