G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors

10.1038/7243 ◽  
1999 ◽  
Vol 2 (4) ◽  
pp. 331-338 ◽  
Author(s):  
W-Y. Lu ◽  
Z-G. Xiong ◽  
S. Lei ◽  
B. A. Orser ◽  
E. Dudek ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nmda Receptors ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Kinase C ◽  
G Protein Coupled

Multiple Signaling Pathways for Platelet-Activating Factor Receptor

Physiology ◽  
1992 ◽  
Vol 7 (2) ◽  
pp. 72-75
Author(s):  
SD Shukla
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathways ◽  
G Protein ◽  
Platelet Activating Factor ◽  
G Protein Coupled Receptors ◽  
Kinase C ◽  
Paf Receptor ◽  
Multiple Signaling ◽  
G Protein Coupled

Platelet-activating factor (PAF) receptor is coupled to multiple signaling pathways, including phospholipid turnover via phospholipases C, D, A2;Ca2+ mobilization;and activation of protein kinase C and tyrosine kinase. The cloned receptor shows homology to G protein-coupled receptors. These developments highlight receptor functions of this novel phospholipid agonist.

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