scholarly journals Human clone update

10.1038/6097 ◽  
1999 ◽  
Vol 17 (2) ◽  
pp. 119-119
Author(s):  
Asako Saegusa
Keyword(s):  
Human Clone

Human Clone Success in Debate

Science News ◽  
1979 ◽  
Vol 115 (9) ◽  
pp. 131
Author(s):  
Landrum B. Shettles ◽  
Pierre Soupart
Keyword(s):  
Human Clone

‘We’re not programmed, we’re people’: Figuring the caring computer

2012 ◽  
Vol 13 (2) ◽  
pp. 197-211 ◽  
Author(s):  
Robin Stoate
Keyword(s):  
Science Fiction ◽  
Human Subjects ◽  
Caring Relationships ◽  
Companion Species ◽  
Feminist Theories ◽  
Human Clone ◽  
The Relationship ◽  
Affective Impact

This article intervenes in feminist theories concerning the politics of care, reading this contested notion through its representation in an ‘artificial’ relationship between a human clone and a computer in the science fiction film Moon (dir. Duncan Jones, 2009). Drawing on Joan Tronto’s work (1993), I delineate a conventional, vernacular conception of care, which puts in place problematic, prescriptive roles in caring relationships. Then, reading Moon through Donna Haraway’s theorisation of companion species (2008) and what she terms the ‘touching’ of material histories and contingencies, I show how these hierarchies may be unravelled. This figure of the caring computer represents a capacity for affective impact upon human subjects that is not normally ascribed to ‘emotionless’ technological subjects. It animates a disruption of the linear, instrumental relationships of power between humans and technologies by showing the ways in which ongoing processes of co-constitution are responsible for bringing each participant in the relationship into being. Care here is a manner of activating and making conspicuous those processes and can unravel, rather than prescribe, the roles which respective participants in such relationships are assigned.

Zap-70 on Bone Marrow Biopsy Is a Good Prognostic Indicator in B-CLL.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4774-4774
Author(s):  
Giorgio Lambertenghi Deliliers ◽  
Claudia Vener ◽  
Umberto Gianelli ◽  
Silvano Bosari ◽  
Federica Savi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Flow Cytometry ◽  
Statistical Difference ◽  
Prognostic Significance ◽  
Prognostic Indicator ◽  
Lymphocytic Leukemia ◽  
Bone Marrow Biopsies ◽  
Human Clone ◽  
C 30 ◽  
One Year

Abstract Bone marrow biopsies (BMB) taken at the time of diagnosis of 108 patients with chronic lymphocytic leukemia (B-CLL) (median age: 62 years, range: 36–81; M/F ratio: 2/1) were collected between 1985 and 2004, and tested immunohistochemically for the expression of ZAP-70 (zeta-associated protein 70), “Anti-ZAP-70 (human), clone 2F3.2 (mouse monoclonal IgG2a)”. There were degrees of ZAP-70 expression: “negative (a)” (58 patients), “weak (b)” (20 patients) and “intense (c)” (30 patients)” in comparison with natural killer (NK) and T-cell ZAP-70 expression (BMB positive when 20% of B-CLL cells express ZAP-70). The cases were analysed separately by three different experts. In terms of BMB morphology, proliferative centres were 36% in (a) 35% in (b) and 47% in (c); a diffuse pattern: 8.6% in (a), 10% in (b) and 13% in (c); a nodular pattern: 66% in (a), 55% in (b) and 37% in (c): (a) vs (b+c) (p=0.024), (a+b) vs (c) (p=0.014). The different degrees of ZAP-70 expression correlated with two groups of patients according to the Rai and Binet criteria: “0-I-II, A” and “II-III-IV, B, C”. Cases (a) correspond more frequently to the first, and (b+c) to the second (p=0.013); moreover, cases (a+b) correspond more frequently to the first group, and (c) to the second (p=0.0026). A lymphocyte doubling time (LDT) of less than six months and less than one year was most frequent in (c) (p=0.00044) (p=0.0065). An LDT of less than one year was more frequent in (b+c) vs (a) (p=0,01). Patients receiving no therapy were more frequent in (a) or (a+b) (p=0.00011) (p=0.00045). Patients receiving no therapy or only one line of treatment were more frequent in (a) or (a+b) (p=3.2x10–5) (p=0.0073). Cytogenetic abnormalities were more frequent in (a) or (a+b) (p=0.017) (p=0.022), and complex caryotypes more frequent in (a+b), (p=0.016). The incidence of death was lower in (a+b) than (c) (8% vs 27%) (p=0.041). Mann-Whitney analysis showed a statistical difference between (a+b) and (c) for the following variables at diagnosis: PLT (p=0.02); WBC (p=0.05); Ly (p=0.055); LDH (p=0.015); B2m (p=0.0005); splenomegaly (p=0.03); and a statistical difference between (a) vs (b+c) for the following variables at diagnosis: PLT (p=0.044); LDH (p=0.006); B2m (p=0.003); percentage of bone marrow infiltrate (p=0.055); CD 38 flow-cytometry (p=0.0009). Kruskall-Wallis analysis of (a) vs (b) vs (c) showed a statistical difference for the following variables at diagnosis: LDH (p=0.01); B2m (p=0.0017); CD 38 flow-cytometry (p=0.0051). These data confirm the prognostic significance of ZAP-70 expression in patients with B-CLL, and its good correlation with clinical and cytogenetic parameters and the Rai-Binet classification.

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