Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

10.1038/79758 ◽  
2000 ◽  
Vol 1 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Anja Langenkamp ◽  
Mara Messi ◽  
Antonio Lanzavecchia ◽  
Federica Sallusto
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Kinetics Of

scholarly journals Human Lymphocyte Activation Gene-3 Molecules Expressed by Activated T Cells Deliver Costimulation Signal for Dendritic Cell Activation

2008 ◽  
Vol 180 (6) ◽  
pp. 3782-3788 ◽  
Author(s):  
Chiara Casati ◽  
Chiara Camisaschi ◽  
Luisa Novellino ◽  
Arabella Mazzocchi ◽  
Frédéric Triebel ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Human Lymphocyte ◽  
Cell Activation ◽  
Lymphocyte Activation ◽  
Dendritic Cell Activation ◽  
Activated T Cells ◽  
Lymphocyte Activation Gene

scholarly journals CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches

Immunity ◽  
2006 ◽  
Vol 24 (5) ◽  
pp. 623-632 ◽  
Author(s):  
Rosa Maria Salazar-Gonzalez ◽  
Jan H. Niess ◽  
David J. Zammit ◽  
Rajesh Ravindran ◽  
Aparna Srinivasan ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Dendritic Cell Activation

scholarly journals Anti–IL6-receptor-alpha (tocilizumab) does not inhibit human monocyte-derived dendritic cell maturation or alloreactive T-cell responses

Blood ◽  
2011 ◽  
Vol 118 (19) ◽  
pp. 5340-5343 ◽  
Author(s):  
Brian C. Betts ◽  
Erin T. St Angelo ◽  
Michael Kennedy ◽  
James W. Young
Keyword(s):  
Cell Proliferation ◽  
T Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Human Monocyte ◽  
T Cell Proliferation ◽  
Dendritic Cell Activation ◽  
Alloreactive T Cell

Abstract Significant comorbidites and lethality complicate GVHD and its treatment. Targeting the cytokine milieu may improve GVHD control; and IL6 is an attractive candidate, given its role in dendritic cell activation and T-cell differentiation. Tocilizumab is a humanized mAb to IL6-receptor-α (IL6R-α), which is Food and Drug Administration–approved for treatment of rheumatoid arthritis. Mouse transplant models have demonstrated that IL6 blockade also improves GVHD scores and survival. Definitive immunologic effects of IL6 inhibition have not emerged given inconsistent alterations in regulatory T cells (Tregs) and suppression of T-cell proliferation. Despite on-target suppression of IL6R-α signaling in human monocyte-derived dendritic cells (moDCs) and T cells, our data show no effect on moDC maturation/activation, alloreactive T-cell proliferation, Treg expansion, or allogeneic Th1/Th17 responses in vitro. These findings merit attention in any clinical trials of tocilizumab for GVHD prevention or treatment and provide a rationale for evaluating more specific inhibitors of downstream JAK2/STAT3 signaling as well.

scholarly journals Organic components of airborne dust influence the magnitude and kinetics of dendritic cell activation

2018 ◽  
Vol 50 ◽  
pp. 391-398 ◽  
Author(s):  
Magali Boucher ◽  
Pascale Blais Lecours ◽  
Valérie Létourneau ◽  
Marc Veillette ◽  
Caroline Duchaine ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Airborne Dust ◽  
Organic Components ◽  
Kinetics Of

scholarly journals Salmonella typhimuriumCoordinately Regulates FliC Location and Reduces Dendritic Cell Activation and Antigen Presentation to CD4+T cells

2006 ◽  
Vol 177 (6) ◽  
pp. 3983-3993 ◽  
Author(s):  
Robert C. Alaniz ◽  
Lisa A. Cummings ◽  
Molly A. Bergman ◽  
Sara L. Rassoulian-Barrett ◽  
Brad T. Cookson
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Dendritic Cell Activation

scholarly journals Enhancement of dendritic cell activation via CD40 ligand-expressing γδ T cells is responsible for protective immunity toPlasmodiumparasites

2012 ◽  
Vol 109 (30) ◽  
pp. 12129-12134 ◽  
Author(s):  
Shin-Ichi Inoue ◽  
Mamoru Niikura ◽  
Satoru Takeo ◽  
Shoichiro Mineo ◽  
Yasushi Kawakami ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Protective Immunity ◽  
Cell Activation ◽  
Γδ T Cells ◽  
Cd40 Ligand ◽  
Dendritic Cell Activation
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